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Herpes Simplex Virus

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Congenital and Perinatal Infections

Part of the book series: Infectious Disease ((ID))

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Abstract

Herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) are two of the eight known viruses that make up the human herpesvirus family. As with all herpesviruses, they are large, enveloped virions with an icosahedral nucleocapsid consisting of 162 capsomeres arranged around a linear, double-stranded deoxyribonucleic acid (DNA) core. The DNAs of HSV-1 and HSV-2 are largely colinear, and considerable homology exists between the HSV-1 and HSV-2 genomes. These homologous sequences are distributed over the entire genomic map, and most of the polypeptides specified by one viral type are antigenically related to polypeptides of the other viral type. This results in considerable cross-reactivity between the HSV-1 and HSV-2 glycoproteins, although unique antigenic determinants exist for each virus.

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Authors and Affiliations

  1. Division of Infectious Diseases, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL

    David W. Kimberlin MD

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  1. David W. Kimberlin MD
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Editors and Affiliations

  1. Division of Infectious Diseases, Department of Pediatrics, University of Alabama School of Medicine, Birmingham, AL

    Cecelia Hutto MD

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© 2006 Humana Press Inc., Totowa, NJ

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Kimberlin, D.W. (2006). Herpes Simplex Virus. In: Hutto, C. (eds) Congenital and Perinatal Infections. Infectious Disease. Humana Press. https://doi.org/10.1385/1-59259-965-6:063

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  • DOI: https://doi.org/10.1385/1-59259-965-6:063

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-297-1

  • Online ISBN: 978-1-59259-965-3

  • eBook Packages: MedicineMedicine (R0)

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