1. Circular RNAs in EMT-driven metastasis regulation: modulation of cancer cell plasticity, tumorigenesis and therapy resistance

   • Milad Ashrafizadeh
   • Jingyuan Dai
   • Minglin Zhu

   Review Open access 11 May 2024 Article: 214

   

2. Deciphering the function of the fifth class of Gα proteins: regulation of ionic homeostasis as unifying hypothesis

   • Asmaa Abu Obaid
   • Ivan Ivandic
   • Sigrun I. Korsching

   Original Article Open access 10 May 2024 Article: 213

   

3. Loss of PBX1 function in Leydig cells causes testicular dysgenesis and male sterility

   • Fei-Chen Wang
   • Xiao-Na Zhang
   • Qi-En Yang

   Original Article Open access 09 May 2024 Article: 212

   

4. USP11 regulates proliferation and apoptosis of human spermatogonial stem cells via HOXC5-mediated canonical WNT/β-catenin signaling pathway

   • Jun Gao
   • Zhipeng Xu
   • Leye He

   Original Article Open access 09 May 2024 Article: 211

   

5. The IMPDH cytoophidium couples metabolism and fetal development in mice

   • Min Peng
   • Gerson D. Keppeke
   • Li-Ying Sung

   Original Article Open access 08 May 2024 Article: 210

   

6. Physiological and pathological functions of TMEM106B in neurodegenerative diseases

   • Min Zhu
   • Guoxin Zhang
   • Zhentao Zhang

   Review Open access 06 May 2024 Article: 209

   

7. PRDM14 extinction enables the initiation of trophoblast stem cell formation

   • Chunfang Xu
   • Weijie Zhao
   • Meirong Du

   Original Article Open access 06 May 2024 Article: 208

   

8. Initiation of acute pancreatitis in mice is independent of fusion between lysosomes and zymogen granules

   • Lukas Zierke
   • Daniel John
   • Ali A. Aghdassi

   Original Article Open access 06 May 2024 Article: 207

   

9. LPS-induced monocarboxylate transporter-1 inhibition facilitates lactate accumulation triggering epithelial-mesenchymal transformation and pulmonary fibrosis

   • Jinhua Feng
   • Han Zhong
   • Zhengyu He

   Original Article Open access 06 May 2024 Article: 206

   

10. Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl₃ model

    • Xueying Jin
    • Xueling Yue
    • Xian Wu Cheng

    Original Article Open access 04 May 2024 Article: 205

    

11. SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1

    • Xinxin Jin
    • Xulei Sun
    • Hongzhi Sun

    Original Article 03 May 2024 Article: 204

    

12. Rv2231c, a unique histidinol phosphate aminotransferase from Mycobacterium tuberculosis, supports virulence by inhibiting host-directed defense

    • Sheeba Zarin
    • Mohd. Shariq
    • Nasreen Zafar Ehtesham

    Original Article Open access 02 May 2024 Article: 203

    

13. Functional implications of NHR-210 enrichment in C. elegans cephalic sheath glia: insights into metabolic and mitochondrial disruptions in Parkinson's disease models

    • Rohil Hameed
    • Anam Naseer
    • Aamir Nazir

    Original Article Open access 01 May 2024 Article: 202

    

14. Update in genetic and epigenetic causes of hypertension

    • Arya Mani

    Invited review Open access 30 April 2024 Article: 201

    

15. Delineating the heterogeneity of senescence-induced-functional alterations in hepatocytes

    • Pavitra Kumar
    • Mohsin Hassan
    • Cornelius Engelmann

    Original Article Open access 30 April 2024 Article: 200

    

16. Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling

    • Irene Bodega-Mayor
    • Pablo Delgado-Wicke
    • Elena Fernández-Ruiz

    Original Article Open access 29 April 2024 Article: 199

    

17. Molecular mechanisms and therapeutic strategies for neuromuscular diseases

    • Zambon Alberto Andrea
    • Falzone Yuri Matteo
    • Previtali Stefano Carlo

    Review Open access 28 April 2024 Article: 198

    

