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A Neurovascular Perspective for Long-Term Changes After Brain Trauma

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Abstract

Traumatic brain injury (TBI) affects all age groups in a population and is an injury generating scientific interest not only as an acute event, but also as a complex brain disease with several underlying neurobehavioral and neuropathological characteristics. We review early and long-term alterations after juvenile and adult TBI with a focus on changes in the neurovascular unit, including neuronal interactions with glia and blood vessels at the blood–brain barrier (BBB). Post-traumatic changes in cerebral blood flow, BBB structures and function, as well as mechanistic pathways associated with brain aging and neurodegeneration are presented from clinical and experimental reports. Based on the literature, increased attention on BBB changes should be integrated in studies characterizing TBI outcome and may provide a meaningful therapeutic target to resolve detrimental post-traumatic dysfunction.

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Acknowledgements

We thank Dane Sorensen for the critical review of the manuscript and David Ajao for the tissue samples. This study was supported in part by the NIH R01HD061946, Pediatric Research Fund, the Swiss Science Foundation (FN 31003A-122166 and IZK0Z3-128973).

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  1. Department of Pediatrics, Loma Linda University School of Medicine, Coleman Pavilion, Room A1120, 11175 Campus Street, Loma Linda, CA, 92354, USA

    V. Pop & J. Badaut

  2. Department of Physiology, Loma Linda University School of Medicine, Coleman Pavilion, Room A1120, 11175 Campus Street, Loma Linda, CA, 92354, USA

    J. Badaut

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  1. V. Pop
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Correspondence to J. Badaut.

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Pop, V., Badaut, J. A Neurovascular Perspective for Long-Term Changes After Brain Trauma. Transl. Stroke Res. 2, 533–545 (2011). https://doi.org/10.1007/s12975-011-0126-9

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  • DOI: https://doi.org/10.1007/s12975-011-0126-9

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