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Do Postoperative Pain Management Techniques Influence Postoperative Delirium?

  • Perioperative Delirium (JM Leung, Section Editor)
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Abstract

Postoperative delirium (POD) is a common postoperative complication in older patients and may increase morbidity and mortality. The etiology of POD is multifactorial and suggested to be the result of interactions between patient vulnerability (predisposing factors) and exposure to precipitating factors. Poorly controlled postoperative pain has been identified as a precipitating risk factor for POD. However, effective pain management strategies to reduce incidence of POD are still far from being elucidated. Postoperative pain management techniques in older patients have changed substantially in recent years; for example, peripheral nerve blocks and multimodal analgesia have become common adjunctive techniques. It is unclear; however, whether these pain control management techniques can change the incidence of POD. In this review, we will focus on the English-language literature published last 30 years investigating the association between pain management strategies and incidence of POD. We will review opioid analgesics which are the most commonly used postoperative pain medications for major surgery. In addition, we will highlight pain control techniques including intravenous patient-controlled analgesia, epidural analgesia, peripheral nerve blocks, multimodal analgesia, and structured pain management protocols in multi-component delirium intervention. Furthermore, pain control in cognitively impaired patients will be reviewed.

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References

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  1. O’Keeffe ST, Ni Chonchubhair A. Postoperative delirium in the elderly. Br J Anaesth. 1994;73(5):673–87.

    Article  PubMed  Google Scholar 

  2. Witlox J, et al. Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: a meta-analysis. JAMA. 2010;304(4):443–51.

    Article  CAS  PubMed  Google Scholar 

  3. Inouye SK, et al. Does delirium contribute to poor hospital outcomes? A three-site epidemiologic study. J Gen Intern Med. 1998;13(4):234–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Bellelli G, et al. Duration of postoperative delirium is an independent predictor of 6-month mortality in older adults after hip fracture. J Am Geriatr Soc. 2014;62(7):1335–40.

    Article  PubMed  Google Scholar 

  5. Zywiel MG, et al. The influence of anesthesia and pain management on cognitive dysfunction after joint arthroplasty: a systematic review. Clin Orthop Relat Res. 2014;472(5):1453–66.

    Article  PubMed  Google Scholar 

  6. Inouye SK. Delirium in older persons. N Engl J Med. 2006;354(11):1157–65.

    Article  CAS  PubMed  Google Scholar 

  7. Inouye SK, Charpentier PA. Precipitating factors for delirium in hospitalized elderly persons. Predictive model and interrelationship with baseline vulnerability. JAMA. 1996;275(11):852–7.

    Article  CAS  PubMed  Google Scholar 

  8. Benoit AG, et al. Risk factors and prevalence of perioperative cognitive dysfunction in abdominal aneurysm patients. J Vasc Surg. 2005;42(5):884–90.

    Article  PubMed  Google Scholar 

  9. Brouquet A, et al. Impaired mobility, ASA status and administration of tramadol are risk factors for postoperative delirium in patients aged 75 years or more after major abdominal surgery. Ann Surg. 2010;251(4):759–65.

    Article  PubMed  Google Scholar 

  10. Katznelson R, et al. Delirium following vascular surgery: increased incidence with preoperative beta-blocker administration. Can J Anaesth. 2009;56(11):793–801.

    Article  PubMed  Google Scholar 

  11. Miyazaki S, et al. Risk factors of stroke and delirium after off-pump coronary artery bypass surgery. Interact CardioVasc Thorac Surg. 2011;12(3):379–83.

    Article  PubMed  Google Scholar 

  12. McDaniel M, Brudney C. Postoperative delirium: etiology and management. Curr Opin Crit Care. 2012;18(4):372–6.

    Article  PubMed  Google Scholar 

  13. Roche V. Southwestern internal medicine conference. Etiology and management of delirium. Am J Med Sci. 2003;325(1):20–30.

    Article  PubMed  Google Scholar 

  14. Han L, et al. Use of medications with anticholinergic effect predicts clinical severity of delirium symptoms in older medical inpatients. Arch Intern Med. 2001;161(8):1099–105.

    Article  CAS  PubMed  Google Scholar 

  15. MacLullich AM, et al. Cerebrospinal fluid interleukin-8 levels are higher in people with hip fracture with perioperative delirium than in controls. J Am Geriatr Soc. 2011;59(6):1151–3.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Cerejeira J, et al. The cholinergic system and inflammation: common pathways in delirium pathophysiology. J Am Geriatr Soc. 2012;60(4):669–75.

    Article  PubMed  Google Scholar 

  17. Wood PB, et al. Fibromyalgia patients show an abnormal dopamine response to pain. Eur J Neurosci. 2007;25(12):3576–82.

