Volume 15, Issue 2

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May 2011

Special issue on Molecular Diversity and Natural Products

Issue Editors:

Giovanni Appendino,
Luca Banfi

28 articles in this issue

Molecular diversity and natural products
Giovanni Appendino
Luca Banfi
Editorial 21 April 2011 Pages: 291 - 292
Natural products as DNA methyltransferase inhibitors: a computer-aided discovery approach
Jose L. Medina-Franco
Fabian López-Vallejo
Frank Lyko
Full-length Paper 10 August 2010 Pages: 293 - 304
Carbonic anhydrase inhibition with natural products: novel chemotypes and inhibition mechanisms
Claudiu T. Supuran
Full-Length Paper 28 August 2010 Pages: 305 - 316
Libraries of 2β-(N-substituted piperazino)-5α-androstane-3α, 17β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes
Jenny Roy
René Maltais
Donald Poirier
Full-Length Paper 09 September 2010 Pages: 317 - 339
Ultrasonic assisted Fischer glycosylation: generating diversity for glycochemistry
Nasrin Shaikh
Laura Russo
Francesco Nicotra
Full-Length Paper 08 October 2010 Pages: 341 - 345
Design, synthesis and activity evaluation of mannose-based DC-SIGN antagonists
Nataša Obermajer
Sara Sattin
Anna Bernardi
Full-Length Paper 14 November 2010 Pages: 347 - 360
HPLC-based activity profiling for GABA_A receptor modulators from the traditional Chinese herbal drug Kushen (Sophora flavescens root)
Xinzhou Yang
Igor Baburin
Matthias Hamburger
Full-Length Paper 05 January 2011 Pages: 361 - 372
Silica sulfuric acid as mild and efficient catalyst for the preparation of poly-hydroxyl aromatic compounds under mild and heterogeneous conditions
Ali Khalafi-Nezhad
Abolfath Parhami
Habib Foroughi
Full-Length Paper 22 February 2011 Pages: 373 - 381
Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives
Karl-Heinz Altmann
Fabienne Z. Gaugaz
Raphael Schiess
Comprehensive Review 01 January 2011 Pages: 383 - 399
Chemical biology of Histone acetyltransferase natural compounds modulators
Fabrizio Dal Piaz
Antonio Vassallo
Nunziatina De Tommasi
Comprehensive Review 01 January 2011 Pages: 401 - 416
Quantitative structure–activity relationship study of antitubercular fluoroquinolones
Nikola Minovski
Marjan Vračko
Tom Šolmajer
Full-length paper 14 March 2010 Pages: 417 - 426
Prediction of mucin-type O-glycosylation sites by a two-staged strategy
YuDong Cai
JianFeng He
Lin Lu
Full-Length Paper 22 July 2010 Pages: 427 - 433
Predictive models for nucleoside bisubstrate analogs as inhibitors of siderophore biosynthesis in Mycobacterium tuberculosis: pharmacophore mapping and chemometric QSAR study
Nilesh R. Tawari
Mariam S. Degani
Full-length paper 21 March 2010 Pages: 435 - 444
A mild and efficient method for the synthesis of a new class of furo[3,2-c]chromenes in aqueous media
Mohammad A. Khalilzadeh
Zinatossadat Hossaini
Mehdi Rajabi
Full-Length Paper 25 August 2010 Pages: 445 - 450
Domino Michael–O-alkylation: one-pot synthesis of dialkyl 4-oxo-2,3-dihydro-2,3-furandicarboxylates
Issa Yavari
Mehdi Sirouspour
Sanaz Souri
Full-Length Paper 10 September 2010 Pages: 451 - 456
CoMFA and CoMSIA of diverse pyrrolidine analogues as dipeptidyl peptidase IV inhibitors: active site requirements
Vanangamudi Murugesan
Nidhi Sethi
Seturam B. Katti
Full-length paper 25 August 2010 Pages: 457 - 466
Oral LD₅₀ toxicity modeling and prediction of per- and polyfluorinated chemicals on rat and mouse
Barun Bhhatarai
Paola Gramatica
Full-Length Paper 28 August 2010 Pages: 467 - 476
Integration-mediated prediction enrichment of quantitative model for Hsp90 inhibitors as anti-cancer agents: 3D-QSAR study
Kuldeep K. Roy
Supriya Singh
Anil K. Saxena
Full-Length Paper 26 August 2010 Pages: 477 - 489
One-pot microwave-assisted protocol for the synthesis of substituted 2-amino-1H-imidazoles
D. S. Ermolat’ev
B. Savaliya
E. Van der Eycken
Full-Length Paper 26 August 2010 Pages: 491 - 496
A diversity-oriented synthesis of pyrazolo[4,3-f]quinoline derivatives with potential bioactivities via microwave-assisted multi-component reactions
Feng Shi
Shu Zhang
Shu-Jiang Tu
Full-Length Paper 03 September 2010 Pages: 497 - 505
Novel coumarin-based tyrosinase inhibitors discovered by OECD principles-validated QSAR approach from an enlarged, balanced database
Huong Le-Thi-Thu
Gerardo M. Casañola-Martín
Concepción Abad
Full-Length Paper 03 September 2010 Pages: 507 - 520
A novel four-component reaction for the synthesis of disubstituted 1,3,4-oxadiazole derivatives
Ali Ramazani
Nahid Shajari
Yavar Ahmadi
Full-length paper 03 September 2010 Pages: 521 - 527
A multicomponent approach to the synthesis of 1,3-dicarbonylic compounds
Ana G. Neo
Rosa M. Carrillo
Carlos F. Marcos
Full-length paper 03 September 2010 Pages: 529 - 539
Synthesis of bis-peptides attached on poly[n]norbornene molecular scaffolds with well-defined relative positions and distances
Muhong Shang
Ronald N. Warrener
Davor Margetić
Full-Length Paper 21 September 2010 Pages: 541 - 560
First computational chemistry multi-target model for anti-Alzheimer, anti-parasitic, anti-fungi, and anti-bacterial activity of GSK-3 inhibitors in vitro, in vivo, and in different cellular lines
Isela García
Yagamare Fall
Humberto González-Díaz
Full-Length Paper 08 October 2010 Pages: 561 - 567
Traceless synthesis of diketopiperazine fused tetrahydro-β-carbolines on soluble polymer support
Kaushik Chanda
Cheng-Ting Chou
Chung-Ming Sun
Full-length paper 10 October 2010 Pages: 569 - 581
Novel and efficient one-pot five- and six-component reactions for the stereoselective synthesis of highly functionalized enaminones and dithiocarbamates
Morteza Bararjanian
Saeed Balalaie
Hamid Reza Bijanzadeh
Full-Length Paper 12 November 2010 Pages: 583 - 594
A diversity-oriented synthesis of 3-(2-amino-1,6-dihydro-6-oxo-pyrimidin-5-yl)propanoic esters
Xavier Berzosa
Sofia Pettersson
José I. Borrell
Full-Length Paper 12 November 2010 Pages: 595 - 601

