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Active force maintains the stability of a contractile ring

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Abstract.

We investigate a system of sufficiently dense polar actin filaments considered rigid and cross-linked by dimer myosin II protein within the contractile ring. The Langevin dynamics of this system is cast in a functional integral formalism and then transformed into density variables. Using the dynamical Random Phase Approximation (RPA) along with the a one-dimensional Langevin dynamics simulation (LDS), we investigate the structural integrity of the actin bundle network. The active force and the networking force reveal a non-trivial diffusive behaviour of the filaments within the ring. We conclude on when the active and networking forces lead to the contractile ring breaking down. The non-equilibrium active force is predominantly responsible for the prevention of the gaps in the ring.

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Authors and Affiliations

  1. Institute of Theoretical Physics, Department of Physics, Stellenbosch University, 7600, Stellenbosch, South Africa

    Stanard Mebwe Pachong & Kristian K. Müller-Nedebock

  2. National Institute for Theoretical Physics, 7600, Stellenbosch, South Africa

    Kristian K. Müller-Nedebock

Authors
  1. Stanard Mebwe Pachong
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  2. Kristian K. Müller-Nedebock
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Correspondence to Stanard Mebwe Pachong.

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Pachong, S.M., Müller-Nedebock, K.K. Active force maintains the stability of a contractile ring. Eur. Phys. J. E 40, 91 (2017). https://doi.org/10.1140/epje/i2017-11581-9

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