    Article  PubMed  Google Scholar 

  18. Lynch EP, et al. The impact of postoperative pain on the development of postoperative delirium. Anesth Analg. 1998;86(4):781–5.

    Article  CAS  PubMed  Google Scholar 

  19. Vaurio LE, et al. Postoperative delirium: the importance of pain and pain management. Anesth Analg. 2006;102(4):1267–73.

    Article  PubMed  Google Scholar 

  20. • Nie H, et al. Pain and cognitive dysfunction are the risk factors of delirium in elderly hip fracture Chinese patients. Arch Gerontol Geriatr. 2012;54(2):e172–4. Pain intensity and preoperative cognitve dysfunction are the risk factors of postoperative delirium in elderly Chinese hip fracture patients.

  21. Morrison RS, et al. Relationship between pain and opioid analgesics on the development of delirium following hip fracture. J Gerontol A Biol Sci Med Sci. 2003;58(1):76–81.

    Article  PubMed  Google Scholar 

  22. Morrison RS, et al. The impact of post-operative pain on outcomes following hip fracture. Pain. 2003;103(3):303–11.

    Article  PubMed  Google Scholar 

  23. Robertson BD, Robertson TJ. Postoperative delirium after hip fracture. J Bone Joint Surg Am. 2006;88(9):2060–8.

    PubMed  Google Scholar 

  24. Owen JA, et al. Age-related morphine kinetics. Clin Pharmacol Ther. 1983;34(3):364–8.

    Article  CAS  PubMed  Google Scholar 

  25. Aubrun F, Mazoit JX, Riou B. Postoperative intravenous morphine titration. Br J Anaesth. 2012;108(2):193–201.

    Article  CAS  PubMed  Google Scholar 

  26. Adunsky A, et al. Meperidine analgesia and delirium in aged hip fracture patients. Arch Gerontol Geriatr. 2002;35(3):253–9.

    Article  CAS  PubMed  Google Scholar 

  27. Eisendrath SJ, et al. Meperidine-induced delirium. Am J Psychiatry. 1987;144(8):1062–5.

    Article  CAS  PubMed  Google Scholar 

  28. Marcantonio ER, et al. The relationship of postoperative delirium with psychoactive medications. JAMA. 1994;272(19):1518–22.

    Article  CAS  PubMed  Google Scholar 

  29. Stone PA, Macintyre PE, Jarvis DA. Norpethidine toxicity and patient controlled analgesia. Br J Anaesth. 1993;71(5):738–40.

    Article  CAS  PubMed  Google Scholar 

  30. Agrawal A, Diwan SK, Mahajan R. Severe delirium following single dose of tramadol. Indian J Med Sci. 2009;63(2):80–1.

    Article  PubMed  Google Scholar 

  31. Crane JH, Suda KJ. Oxycodone induced delirium and agitation in an elderly patient following total right knee arthroplasty. Int J Clin Pharm. 2011;33(5):733–6.

    Article  CAS  PubMed  Google Scholar 

  32. Kunig G, et al. Unrecognised long-lasting tramadol-induced delirium in two elderly patients. A case report. Pharmacopsychiatry. 2006;39(5):194–9.

    Article  CAS  PubMed  Google Scholar 

  33. •• Nandi S, et al. Pharmacologic risk factors for post-operative delirium in total joint arthroplasty patients: a case-control study. J Arthroplasty 2014;29(2):268–71. The use of hydromorphone and morphine decreases the risk of delirium and other opiate pain medications including tramadol and oxycodone do not affect the delirium risk in total joint arthroplasty patients.

  34. Egbert AM, et al. Randomized trial of postoperative patient-controlled analgesia versus intramuscular narcotics in frail elderly men. Arch Intern Med. 1990;150(9):1897–903.

    Article  CAS  PubMed  Google Scholar 

  35. Keita H, et al. Comparison between patient-controlled analgesia and subcutaneous morphine in elderly patients after total hip replacement. Br J Anaesth. 2003;90(1):53–7.

    Article  CAS  PubMed  Google Scholar 

  36. Aubrun F, Marmion F. The elderly patient and postoperative pain treatment. Best Pract Res Clin Anaesthesiol. 2007;21(1):109–27.

    Article  PubMed  Google Scholar 

  37. Block BM, et al. Efficacy of postoperative epidural analgesia: a meta-analysis. JAMA. 2003;290(18):2455–63.

    Article  CAS  PubMed  Google Scholar 

  38. Liu S, Carpenter RL, Neal JM. Epidural anesthesia and analgesia. Their role in postoperative outcome. Anesthesiology. 1995;82(6):1474–506.