Volume 15, Issue 2

Molecular diversity and natural products

Natural products as DNA methyltransferase inhibitors: a computer-aided discovery approach

Carbonic anhydrase inhibition with natural products: novel chemotypes and inhibition mechanisms

Libraries of 2β-(N-substituted piperazino)-5α-androstane-3α, 17β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes

Ultrasonic assisted Fischer glycosylation: generating diversity for glycochemistry

Design, synthesis and activity evaluation of mannose-based DC-SIGN antagonists

HPLC-based activity profiling for GABA_A receptor modulators from the traditional Chinese herbal drug Kushen (Sophora flavescens root)

Silica sulfuric acid as mild and efficient catalyst for the preparation of poly-hydroxyl aromatic compounds under mild and heterogeneous conditions

Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives

Chemical biology of Histone acetyltransferase natural compounds modulators

Quantitative structure–activity relationship study of antitubercular fluoroquinolones

Prediction of mucin-type O-glycosylation sites by a two-staged strategy

Predictive models for nucleoside bisubstrate analogs as inhibitors of siderophore biosynthesis in Mycobacterium tuberculosis: pharmacophore mapping and chemometric QSAR study

A mild and efficient method for the synthesis of a new class of furo[3,2-c]chromenes in aqueous media

Domino Michael–O-alkylation: one-pot synthesis of dialkyl 4-oxo-2,3-dihydro-2,3-furandicarboxylates

CoMFA and CoMSIA of diverse pyrrolidine analogues as dipeptidyl peptidase IV inhibitors: active site requirements

Oral LD₅₀ toxicity modeling and prediction of per- and polyfluorinated chemicals on rat and mouse

Integration-mediated prediction enrichment of quantitative model for Hsp90 inhibitors as anti-cancer agents: 3D-QSAR study

One-pot microwave-assisted protocol for the synthesis of substituted 2-amino-1H-imidazoles

A diversity-oriented synthesis of pyrazolo[4,3-f]quinoline derivatives with potential bioactivities via microwave-assisted multi-component reactions

Novel coumarin-based tyrosinase inhibitors discovered by OECD principles-validated QSAR approach from an enlarged, balanced database

A novel four-component reaction for the synthesis of disubstituted 1,3,4-oxadiazole derivatives

A multicomponent approach to the synthesis of 1,3-dicarbonylic compounds

Synthesis of bis-peptides attached on poly[n]norbornene molecular scaffolds with well-defined relative positions and distances

First computational chemistry multi-target model for anti-Alzheimer, anti-parasitic, anti-fungi, and anti-bacterial activity of GSK-3 inhibitors in vitro, in vivo, and in different cellular lines

Traceless synthesis of diketopiperazine fused tetrahydro-β-carbolines on soluble polymer support

Novel and efficient one-pot five- and six-component reactions for the stereoselective synthesis of highly functionalized enaminones and dithiocarbamates

A diversity-oriented synthesis of 3-(2-amino-1,6-dihydro-6-oxo-pyrimidin-5-yl)propanoic esters

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