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Preparation and Physicochemical Properties of the Ecdysteroid-Containing Nanodispersions Based on the Triterpenoids from Birch Bark

  • POLYMER, BIOORGANIC, AND HYBRID NANOMATERIALS
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Abstract

The physicochemical parameters of spherical amorphous nanoparticles (SANPs), consisting of a mixture of triterpenoids of birch bark (MTB) with 20-hydroxyecdysone (20E), are studied. The nanoparticles are obtained by injection and investigated by electron microscopy, dynamic light scattering, and UV spectroscopy. In the studied series of concentrations of 20E from 5 to 20 wt %, in relation to the mass of the MTB, the optimal concentration is 20E 10 wt %; at this concentration, the most stable nanodispersions are formed in water, 20E is fully included in the SANPs, their average size is 193.1 nm, they are characterized by a narrow polydispersity interval, and they have the greatest absolute value of the ζ-potential. Ecdysteroid-containing SANPs of this composition can be recommended for use in medicine as prolonged forms of ecdysteroids as radioprotective and other pharmacological agents.

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Funding

The research was carried out at the Institute of Biology, Komi Scientific Center, Ural Branch, Russian Academy of Sciences (state registration no. AAAA-A17-117121270025-1) and the Joint Russian-Vietnamese Tropical Research and Technological Center “Biologically active substances of tropical plants and microorganisms” (Ekolan M-4.1).

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Authors and Affiliations

  1. Institute of Biology, Komi Science Center, Ural Branch, Russian Academy of Sciences, 167982, Syktyvkar, Russia

    V. V. Volodin & S. O. Volodina

  2. Joint Russian-Vietnamese Tropical Research and Technological Center, Nguen Van Huen, Ngia Do, Hanoi, Vietnam

    Nguyen Hong Quang

  3. Lomonosov Institute of Fine Chemical Technologies, Russian Technological University (MIREA), 119571, Moscow, Russia

    A. P. Kaplun

Authors
  1. V. V. Volodin
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  2. Nguyen Hong Quang
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  3. A. P. Kaplun
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  4. S. O. Volodina
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Correspondence to V. V. Volodin.

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Volodin, V.V., Quang, N.H., Kaplun, A.P. et al. Preparation and Physicochemical Properties of the Ecdysteroid-Containing Nanodispersions Based on the Triterpenoids from Birch Bark. Nanotechnol Russia 15, 37–44 (2020). https://doi.org/10.1134/S1995078020010073

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  • DOI: https://doi.org/10.1134/S1995078020010073

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