    Article  CAS  PubMed  Google Scholar 

  39. Flisberg P, et al. Pain relief and safety after major surgery. A prospective study of epidural and intravenous analgesia in 2696 patients. Acta Anaesthesiol Scand. 2003;47(4):457–65.

    Article  CAS  PubMed  Google Scholar 

  40. Eriksson-Mjoberg M, et al. Extradural morphine gives better pain relief than patient-controlled i.v. morphine after hysterectomy. Br J Anaesth. 1997;78(1):10–6.

    Article  CAS  PubMed  Google Scholar 

  41. Williams-Russo P, et al. Post-operative delirium: predictors and prognosis in elderly orthopedic patients. J Am Geriatr Soc. 1992;40(8):759–67.

    Article  CAS  PubMed  Google Scholar 

  42. Mann C, et al. Comparison of intravenous or epidural patient-controlled analgesia in the elderly after major abdominal surgery. Anesthesiology. 2000;92(2):433–41.

    Article  CAS  PubMed  Google Scholar 

  43. Beaussier M, et al. Postoperative analgesia and recovery course after major colorectal surgery in elderly patients: a randomized comparison between intrathecal morphine and intravenous PCA morphine. Reg Anesth Pain Med. 2006;31(6):531–8.

    CAS  PubMed  Google Scholar 

  44. • Kinjo S, et al. Does using a femoral nerve block for total knee replacement decrease postoperative delirium? BMC Anesthesiol. 2012;12:4. Continous femoral nerve block reduces the incidence of postoperative delirium compared with IV PCA.

  45. Marcantonio ER, et al. Delirium is independently associated with poor functional recovery after hip fracture. J Am Geriatr Soc. 2000;48(6):618–24.

    Article  CAS  PubMed  Google Scholar 

  46. Duppils GS, Wikblad K. Cognitive function and health-related quality of life after delirium in connection with hip surgery. A six-month follow-up. Orthop Nurs. 2004;23(3):195–203.

    Article  PubMed  Google Scholar 

  47. Rashiq S, et al. Efficacy of supplemental peripheral nerve blockade for hip fracture surgery: multiple treatment comparison. Can J Anaesth. 2013;60(3):230–43.

    Article  PubMed  Google Scholar 

  48. Mouzopoulos G, et al. Fascia iliaca block prophylaxis for hip fracture patients at risk for delirium: a randomized placebo-controlled study. J Orthop Traumatol. 2009;10(3):127–33.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Marino J, et al. Continuous lumbar plexus block for postoperative pain control after total hip arthroplasty. A randomized controlled trial. J Bone Joint Surg Am. 2009;91(1):29–37.

    Article  PubMed  Google Scholar 

  50. Abou-Setta AM, et al. Comparative effectiveness of pain management interventions for hip fracture: a systematic review. Ann Intern Med. 2011;155(4):234–45.

    Article  PubMed  Google Scholar 

  51. Rosero EB, Joshi GP. Preemptive, preventive, multimodal analgesia: what do they really mean? Plast Reconstr Surg. 2014;134(4 Suppl 2):85S–93S.

    Article  CAS  PubMed  Google Scholar 

  52. Halaszynski TM. Pain management in the elderly and cognitively impaired patient: the role of regional anesthesia and analgesia. Curr Opin Anaesthesiol. 2009;22(5):594–9.

    Article  PubMed  Google Scholar 

  53. Buvanendran A, Kroin JS. Multimodal analgesia for controlling acute postoperative pain. Curr Opin Anaesthesiol. 2009;22(5):588–93.

    Article  PubMed  Google Scholar 

  54. Costantini R, et al. Controlling pain in the post-operative setting. Int J Clin Pharmacol Ther. 2011;49(2):116–27.

    Article  CAS  PubMed  Google Scholar 

  55. Kong VK, Irwin MG. Gabapentin: a multimodal perioperative drug? Br J Anaesth. 2007;99(6):775–86.

    Article  CAS  PubMed  Google Scholar 

  56. •• Krenk, L, et al. Delirium after fast-track hip and knee arthroplasty. Br J Anaesth. 2012;108(4):607–11. A fast-track set-up with standardized multimodal opioid-sparing pain management decreases the incidence of postoperative delirium to zero in elderly patients undergoing elective total hip arthroplasty and total knee arthroplasty.

  57. Milisen K, et al. A nurse-led interdisciplinary intervention program for delirium in elderly hip-fracture patients. J Am Geriatr Soc. 2001;49(5):523–32.