18. Engineered platforms for mimicking cardiac development and drug screening

    • Madison Stiefbold
    • Haokang Zhang
    • Leo Q. Wan

    Review Open access 25 April 2024 Article: 197

    

19. Telomerase is essential for cardiac differentiation and sustained metabolism of human cardiomyocytes

    • Shambhabi Chatterjee
    • Megan Leach-Mehrwald
    • Christian Bär

    Original Article Open access 24 April 2024 Article: 196

    

20. Regulation of Notch signaling by non-muscle myosin II Zipper in Drosophila

    • Dipti Verma
    • Ankita Singh
    • Ashim Mukherjee

    Original Article Open access 24 April 2024 Article: 195

    

21. Recent advances in mechanisms ensuring the pairing, synapsis and segregation of XY chromosomes in mice and humans

    • Matteo Lampitto
    • Marco Barchi

    Review Open access 23 April 2024 Article: 194

    

22. The α-tubulin acetyltransferase ATAT1: structure, cellular functions, and its emerging role in human diseases

    • Angela Iuzzolino
    • Francesca Romana Pellegrini
    • Daniela Trisciuoglio

    Review Open access 23 April 2024 Article: 193

    

23. Involvement of the glymphatic/meningeal lymphatic system in Alzheimer’s disease: insights into proteostasis and future directions

    • Kaoru Yamada
    • Takeshi Iwatsubo

    Review Open access 23 April 2024 Article: 192

    

24. Flotillins affect LPS-induced TLR4 signaling by modulating the trafficking and abundance of CD14

    • Orest V. Matveichuk
    • Anna Ciesielska
    • Katarzyna Kwiatkowska

    Original Article Open access 23 April 2024 Article: 191

    

25. Dietary cysteine and methionine promote peroxisome elevation and fat loss by induction of CG33474 expression in Drosophila adipose tissue

    • Meng Liu
    • Li He

    Original Article Open access 22 April 2024 Article: 190

    

26. Adipose-derived stem cells promote glycolysis and peritoneal metastasis via TGF-β1/SMAD3/ANGPTL4 axis in colorectal cancer

    • Chaojun Zhu
    • Lan Teng
    • Qiuhua Lai

    Original Article Open access 21 April 2024 Article: 189

    

27. Vascular mimicry as a facilitator of melanoma brain metastasis

    • Olivia K. Provance
    • Victor O. Oria
    • Lucia B. Jilaveanu

    Original Article Open access 18 April 2024 Article: 188

    

28. Role of transient receptor potential ankyrin 1 in idiopathic pulmonary fibrosis: modulation of M2 macrophage polarization

    • Yi Yang
    • Zhenyu Xiao
    • Yuan Luo

    Original Article Open access 18 April 2024 Article: 187

    

29. Dodecyl creatine ester therapy: from promise to reality

    • Aloïse Mabondzo
    • Jiddeke van de Kamp
    • Saadet Mercimek-Andrews

    Visions and reflections Open access 17 April 2024 Article: 186

    

30. When DNA-damage responses meet innate and adaptive immunity

    • Jie Tong
    • Jiangwei Song
    • Chunfu Zheng

    Review Open access 17 April 2024 Article: 185

    

31. The impact of nanomaterials on autophagy across health and disease conditions

    • Ida Florance
    • Marco Cordani
    • Natarajan Chandrasekaran

    Review Open access 17 April 2024 Article: 184

    

32. RUNX transcription factors are essential in maintaining epididymal epithelial differentiation

    • Mervi Toriseva
    • Ida Björkgren
    • Petra Sipilä

    Original Article Open access 17 April 2024 Article: 183

    

33. Linc-NSC affects cell differentiation, apoptosis and proliferation in mouse neural stem cells and embryonic stem cells in vitro and in vivo

    • Lili Guo
    • Dan Zou
    • Ruxiang Xu

    Original Article Open access 14 April 2024 Article: 182

    

34. Functional myelin in cognition and neurodevelopmental disorders

    • Hasni Khelfaoui
    • Cristobal Ibaceta-Gonzalez
    • Maria Cecilia Angulo

    Review Open access 13 April 2024 Article: 181

    

