1. A Comment on the Application of Drug Tissue-Plasma Partition Coefficients K _p in Eliminating Organs to Calculation of Volume of Distribution at Steady State

   • Sven Björkman

   OriginalPaper Pages: 655 - 658

2. A Comment on the “Correction” of Tissue–Plasma Partition Coefficients for Drug Extraction in Eliminating Organs by Sven Björkman

   • Ivelina Gueorguieva
   • Malcolm Rowland

   OriginalPaper Pages: 659 - 662

3. A Mathematical Model for Paroxetine Antidepressant Effect Time Course and Its Interaction with Pindolol

   • Berangere Gruwez
   • Alain Dauphin
   • Michel Tod

   OriginalPaper Pages: 663 - 683

4. Sample Size Computations for PK/PD Population Models

   • Dongwoo Kang
   • Janice B. Schwartz
   • Davide Verotta

   OriginalPaper Pages: 685 - 701

5. Inherent Correlation Between Dose and Clearance in Therapeutic Drug Monitoring Settings: Possible Misinterpretation in Population Pharmacokinetic Analyses

   • Jae Eun Ahn
   • Angela K. Birnbaum
   • Richard C. Brundage

   OriginalPaper Pages: 703 - 718

6. Lumping in Pharmacokinetics

   • Céline Brochot
   • János Tóth
   • Frédéric Y. Bois

   OriginalPaper Pages: 719 - 736

7. Optimal Blood Sampling Time Windows for Parameter Estimation Using a Population Approach: Design of a Phase II Clinical Trial

   • Marylore Chenel
   • Kayode Ogungbenro
   • Leon Aarons

   OriginalPaper Pages: 737 - 756

8. Estimation of AUC from 0 to Infinity in Serial Sacrifice Designs

   • Martin Josef Wolfsegger
   • Thomas Jaki

   OriginalPaper Pages: 757 - 766

9. Population Cell Life Span Models for Effects of Drugs Following Indirect Mechanisms of Action

   • Juan J. Perez-Ruixo
   • Hui C. Kimko
   • William J. Jusko

   OriginalPaper Pages: 767 - 793

10. A Longitudinal Model for Non-Monotonic Clinical Assessment Scale Data

    • Fredrik Jonsson
    • Scott Marshall
    • E. Niclas Jonsson

    OriginalPaper Pages: 795 - 815

11. Pharmacokinetic Modelling of 5-FU Production from Capecitabine—A Population Study in 40 Adult Patients with Metastatic Cancer

    • Saik Urien
    • Keyvan Rezaí
    • François Lokiec

    OriginalPaper Pages: 817 - 833

12. A Pharmacodynamic Turnover Model Capturing Asymmetric Circadian Baselines of Body Temperature, Heart Rate and Blood Pressure in Rats: Challenges in Terms of Tolerance and Animal-handling Effects

    • Björn Sällström
    • Sandra A. G. Visser
    • Johan Gabrielsson

    OriginalPaper Pages: 835 - 859