Lack of resemblance between Myhre syndrome and other “segmental progeroid” syndromes warrants restraint in applying this classification Angela E. LinNicola Brunetti-Pierrithe Myhre Syndrome Foundation Professional Advisory Board Letter to the Editor 25 February 2021 Pages: 459 - 461
A ride through the epigenetic landscape: aging reversal by reprogramming Lucas Paulo de Lima CamilloRobert B. A. Quinlan Review Open access 06 April 2021 Pages: 463 - 485
Current perspectives on the clinical implications of oxidative RNA damage in aging research: challenges and opportunities Zhijie XuJinzhou HuangYuanliang Yan Review Article 11 June 2020 Pages: 487 - 505
Implication of post-translationally modified SOD1 in pathological aging Kashfia ShafiqNitesh SanghaiJiming Kong Review 19 February 2021 Pages: 507 - 515
Targeting mitochondrial dysfunction with small molecules in intervertebral disc aging and degeneration Morteza SaberiXiaolei ZhangAli Mobasheri Review Open access 26 February 2021 Pages: 517 - 537
IL-6 can singlehandedly drive many features of frailty in mice Mladen JergovićHeather L. ThompsonJanko Nikolich-Žugich Original Article 24 February 2021 Pages: 539 - 549
Longitudinal uncoupling of the heart and arteries with aging in a community-dwelling population Majd AlGhatrifChris H. MorrellEdward G. Lakatta Original Article 18 February 2021 Pages: 551 - 561
Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model Rheal A. TownerRafal GulejArlan Richardson Original Article 13 April 2021 Pages: 563 - 578
C60 in olive oil causes light-dependent toxicity and does not extend lifespan in mice Kristopher J. GrohnBrandon S. MoyerKelsey J. Moody Original Article 29 October 2020 Pages: 579 - 591
Protein signatures from blood plasma and urine suggest changes in vascular function and IL-12 signaling in elderly with a history of chronic diseases compared with an age-matched healthy cohort Yanbao YuHarinder SinghRembert Pieper Original Article 24 September 2020 Pages: 593 - 606
Effects of 16 months of high intensity resistance training on thigh muscle fat infiltration in elderly men with osteosarcopenia Mansour GhasemikaramOliver ChaudryKlaus Engelke Original Article 15 January 2021 Pages: 607 - 617
Age-associated difference in circulating ACE2, the gateway for SARS-COV-2, in humans: results from the InCHIANTI study Majd AlGhatrifToshiko TanakaLuigi Ferrucci Original Article 18 January 2021 Pages: 619 - 627
Associations of muscle lipid content with physical function and resistance training outcomes in older adults: altered responses with metformin Douglas E. LongBailey D. PeckRosicka G. Walton Original Article 18 January 2021 Pages: 629 - 644
Dynamics of leukocyte telomere length in adults aged 50 and older: a longitudinal population-based cohort study Zhezhou HuangChazhen LiuFan Wu Original Article 19 January 2021 Pages: 645 - 654
The relative contributions of behavioral, biological, and psychological risk factors in the association between psychosocial stress and all-cause mortality among middle- and older-aged adults in the USA Justin RodgersAdolfo G. CuevasS.V. Subramanian Original Article 28 January 2021 Pages: 655 - 672
Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length Alexander WirthBettina WolfEvgeni Ponimaskin Original Article Open access 31 January 2021 Pages: 673 - 690
A novel role of the mitochondrial iron-sulfur cluster assembly protein ISCU-1/ISCU in longevity and stress response Yi ShengGuang YangRui Xiao Original Article 01 February 2021 Pages: 691 - 707
Age-related compositional changes and correlations of gut microbiome, serum metabolome, and immune factor in rats Xia ZhangYuping YangXiaoyan Wang Original Article 17 May 2020 Pages: 709 - 725
Identification of biomarkers for physical frailty and sarcopenia through a new multi-marker approach: results from the BIOSPHERE study Riccardo CalvaniAnna PiccaEmanuele Marzetti Original Article 01 June 2020 Pages: 727 - 740
Regular endurance exercise of overloaded muscle of young and old male mice does not attenuate hypertrophy and improves fatigue resistance Paul William HendrickseRaulas KrusnauskasHans Degens Original Article Open access 08 July 2020 Pages: 741 - 757
5′-Hydroxy-6, 7, 8, 3′, 4′-pentamethoxyflavone extends longevity mediated by DR-induced autophagy and oxidative stress resistance in C. elegans Shalini TrivediRakesh Pandey Original Article 17 July 2020 Pages: 759 - 772
