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Next generation tissue engineering of orthopedic soft tissue-to-bone interfaces

  • Biomaterials for 3D Cell Biology Prospective Article
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Abstract

Soft tissue-to-bone interfaces are complex structures that consist of gradients of extracellular matrix materials, cell phenotypes, and biochemical signals. These interfaces, called entheses for ligaments, tendons, and the meniscus, are crucial to joint function, transferring mechanical loads and stabilizing orthopedic joints. When injuries occur to connected soft tissue, the enthesis must be re-established to restore function, but due to structural complexity, repair has proven challenging. Tissue engineering offers a promising solution for regenerating these tissues. This prospective review discusses methodologies for tissue engineering the enthesis, outlined in three key design inputs: materials processing methods, cellular contributions, and biochemical factors.

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Acknowledgments

The authors acknowledge support from the National Center for Advancing Translational Sciences (NCATS) grant TL1TR000459 of the Clinical and Translational Science Center at Weill Cornell Medical College, and A.J.B. acknowledges a pre-doctoral fellowship award (F31AR070009) from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health (NIH). The authors would like to thank Leanne Iannucci, Benjamin Cohen, and Jongkil Kim for critical reading of the manuscript and Mary Lou Norman for preparing histological sections.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, Cornell University, Ithaca, New York, USA

    Alexander J. Boys & Lara A. Estroff

  2. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA

    Mary Clare McCorry

  3. Orthopedic Surgery, Hospital for Special Surgery, New York, New York, USA

    Scott Rodeo

  4. Sports Medicine and Shoulder Service, Hospital for Special Surgery, New York, New York, USA

    Scott Rodeo

  5. Tissue Engineering, Regeneration, and Repair Program, Hospital for Special Surgery, New York, New York, USA

    Scott Rodeo

  6. Orthopedic Surgery, Weill Medical College of Cornell University, Cornell University, New York, New York, USA

    Scott Rodeo

  7. New York Giants, East Rutherford, New Jersey, USA

    Scott Rodeo

  8. Department of Orthopedic Surgery, Hospital for Special Surgery, New York, New York, USA

    Scott Rodeo

  9. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA

    Lawrence J. Bonassar

  10. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, USA

    Lawrence J. Bonassar

  11. Kavli Institute at Cornell, Cornell University, Ithaca, New York, USA

    Lara A. Estroff

Authors
  1. Alexander J. Boys
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  2. Mary Clare McCorry
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  3. Scott Rodeo
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  4. Lawrence J. Bonassar
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  5. Lara A. Estroff
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Corresponding authors

Correspondence to Lawrence J. Bonassar or Lara A. Estroff.

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Authors contributed equally to the manuscript.

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Boys, A.J., McCorry, M.C., Rodeo, S. et al. Next generation tissue engineering of orthopedic soft tissue-to-bone interfaces. MRS Communications 7, 289–308 (2017). https://doi.org/10.1557/mrc.2017.91

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  • DOI: https://doi.org/10.1557/mrc.2017.91

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