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T(1;21;8)(p34;q22;q22): a novel variant of t(8;21) in acute myeloblastic leukemia with maturation

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Abstract

The complex variants of t(8;21) involving chromosomes 8 and 21 as well as another chromosome account for approximately 3% of acute myeloid leukemia patients. We report here a 30-year-old male patient with AML-M2. Fluorescence in situ hybridization analysis using dual-color fluorescence ETO and AML1 probes located at 8q22 and 21q22 respectively showed an AML1/ETO fusion signal on the derivative chromosome 8. Whole chromosome painting probes were used for chromosome 1, 8 and 21 and revealed a three-way translocation (1;21;8)(p34 ~ p35;q22;q22). Involvement of chromosome region 1p34 has never been reported earlier, although region 1p35 as a variant in AML with t(8;21) has been reported with an AML1/ETO fusion signal on the 1p35 rather than der(8). In conclusion, combining conventional karyotype, FISH or RT–PCR analyses are a rational strategy for the identification of the complex variants of t(8;21) translocation which could be critical events responsible for leukemogenesis.

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Authors and Affiliations

  1. Laboratoire de Cytogénétique et de Biologie de la Reproduction, Hôpital Farhat Hached, Avenue Ibn Eljazzar, 4000, Sousse, Tunisie

    Abir Gmidène, Rim Frikha, Hlima Sennana, Hatem Elghezal & Ali Saad

  2. Service d’Hématologie, CHU Hédi Chaker, Sfax, Tunisie

    Moez Elloumi

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  1. Abir Gmidène
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  2. Rim Frikha
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  3. Hlima Sennana
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  4. Hatem Elghezal
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  5. Moez Elloumi
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  6. Ali Saad
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Correspondence to Abir Gmidène.

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Gmidène, A., Frikha, R., Sennana, H. et al. T(1;21;8)(p34;q22;q22): a novel variant of t(8;21) in acute myeloblastic leukemia with maturation. Med Oncol 28 (Suppl 1), 509–512 (2011). https://doi.org/10.1007/s12032-010-9703-0

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  • DOI: https://doi.org/10.1007/s12032-010-9703-0

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