35. Identification of the role of DAB2 and CXCL8 in uterine spiral artery remodeling in early-onset preeclampsia

    • Yu Liu
    • Lili Du
    • Jingsi Chen

    Original Article Open access 13 April 2024 Article: 180

    

36. Tumor-associated macrophage-derived exosomal miR21-5p promotes tumor angiogenesis by regulating YAP1/HIF-1α axis in head and neck squamous cell carcinoma

    • Quan Yan
    • Jing Liu
    • Lu Gao

    Original Article Open access 11 April 2024 Article: 179

    

37. Epigenomic insights into common human disease pathology

    • Christopher G. Bell

    Review Open access 11 April 2024 Article: 178

    

38. Sex differences in DNA methylation across gestation: a large scale, cross-cohort, multi-tissue analysis

    • Darina Czamara
    • Linda Dieckmann
    • Sonja Entringer

    Original Article Open access 10 April 2024 Article: 177

    

39. A novel fatty acid analogue triggers CD36–GPR120 interaction and exerts anti-inflammatory action in endotoxemia

    • Pierre-Marie Boutanquoi
    • Amira Sayed Khan
    • Naim Akhtar Khan

    Original Article Open access 10 April 2024 Article: 176

    

40. LncRNA CARMN inhibits abdominal aortic aneurysm formation and vascular smooth muscle cell phenotypic transformation by interacting with SRF

    • Shenrong Liu
    • Haobin Zhou
    • Zheng Huang

    Original Article Open access 10 April 2024 Article: 175

    

41. CCDC28A deficiency causes sperm head defects, reduced sperm motility and male infertility in mice

    • Hongbin Zhou
    • Zhihua Zhang
    • Lei Wang

    Original Article Open access 10 April 2024 Article: 174

    

42. PALB2-mutated human mammary cells display a broad spectrum of morphological and functional abnormalities induced by increased TGFβ signaling

    • Hanna Tuppurainen
    • Niina Laurila
    • Hellevi Peltoketo

    Original Article Open access 10 April 2024 Article: 173

    

43. Bioengineered MSC^Cxcr2 transdifferentiated keratinocyte-like cell-derived organoid potentiates skin regeneration through ERK1/2 and STAT3 signaling in diabetic wound

    • Subholakshmi Choudhury
    • Neha R. Dhoke
    • Amitava Das

    Original Article Open access 10 April 2024 Article: 172

    

44. The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation

    • Max Zachrisson Totland
    • Lars Mørland Knudsen
    • Edward Leithe

    Original Article Open access 10 April 2024 Article: 171

    

45. Metabolic profiling identifies Qrich2 as a novel glutamine sensor that regulates microtubule glutamylation and mitochondrial function in mouse sperm

    • Guohui Zhang
    • Juncen Guo
    • Wenming Xu

    Original Article Open access 10 April 2024 Article: 170

    

46. Rhes, a striatal enriched protein, regulates post-translational small-ubiquitin-like-modifier (SUMO) modification of nuclear proteins and alters gene expression

    • Oscar Rivera
    • Manish Sharma
    • Srinivasa Subramaniam

    Original Article Open access 08 April 2024 Article: 169

    

47. Kinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosis

    • Jing-Cai Liu
    • Zhen-Nan Pan
    • Shao-Chen Sun

    Original Article Open access 08 April 2024 Article: 168

    

48. NFKBIZ regulates NFκB signaling pathway to mediate tumorigenesis and metastasis of hepatocellular carcinoma by direct interaction with TRIM16

    • Danfeng Guo
    • Ming Zhang
    • Wenzhi Guo

    Original Article Open access 06 April 2024 Article: 167

    

49. Unearthing FLVCR1a: tracing the path to a vital cellular transporter

    • Veronica Fiorito
    • Emanuela Tolosano

    Review Open access 06 April 2024 Article: 166

    

50. CRL4^DCAF13 E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes

    • Peipei Ren
    • Xiaomei Tong
    • Yin-Li Zhang

    Original Article Open access 05 April 2024 Article: 165