From genomics to disease mechanisms

In this topical collection (15 articles)

1. Review

   Approaches for establishing the function of regulatory genetic variants involved in disease

   Julian Charles Knight Article:92

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2. Review

   Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations

   Yun R Li, Brendan J Keating Article:91

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3. Research

   Reducing INDEL calling errors in whole genome and exome sequencing data

   Han Fang, Yiyang Wu, Giuseppe Narzisi, Jason A ORawe… Article:89

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4. Research

   Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity

   Barbara Hrdlickova, Vinod Kumar, Kartiek Kanduri, Daria V Zhernakova… Article:88

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5. Review

   Computational approaches to interpreting genomic sequence variation

   Graham RS Ritchie, Paul Flicek Article:87

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6. Editorial

   Life after genetics

   Jay Shendure Article:86

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7. Review

   Enhancer variants: evaluating functions in common disease

   Olivia Corradin, Peter C Scacheri Article:85

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8. Research highlight

   Using genetically isolated populations to understand the genomic basis of disease

   Eleftheria Zeggini Article:83

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9. Review

   Modules, networks and systems medicine for understanding disease and aiding diagnosis

   Mika Gustafsson, Colm E Nestor, Huan Zhang, Albert-László Barabási… Article:82

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10. Research

    Functional consequences of somatic mutations in cancer using protein pocket-based prioritization approach

    Huy Vuong, Feixiong Cheng, Chen-Ching Lin, Zhongming Zhao Article:81

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11. Research

    Dual roles for immune metagenes in breast cancer prognosis and therapy prediction

    Angela Alistar, Jeff W Chou, Srikanth Nagalla, Michael A Black… Article:80

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12. Software

    SuRFing the genomics wave: an R package for prioritising SNPs by functionality

    Niamh M Ryan, Stewart W Morris, David J Porteous, Martin S Taylor… Article:79

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13. Research

    A large scale expression study associates uc.283-plus lncRNA with pluripotent stem cells and human glioma

    Marco Galasso, Paola Dama, Maurizio Previati, Sukhinder Sandhu… Article:76

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14. Research

    Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome

    Yuan Tian, Irina Voineagu, Sergiu P Paşca, Hyejung Won… Article:75

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15. Software

    VariantDB: a flexible annotation and filtering portal for next generation sequencing data

    Geert Vandeweyer, Lut Van Laer, Bart Loeys, Tim Van den Bulcke… Article:74

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