    Article  CAS  PubMed  Google Scholar 

  58. Ogilvie-Harris DJ, Botsford DJ, Hawker RW. Elderly patients with hip fractures: improved outcome with the use of care maps with high-quality medical and nursing protocols. J Orthop Trauma. 1993;7(5):428–37.

    Article  CAS  PubMed  Google Scholar 

  59. Leung JM, et al. Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients. Neurology. 2006;67(7):1251–3.

    Article  CAS  PubMed  Google Scholar 

  60. Dighe K, et al. Perioperative gabapentin and delirium following total knee arthroplasty: a post hoc analysis of a double-blind randomized placebo-controlled trial. Can J Anaesth. 2014. doi:https://doi.org/10.1007/s12630-014-0235-5.

  61. Fine J, Finestone SC. Sensory disturbances following ketamine anesthesia: recurrent hallucinations. Anesth Analg. 1973;52(3):428–30.

    Article  CAS  PubMed  Google Scholar 

  62. Lilburn JK, et al. Ketamine sequelae. Evaluation of the ability of various premedicants to attenuate its psychic actions. Anaesthesia. 1978;33(4):307–11.

    Article  CAS  PubMed  Google Scholar 

  63. Bell RF, et al. Perioperative ketamine for acute postoperative pain. Cochrane Database Syst Rev. 2006;(1):CD004603. doi:https://doi.org/10.1002/14651858.CD004603.pub2.

  64. Hudetz JA, et al. Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2009;23(5):651–7.

    Article  CAS  PubMed  Google Scholar 

  65. Hudetz JA, et al. Ketamine attenuates post-operative cognitive dysfunction after cardiac surgery. Acta Anaesthesiol Scand. 2009;53(7):864–72.

    Article  CAS  PubMed  Google Scholar 

  66. Bartoc C, et al. A randomized, double-blind, placebo-controlled study assessing the anti-inflammatory effects of ketamine in cardiac surgical patients. J Cardiothorac Vasc Anesth. 2006;20(2):217–22.

    Article  CAS  PubMed  Google Scholar 

  67. Reeves M, et al. Adding ketamine to morphine for patient-controlled analgesia after major abdominal surgery: a double-blinded, randomized controlled trial. Anesth Analg. 2001;93(1):116–20.

    Article  CAS  PubMed  Google Scholar 

  68. Patel J, et al. The effect of a multicomponent multidisciplinary bundle of interventions on sleep and delirium in medical and surgical intensive care patients. Anaesthesia. 2014;69(6):540–9.

    Article  CAS  PubMed  Google Scholar 

  69. Pitkala KH, et al. Multicomponent geriatric intervention for elderly inpatients with delirium: effects on costs and health-related quality of life. J Gerontol A Biol Sci Med Sci. 2008;63(1):56–61.

    Article  PubMed  Google Scholar 

  70. Zhang H, et al. Strategies for prevention of postoperative delirium: a systematic review and meta-analysis of randomized trials. Crit Care. 2013;17(2):R47.

    Article  PubMed  PubMed Central  Google Scholar 

  71. Marcantonio ER, et al. Reducing delirium after hip fracture: a randomized trial. J Am Geriatr Soc. 2001;49(5):516–22.

    Article  CAS  PubMed  Google Scholar 

  72. Pedersen SJ, et al. A comprehensive hip fracture program reduces complication rates and mortality. J Am Geriatr Soc. 2008;56(10):1831–8.

    Article  PubMed  Google Scholar 

  73. Adunsky A, et al. Exposure to opioid analgesia in cognitively impaired and delirious elderly hip fracture patients. Arch Gerontol Geriatr. 2002;35(3):245–51.

    Article  PubMed  Google Scholar 

  74. Leung JM, et al. Does preoperative risk for delirium moderate the effects of postoperative pain and opiate use on postoperative delirium? Am J Geriatr Psychiatry. 2013;21(10):946–56.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Pesonen A, et al. Evaluation of easily applicable pain measurement tools for the assessment of pain in demented patients. Acta Anaesthesiol Scand. 2009;53(5):657–64.

    Article  CAS  PubMed  Google Scholar 

  76. Clark ME, Gironda RJ, Young RW. Development and validation of the pain outcomes Questionnaire-VA. J Rehabil Res Dev. 2003;40(5):381–95.

    Article  PubMed  Google Scholar 

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Correspondence to Sakura Kinjo.

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This article is part of the Topical Collection on Perioperative Delirium.

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Zhang, X., Kinjo, S. Do Postoperative Pain Management Techniques Influence Postoperative Delirium?. Curr Anesthesiol Rep 5, 10–16 (2015). https://doi.org/10.1007/s40140-014-0089-y

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