High-velocity resistance training mitigates physiological and functional impairments in middle-aged and older adults with and without mobility-limitation Gustavo Z. SchaunMarcas M. BammanCristine L. Alberton Original Article 27 January 2022 Pages: 1175 - 1197
A neuromuscular perspective of sarcopenia pathogenesis: deciphering the signaling pathways involved Alexandra Moreira-PaisRita FerreiraJosé A. Duarte Original Article 04 January 2022 Pages: 1199 - 1213
Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men Yuxiao GuoJessica PiaseckiMathew Piasecki Original Article Open access 03 December 2021 Pages: 1215 - 1228
Humoral immune response after COVID-19 infection or BNT162b2 vaccine among older adults: evolution over time and protective thresholds Maxence MeyerFlorentin ConstanciasPatrick Karcher Original Article 08 April 2022 Pages: 1229 - 1240
Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patients Ayush BatraJeffrey R. ClarkEric M. Liotta Original Article 11 May 2022 Pages: 1241 - 1254
Stringent public health measures during COVID-19 across ischemic stroke care systems: the potential impact of patient perceptions on health care-seeking behaviors Calin I. ProdanAyush BatraEric M. Liotta Original Paper 25 April 2022 Pages: 1255 - 1262
Favipiravir for the treatment of COVID-19 in elderly patients—what do we know after 2 years of COVID-19? Henrietta PappZsófia LanszkiFerenc Jakab Short Communication Open access 11 May 2022 Pages: 1263 - 1268
Poly(A) RNA sequencing reveals age-related differences in the prefrontal cortex of dogs Sára SándorDávid JónásEniko Kubinyi Original Article Open access 14 March 2022 Pages: 1269 - 1293
Untapped research opportunities in China: promising future avenues and potential concerns for aging companion animals Jessica M. HoffmanShanshan SongTeresa G. Valencak Original Article Open access 24 August 2021 Pages: 1295 - 1299
Novel immortalization approach defers senescence of cultured canine adipose-derived mesenchymal stromal cells Ana StojiljkovićVéronique GaschenJasmin Bluteau Original Article 22 November 2021 Pages: 1301 - 1323
Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study Tatsushi MutohKeiko KunitokiYasuyuki Taki Original Article 05 April 2022 Pages: 1325 - 1338
Imaging subtle leaks in the blood–brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions Axel MontagneSamuel R. BarnesBerislav V. Zlokovic Opinion Paper 25 April 2022 Pages: 1339 - 1351
The pathophysiology of chronic subdural hematoma revisited: emphasis on aging processes as key factor Ralf WeigelLothar SchillingJoachim K. Krauss Review 23 April 2022 Pages: 1353 - 1371
Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: a systematic review and meta-analysis Carlo CustoderoAlessandro CiavarellaVincenzo Solfrizzi Review Open access 29 April 2022 Pages: 1373 - 1392
Obesity as a premature aging phenotype — implications for sarcopenic obesity Emily NunanCarson L. WrightJoshua T. Butcher Review Open access 26 April 2022 Pages: 1393 - 1405
Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice Rodney M. RitzelYun LiJunfang Wu Original Article Open access 22 April 2022 Pages: 1407 - 1440
Higher white matter hyperintensity load adversely affects pre-post proximal cognitive training performance in healthy older adults Emanuel M. BoutzoukasAndrew O’SheaAdam J. Woods Original Article 12 March 2022 Pages: 1441 - 1455
Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease Luodan YangChongyun WuQuanguang Zhang Original Article 28 February 2022 Pages: 1457 - 1477
Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life Hao MaTao ZhouLu Qi Original Article 20 March 2022 Pages: 1479 - 1488
Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults Wan-Hsuan LuKelly Virecoulon Giudicifor the MAPT/DSA Group Original Article 20 April 2022 Pages: 1489 - 1503
Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity Zhizhen WangPeng ZhengXu-Feng Huang Original Article Open access 20 April 2022 Pages: 1505 - 1524
A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer’s disease Fabio MacciardiMaria Giulia BacaliniMark Mapstone Original Article Open access 19 May 2022 Pages: 1525 - 1550
Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease Chao-Wen LinTzu-Ting LaiChin-Hsien Lin Original Article 28 April 2022 Pages: 1551 - 1562
Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease Ye ZhangYasuko TatewakiYasuyuki Taki Original Article 08 May 2022 Pages: 1563 - 1574
Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases Miracle OzzoudeBrenda VarrianoMaria Carmela Tartaglia Original Article 16 March 2022 Pages: 1575 - 1598
