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Synthesis and Biological Activity of 4,5,6,7-Tetrahydro-2H-indazole Derivatives

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Abstract

Novel 4,5,6,7-tetrahydro-2H-indazole derivatives were obtained via the reaction of N1,N3,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with hydrazine hydrate. The reaction of 4-oxocyclo-hexane-1,3-dicarboxamides with phenylhydrazine led to the formation of hydrazones instead of indazoles. The synthesized compounds were tested for antimicrobial, analgesic and anti-inflammatory activities

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, ul. Polevaya 2, Perm, 614990, Russia

    V. L. Gein, N. V. Nosova, E. B. Levandovskaya, V. V. Novikova & I. P. Rudakova

  2. St. Petersburg State University, St. Petersburg, Russia

    A. N. Yankin

Authors
  1. V. L. Gein
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  2. A. N. Yankin
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  3. N. V. Nosova
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  4. E. B. Levandovskaya
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  5. V. V. Novikova
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  6. I. P. Rudakova
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Corresponding author

Correspondence to V. L. Gein.

Additional information

Russian Text © The Author(s), 2019, published in Zhurnal Obshchei Khimii, 2019, Vol. 89, No. 6, pp. 954–962.

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The authors declare no conflict of interest.

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Gein, V.L., Yankin, A.N., Nosova, N.V. et al. Synthesis and Biological Activity of 4,5,6,7-Tetrahydro-2H-indazole Derivatives. Russ J Gen Chem 89, 1169–1176 (2019). https://doi.org/10.1134/S1070363219060112

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  • DOI: https://doi.org/10.1134/S1070363219060112

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