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XPA gene rs1800975 single nucleotide polymorphism and lung cancer risk: a meta-analysis

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Tumor Biology

Abstract

No clear consensus has been reached on the XPA gene rs1800975 polymorphism and lung cancer risk. We performed a meta-analysis in an effort to systematically explore the possible association. We conducted a computer retrieval of PubMed, Embase, Wanfang, China National Knowledge Infrastructure Platform, and VIP databases prior to November 2013. References of retrieved articles were also screened. The fixed- and the random-effects model were applied for dichotomous outcomes to combine the results of the individual studies. According to the inclusion criteria, 10 articles (11 studies) were finally included. In overall, statistical association could be found between rs1800975 polymorphism and lung cancer in recessive genetic model [AA vs. (AG + GG): P = 0.02, OR = 1.16, 95% CI 1.02–1.31, P heterogeneity = 0.14, fixed-effects model]. In the East Asians, significant association was found in allele comparison model (A vs. G: P = 0.03, OR = 1.13, 95% CI 1.01–1.26, P heterogeneity = 0.39, fixed-effects model), in recessive genetic model [AA vs. (AG + GG): P = 0.005, OR = 1.30, 95% CI 1.08–1.56, P heterogeneity = 0.58, fixed-effects model] and in the homozygote comparison (AA vs. GG: P = 0.02, OR = 1.30, 95% CI 1.04–1.63, P heterogeneity = 0.39, fixed-effects model). No evidence suggested that rs1800975 polymorphism might associate with lung cancer in other ethnicities. Stratification analysis performed by histologic types indicated that AA genotype might represent a risk factor for squamous cell carcinoma [AA vs. (AG + GG): P = 0.01, OR = 1.42, 95% CI 1.08–1.86, P heterogeneity = 0.27, fixed-effects model; AA vs. GG: P = 0.03, OR = 1.43, 95% CI 1.04–1.96, P heterogeneity = 0.21, fixed-effects model]. No association was observed in adenocarcinoma subgroup. Our study suggested that XPA rs1800975 polymorphism might associate with lung cancer risk in overall and in East Asians. This polymorphism might also associate with squamous cell carcinoma.

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Acknowledgments

This work was supported by the National Natural Science foundation of China (81201839 and 81101770), the Research Project of Shanghai Municipal Commission of Health and Family Planning (20124Y108), the Excellent Young Teachers Program of Shanghai Jiaotong University School of Medicine, and the Science and Technology Foundation of Shanghai Chest Hospital (YZ12-03).

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Authors and Affiliations

  1. Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiaotong University, 241 West Huaihai Road, Shanghai, 200030, People’s Republic of China

    Yuqing Lou, Rong Li, Yanwei Zhang, Runbo Zhong, Jun Pei, Liwen Xiong, Xueyan Zhang & Baohui Han

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  1. Yuqing Lou
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Correspondence to Xueyan Zhang or Baohui Han.

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Y. Lou and R. Li contributed equally to this work.

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Lou, Y., Li, R., Zhang, Y. et al. XPA gene rs1800975 single nucleotide polymorphism and lung cancer risk: a meta-analysis. Tumor Biol. 35, 6607–6617 (2014). https://doi.org/10.1007/s13277-014-1824-1

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