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Protective effect of hesperidin in Poloxamer-407 induced hyperlipidemic experimental rats

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Abstract

Hyperlipidemia is one of the leading causes of, atherosclerosis, and cardiovascular disease. In this study, we evaluated the protective role of hesperidin (HES) against lipidemic stress in a hyperlipidemic model of rats. We developed a hyperlipidemic model of the rat through an i.p dose of poloxamer-407, 0.5 g/kg body weight for 3 alternative days in a week for 30 days and rats were supplemented with HES orally (100 mg/kg body weight) once daily. Bodyweight, fasting glucose, insulin, HOMA-IR index, triglyceride, cholesterol, ROS, FRAP, GSH, PMRS, AGE, MDA, PCO, AOPP, PON-1, TNF-α and IL-6, SGPT and SGOT were estimated in blood and plasma, and histopathology was done in liver tissue. Our data show that oxidative stress, inflammatory markers were increased in the P-407 treated group. Liver tissue histology also changes in the hyperlipidemic groups of rats.HES supplementation protects against P-407 induced alterations and maintains the redox homeostasis. Our results provide evidence that HES protects against lipidemic stress and redox imbalance induced by P-407 in rats.

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Data availability statement

The information that helps the finding of this study is accessible from the corresponding author upon reasonable request.

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Funding

This work was supported by a research grant to SIR from SERB-DST, Govt of India (EMR/2016/006470). The Department of Biochemistry is supported by the FIST grant of DST, New Delhi, India.

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  1. Department of Biochemistry, University of Allahabad, Allahabad, 211002, India

    Raushan Kumar, Farhan Akhtar & Syed Ibrahim Rizvi

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  1. Raushan Kumar
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  2. Farhan Akhtar
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  3. Syed Ibrahim Rizvi
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RK Performing experiments, compiling results, a draft of the manuscript. FA Performing experiments. SIR Conception of the study, analysis of results, and manuscript preparation.

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Correspondence to Syed Ibrahim Rizvi.

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Kumar, R., Akhtar, F. & Rizvi, S.I. Protective effect of hesperidin in Poloxamer-407 induced hyperlipidemic experimental rats. BIOLOGIA FUTURA 72, 201–210 (2021). https://doi.org/10.1007/s42977-020-00053-1

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