1. Pharmacokinetic study of low- versus high-dose medroxyprogesterone acetate (MPA) in women

   • Tomoko Ohtsu
   • Hirofumi Fujii
   • Yasutsuna Sasaki

   ORIGINAL ARTICLE Pages: 1 - 8

2. Reversal of multidrug resistance by a liposome-MDR1 ribozyme complex

   • Yoshihiro Masuda
   • Hiroyuki Kobayashi
   • Takao Ohnuma

   ORIGINAL ARTICLE Pages: 9 - 16

3. Toxicity of cytostatic drugs to normal bone marrow cells in vitro

   • Britt Sundman-Engberg
   • Ulf Tidefelt
   • Christer Paul

   ORIGINAL ARTICLE Pages: 17 - 23

4. Allosteric effectors of hemoglobin as modulators of chemotherapy and radiation therapy in vitro and in vivo

   • Beverly A. Teicher
   • Julia S. Wong
   • David Buxton

   ORIGINAL ARTICLE Pages: 24 - 30

5. FK317: a novel substituted dihydrobenzoxazine with potent antitumor activity which does not induce vascular leak syndrome

   • Yoshinori Naoe
   • Masamichi Inami
   • Kyoichi Shimomura

   ORIGINAL ARTICLE Pages: 31 - 36

6. Renal toxicity of the neuron-blocking and mitochondriotropic agent m-iodobenzylguanidine

   • Annemieke Kuin
   • Marjanka Aalders
   • Lou A. Smets

   ORIGINAL ARTICLE Pages: 37 - 45

7. Influence of treatment with aminoglutethimide on plasma and red-blood-cell glutathione status in breast cancer patients

   • Hildegunn Berntsen
   • Per Eystein Lønning
   • Asbjørn Svardal

   ORIGINAL ARTICLE Pages: 46 - 52

8. Irinotecan (CPT-11) in combination with weekly administration of cisplatin (CDDP) for non-small-cell lung cancer

   • Kunihiko Kobayashi
   • Ayako Shinbara
   • Shouji Kudoh

   ORIGINAL ARTICLE Pages: 53 - 58

9. Comparative studies between the effects of mitozolomide and two novel tetrazepinones PYRCL and QUINCL on NIH:OVCAR-3 cells

   • Bertrand Jacques Jean-Claude
   • Amir Mustafa
   • Brian Leyland-Jones

   ORIGINAL ARTICLE Pages: 59 - 67

10. Tomudex (ZD1694, NSC 639186) in platinum-pretreated recurrent epithelial ovarian cancer: a phase II study by the Gynecologic Oncology Group

    • Franco M. Muggia
    • John A. Blessing
    • Joel Sorosky

    ORIGINAL ARTICLE Pages: 68 - 70

11. Metabolism, excretion and pharmacokinetics of a single dose of [14C]-raltitrexed in cancer patients

    • P. Beale
    • I. Judson
    • M. Walker

    ORIGINAL ARTICLE Pages: 71 - 76

12. Apoptosis- and necrosis-inducing potential of cladribine, cytarabine, cisplatin, and 5-fluorouracil in vitro: a quantitative pharmacodynamic model

    • Henk-Jan Guchelaar
    • Istvan Vermes
    • Clemens Haanen

    ORIGINAL ARTICLE Pages: 77 - 83

13. Phase I clinical and pharmacokinetic study of oral 9-aminocamptothecin (NSC-603071)

    • Sridhar Mani
    • Lalitha Iyer
    • Mark J. Ratain

    SHORT COMMUNICATION Pages: 84 - 87