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Heterogeneity of Stem Cells: A Brief Overview

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Stem Cell Heterogeneity

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1516))

Abstract

Stem cells possess the extraordinary capacity of self-renewal and differentiation to various cell types, thus to form original tissues and organs. Stem cell heterogeneity including genetic and nongenetic mechanisms refers to biological differences amongst normal and stem cells originated within the same tissue. Cell differentiation hierarchy and stochasticity in gene expression and signaling pathways may result in phenotypic differences of stem cells. The maintenance of stemness and activation of differentiation potential are fundamentally orchestrated by microenvironmental stem cell niche-related cellular and humoral signals.

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  1. 2nd Department of Medicine, Immunology Division, Semmelweis University, Szentkirályi u. 46., Budapest, 1088, Hungary

    Györgyi Műzes & Ferenc Sipos

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  1. Györgyi Műzes
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  2. Ferenc Sipos
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Correspondence to Györgyi Műzes .

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  1. Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

    Kursad Turksen

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Műzes, G., Sipos, F. (2016). Heterogeneity of Stem Cells: A Brief Overview. In: Turksen, K. (eds) Stem Cell Heterogeneity. Methods in Molecular Biology, vol 1516. Humana Press, New York, NY. https://doi.org/10.1007/7651_2016_345

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  • DOI: https://doi.org/10.1007/7651_2016_345

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  • Print ISBN: 978-1-4939-6549-6

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