1. Guest Editor

   Acknowledgments 09 December 2006 Pages: 503 - 503

2. Bone metastasis and cancer

   • Kenneth J. Pienta

   PREFACE 12 December 2006 Pages: 505 - 505

3. Recent advances in the detection of bone marrow micrometastases: A promising area for research or just another false hope? A review of the literature

   • Pauline Athanassiadou
   • Dimitra Grapsa

   OriginalPaper 09 December 2006 Pages: 507 - 519

4. Bone marrow cells in the ‘pre-metastatic niche’: within bone and beyond

   • Rosandra N. Kaplan
   • Bethan Psaila
   • David Lyden

   OriginalPaper 22 December 2006 Pages: 521 - 529

5. Intravascular cell-to-cell adhesive interactions and bone metastasis

   • Vladislav V. Glinsky

   OriginalPaper 14 December 2006 Pages: 531 - 540

6. The RANK/RANKL/OPG triad in cancer-induced bone diseases

   • William C. Dougall
   • Michelle Chaisson

   OriginalPaper 19 December 2006 Pages: 541 - 549

7. The role of Wnts in bone metastases

   • Christopher L. Hall
   • Evan T. Keller

   OriginalPaper 09 December 2006 Pages: 551 - 558

8. Skeletal metastasis: Established and emerging roles of parathyroid hormone related protein (PTHrP)

   • Jinhui Liao
   • Laurie K. McCauley

   OriginalPaper 13 December 2006 Pages: 559 - 571

9. The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasis

   • Jianhua Wang
   • Robert Loberg
   • Russell S. Taichman

   OriginalPaper 13 December 2006 Pages: 573 - 587

10. Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone

    • J. Pratap
    • J. B. Lian
    • G. S. Stein

    OriginalPaper 13 December 2006 Pages: 589 - 600

11. The central role of osteoblasts in the metastasis of prostate cancer

    • Michel B. Choueiri
    • Shi-Ming Tu
    • Sue-Hwa Lin

    OriginalPaper 09 December 2006 Pages: 601 - 609

12. CCL2 (Monocyte Chemoattractant Protein-1) in cancer bone metastases

    • Matt J. Craig
    • Robert D. Loberg

    OriginalPaper 12 December 2006 Pages: 611 - 619

13. Molecular interactions between breast cancer cells and the bone microenvironment drive skeletal metastases

    • V.A. Siclari
    • T.A. Guise
    • J.M. Chirgwin

    OriginalPaper 13 December 2006 Pages: 621 - 633

14. Breast cancer bone metastasis and current small therapeutics

    • Muzaffer Cicek
    • Merry Jo Oursler

    OriginalPaper 12 December 2006 Pages: 635 - 644

15. Mechanisms of invasion and metastasis in human neuroblastoma

    • Tasnim Ara
    • Yves A. DeClerck

    OriginalPaper 12 December 2006 Pages: 645 - 657

16. Biochemical approach to the detection and monitoring of metastatic bone disease: What do we know and what questions need answers?

    • László B. Tankó
    • Morten A. Karsdal
    • Diana J. Leeming

    OriginalPaper 09 December 2006 Pages: 659 - 668

17. Targeted and systemic radiotherapy in the treatment of bone metastasis

    • Alexander Lin
    • Michael E. Ray

    OriginalPaper 09 December 2006 Pages: 669 - 675

18. Lymphatic endothelial cells, tumor lymphangiogenesis and metastasis: New insights into intratumoral and peritumoral lymphatics

    • Rui-Cheng Ji

    NON-THEMATIC REVIEW 12 December 2006 Pages: 677 - 694

19. The signaling mechanism of ROS in tumor progression

    • Wen-Sheng Wu

    NON-THEMATIC REVIEW 12 December 2006 Pages: 695 - 705

20. Anti-angiogenic therapy for osteosarcoma

    • Gerald M. Y. Quan
    • Peter F. M. Choong

    NON-THEMATIC REVIEW 12 December 2006 Pages: 707 - 713