Plasma exosomes characterization reveals a perioperative protein signature in older patients undergoing different types of on-pump cardiac surgery Alessandro CarrozzoValentina CasieriVincenzo Lionetti Original Article 20 July 2020 Pages: 773 - 789
Hemiterpene compound, 3,3-dimethylallyl alcohol promotes longevity and neuroprotection in Caenorhabditis elegans Suresh Chandra PhularaSwapnil PandeyVirendra Shukla Original Article 28 July 2020 Pages: 791 - 807
Sex differences in changes of protein synthesis with rapamycin treatment are minimized when metformin is added to rapamycin Christopher A. WolffMarcus M. LawrenceBenjamin F. Miller Original Article 05 August 2020 Pages: 809 - 828
Mapping the multicausality of Alzheimer’s disease through group model building Jeroen F. UlemanRené J. F. MelisMarcel G. M. Olde Rikkert Original Article Open access 11 August 2020 Pages: 829 - 843
N-terminal pro B-type natriuretic peptide (NT-proBNP): a possible surrogate of biological age in the elderly people Antonio MuscariGiampaolo BianchiThe Pianoro Study Group Original Article Open access 11 August 2020 Pages: 845 - 857
Ageing human bone marrow mesenchymal stem cells have depleted NAD(P)H and distinct multispectral autofluorescence Jared M. CampbellSaabah MahbubEwa Goldys Original Article 13 August 2020 Pages: 859 - 868
Handgrip strength—a risk indicator for future fractures in the general population: findings from a prospective study and meta-analysis of 19 prospective cohort studies Setor K. KunutsorSamuel SeiduJari A. Laukkanen Original Article Open access 19 August 2020 Pages: 869 - 880
Treatment with a DC-SIGN ligand reduces macrophage polarization and diastolic dysfunction in the aging female but not male mouse hearts JoAnn TrialRodrigo Diaz LankenauKatarzyna A. Cieslik Original Article Open access 26 August 2020 Pages: 881 - 899
IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging Stefano TarantiniPriya BalasubramanianZoltan Ungvari Original Article 06 March 2021 Pages: 901 - 911
The retention of fall-resisting behavior derived from treadmill slip-perturbation training in community-dwelling older adults Xuan LiuTanvi BhattYi-Chung Pai Original Article 25 September 2020 Pages: 913 - 926
Age-dependent modulation of bone metabolism in zebrafish scales as new model of male osteoporosis in lower vertebrates Marta CarnovaliGiuseppe BanfiMassimo Mariotti Original Article Open access 30 September 2020 Pages: 927 - 940
High-resolution yeast quiescence profiling in human-like media reveals complex influences of auxotrophy and nutrient availability Sean M. SantosSamantha LaflinJohn L. Hartman IV Original Article 05 October 2020 Pages: 941 - 964
I2 imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway Foteini VasilopoulouChristian Griñán-FerréMercè Pallàs Original Article 31 October 2020 Pages: 965 - 983
Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer’s disease in comparison with healthy aging Maria ConteJacopo SabbatinelliStefano Salvioli Original Article Open access 31 October 2020 Pages: 985 - 1001
Late-onset depression is associated to age-related central auditory processing disorder in an older population in Southern Italy Madia LozuponeRodolfo SardoneFrancesco Panza Original Article 31 October 2020 Pages: 1003 - 1014
Association between telomere length, frailty and death in older adults Mariam El AssarJavier AnguloLeocadio Rodríguez-Mañas Original Article 15 November 2020 Pages: 1015 - 1027
Characterization of the plasma proteomic profile of frailty phenotype Kristina LandinoToshiko TanakaLuigi Ferrucci Original Article 17 November 2020 Pages: 1029 - 1037
Biomarkers and phenotypic expression in Alzheimer’s disease: exploring the contribution of frailty in the Alzheimer’s Disease Neuroimaging Initiative Marco CanevelliIvan Arisifor the Alzheimer’s Disease Neuroimaging Initiative Original Article Open access 19 November 2020 Pages: 1039 - 1051
Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study Angelo Di IorioRoberto PaganelliFrancesca Cecchi Original Article Open access 21 November 2020 Pages: 1053 - 1064
Reversal of cerebral hypoperfusion: a novel therapeutic target for the treatment of AD/ADRD? Fan FanRichard J. Roman Commentary 27 March 2021 Pages: 1065 - 1067