Analysis of complexity in the EEG activity of Parkinson’s disease patients by means of approximate entropy Chiara PappaletteraFrancesca MiragliaFabrizio Vecchio Original Article 28 March 2022 Pages: 1599 - 1607
HIV, pathology and epigenetic age acceleration in different human tissues Steve HorvathDavid T. S. LinAndrew J. Levine Original Article Open access 11 April 2022 Pages: 1609 - 1620
Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment Jeremy A. WhitsonRichard JohnsonPeter S. Rabinovitch Original Article 13 April 2022 Pages: 1621 - 1639
Prediction of disability-free survival in healthy older people Johannes Tobias NeumannLe T. P. Thaoon behalf of the ASPREE investigators Original Article Open access 14 April 2022 Pages: 1641 - 1655
SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice Rogerio N. SoaresFrancisco I. Ramirez-PerezCamila Manrique-Acevedo Original Article Open access 15 April 2022 Pages: 1657 - 1675
Lipidomic signatures from physically frail and robust older adults at hospital admission Robinson Ramírez-VélezNicolás Martínez-VelillaMikel Izquierdo Original Article Open access 04 February 2022 Pages: 1677 - 1688
Interaction of aging with lipoxygenase deficiency initiates hypersplenism, cardiac dysfunction, and profound leukocyte directed non-resolving inflammation Vasundhara KainYusuf MatGanesh V. Halade Original Article 21 December 2021 Pages: 1689 - 1702
Classical risk factors for primary coronary artery disease from an aging perspective through Mendelian Randomization Swetta A. JansenBas HuiskensRaymond Noordam Original Article 21 December 2021 Pages: 1703 - 1713
Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range Ingo KilimannDiana WuchererStefan Johannes Teipel Original Article Open access 23 December 2021 Pages: 1715 - 1726
Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis Mohanraj RajeshPartha MukhopadhyayPal Pacher Original Article 22 April 2022 Pages: 1727 - 1741
Correction to: Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis Mohanraj RajeshPartha MukhopadhyayPal Pacher Correction 20 May 2022 Pages: 1743 - 1745
Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary Jéssica D. HenseDriele N. GarciaAugusto Schneider Original Article 23 April 2022 Pages: 1747 - 1759
Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation Maria E. C. BrunoSujata MukherjeeMarlene E. Starr Original Article Open access 28 April 2022 Pages: 1761 - 1778
Once-daily feeding is associated with better health in companion dogs: results from the Dog Aging Project Emily E. BrayZihan ZhengKathleen F. Kerr Original Article 28 April 2022 Pages: 1779 - 1790
Diabetic patients treated with metformin during early stages of Alzheimer’s disease show a better integral performance: data from ADNI study Carlos PomilioNicolás González PérezFlavia Saravia Original Article 20 April 2022 Pages: 1791 - 1805
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume Lidija MilicicMichael VacherAustralian Imaging Biomarkers and Lifestyle (AIBL) Study Original Article Open access 21 April 2022 Pages: 1807 - 1823
Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies Steve HorvathAmin HaghaniKaren E. Sears Original Article Open access 21 April 2022 Pages: 1825 - 1845
Vitamin D supplementation is associated with slower epigenetic aging Valentin Max VetterYasmine SommererIlja Demuth Original Article Open access 13 May 2022 Pages: 1847 - 1859
Telomere length and epigenetic clocks as markers of cellular aging: a comparative study Emily E. PearceRotana AlsaggafShahinaz M. Gadalla Original Article 18 May 2022 Pages: 1861 - 1869
Elevated skin senescence in young mice causes delayed wound healing Rex Jeya Rajkumar Samdavid ThanapaulMaria ShvedovaDaniel S. Roh Short Communication 11 April 2022 Pages: 1871 - 1878
From 1901 to 2022, how far are we from truly understanding the pathogenesis of age-related dementia? Xing FangJin ZhangFan Fan Commentary 19 May 2022 Pages: 1879 - 1883
Correction to: Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration Jae-Byoung ChaeHyoik JangHyewon Chung Correction 16 March 2022 Pages: 1885 - 1885
Correction to: Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints Ricardo BajoNazareth P. CastellanosFernando Maestu Correction 23 March 2022 Pages: 1887 - 1887
Correction to: Pterocarpus marsupium extract extends replicative lifespan in budding yeast Mitchell B. LeeMichael G. KiflezghiMatt Kaeberlein Correction 23 March 2022 Pages: 1889 - 1889