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Non-Lyme Tick-Borne Diseases: A Neurological Perspective

  • Infection (J Berger, Section Editor)
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Abstract

Tick-borne diseases are prevalent throughout the world and present a diagnostic challenge owing to their nonspecific clinical symptoms. Many tick-borne diseases involve the central and peripheral nervous systems. Early diagnosis or at least suspicion of a tick-borne cause is necessary to institute early empiric treatment. After a brief review of tick biology, we present the most common tick-borne diseases. A brief discussion of epidemiology, the transmission route, and pathogenesis is followed by a discussion of the clinical manifestations, diagnosis and treatment options when available. The review emphasizes the infectious causes with a significant neurological manifestation.

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References

Papers of particular interest, published recently, have been highlighted: • Of importance

  1. Vannier E, Gewurz BE, Krause PJ. Human babesiosis. Infect Dis Clin North Am. 2008;22(3):469–88.

    Article  PubMed  Google Scholar 

  2. Emmons RW. Ecology of Colorado tick fever. Annu Rev Microbiol. 1988;42:49–64.

    Article  PubMed  CAS  Google Scholar 

  3. Centers for Disease Control and Prevention. Tularemia. http://www.cdc.gov/tularemia/index.html (2011). Accessed 15 Jul 2013.

  4. Sjostedt A. Tularemia: history, epidemiology, pathogen physiology, and clinical manifestations. Ann N Y Acad Sci. 2007;1105:1–29.

    Article  PubMed  Google Scholar 

  5. Nigrovic LE, Wingerter SL. Tularemia. Infect Dis Clin North Am. 2008;22(3):489–504.

    Article  PubMed  Google Scholar 

  6. Keim P, Johansson A, Wagner DM. Molecular epidemiology, evolution, and ecology of Francisella. Ann N Y Acad Sci. 2007;1105:30–66.

    Article  PubMed  CAS  Google Scholar 

  7. Morner T. The ecology of tularaemia. Rev Sci Tech. 1992;11(4):1123–30.

    PubMed  CAS  Google Scholar 

  8. Feldman KA, Enscore RE, Lathrop SL, Matyas BT, McGuill M, Schriefer ME, et al. An outbreak of primary pneumonic tularemia on Martha's Vineyard. New Engl J Med. 2001;345(22):1601–6.

    Article  PubMed  CAS  Google Scholar 

  9. Centers for Disease Control and Prevention. Tularemia associated with a hamster bite--Colorado, 2004. MMWR Morb Mortal Wkly Rep. 2005;53(51):1202–3.

  10. Capellan J, Fong IW. Tularemia from a cat bite: case report and review of feline-associated tularemia. Clin Infect Dis. 1993;16(4):472–5.

    Article  PubMed  CAS  Google Scholar 

  11. Liles WC, Burger RJ. Tularemia from domestic cats. West J Med. 1993;158(6):619–22.

    PubMed  CAS  Google Scholar 

  12. LeDoux MS. Tularemia presenting with ataxia. Clin Infect Dis. 2000;30(1):211–2.

    Article  PubMed  CAS  Google Scholar 

  13. van de Beek D, Steckelberg JM, Marshall WF, Kijpittayarit S, Wijdicks EF. Tularemia with brain abscesses. Neurology. 2007;68(7):531.

    Article  PubMed  Google Scholar 

  14. Ylipalosaari P, Ala-Kokko TI, Tuominen H, Syrjala H. Guillain–Barré syndrome and ulceroglandular tularemia. Infection. 2013;41(4):881–3.

    Article  PubMed  CAS  Google Scholar 

  15. Evans ME, Gregory DW, Schaffner W, McGee ZA. Tularemia: a 30-year experience with 88 cases. Medicine. 1985;64(4):251–69.

    Article  PubMed  CAS  Google Scholar 

  16. Sanders CV, Hahn R. Analysis of 106 cases of tularemia. J La State Med Soc. 1968;120(9):391–3.

    PubMed  CAS  Google Scholar 

  17. Centers for Disease Control and Prevention. Tick-borne relapsing fever (TBRF). http://www.cdc.gov/relapsing-fever/ (2012). Accessed 15 Jul 2013.

  18. Dworkin MS, Schwan TG, Anderson Jr DE, Borchardt SM. Tick-borne relapsing fever. Infect Dis Clin North Am. 2008;22(3):449–68.

    Article  PubMed  Google Scholar 

  19. Schwan TG, Hinnebusch BJ. Bloodstream- versus tick-associated variants of a relapsing fever bacterium. Science. 1998;280(5371):1938–40.

    Article  PubMed  CAS  Google Scholar 

  20. Southern PM, Sanford JP. Relapsing fever: a clinical and microbiological review. Medicine. 1969;48:20.

    Article  Google Scholar 

  21. Alugupalli KR, Gerstein RM, Chen J, Szomolanyi-Tsuda E, Woodland RT, Leong JM. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol. 2003;170(7):3819–27.

    PubMed  CAS  Google Scholar 

  22. Goubau PF. Relapsing fevers. a review. Ann Soc Belg Med Trop. 1984;64(4):335–64.

    PubMed  CAS  Google Scholar 

  23. Dworkin MS, Anderson Jr DE, Schwan TG, Shoemaker PC, Banerjee SN, Kassen BO, et al. Tick-borne relapsing fever in the northwestern United States and southwestern Canada. Clin Infect Dis. 1998;26(1):122–31.

    Article  PubMed  CAS  Google Scholar 

  24. Mushatt DM. Neurological aspects of North American zoonoses. Infect Dis Clin North Am. 1991;5(3):703–31.

    PubMed  CAS  Google Scholar 

  25. Cadavid D, Barbour AG. Neuroborreliosis during relapsing fever: review of the clinical manifestations, pathology, and treatment of infections in humans and experimental animals. Clin Infect Dis. 1998;26(1):151–64.

    Article  PubMed  CAS  Google Scholar 

  26. Halperin JJ. Abnormalities of the nervous system in Lyme disease: response to antimicrobial therapy. Rev Infect Dis. 1989;11 Suppl 6:S1499–504.

    Article  PubMed  Google Scholar 

  27. Kelly R. Cultivation of Borrelia hermsi. Science. 1971;173(3995):443–4.

    Article  PubMed  CAS  Google Scholar 

  28. Fukunaga M, Okada K, Nakao M, Konishi T, Sato Y. Phylogenetic analysis of Borrelia species based on flagellin gene sequences and its application for molecular typing of Lyme disease borreliae. Int J Syst Bacteriol. 1996;46(4):898–905.

    Article  PubMed  CAS  Google Scholar 

  29. Nassif X, Dupont B, Fleury J, Lapresle C. Ceftriaxone in relapsing fever. Lancet. 1988;2(8607):394.

    Article  PubMed  CAS  Google Scholar 

  30. Ricketts H. The study of “Rocky mountain spotted fever” (tick fever?) by means of animal inoculations. A preliminary communication. JAMA. 1906;47(1):3.

    Google Scholar 

  31. Scully RE. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 32–1997. A 43-year-old woman with rapidly changing pulmonary infiltrates and markedly increased intracranial pressure. New Engl. J Med. 1997;337(16):1149–56.

    Google Scholar 

  32. Centers for Disease Control and Prevention. Rocky mountain spotted fever (RMSF). http://www.cdc.gov/rmsf/stats/ (2013). Accessed 15 Jul 2013.

  33. Tamura A, Ohashi N, Urakami H, Miyamura S. Classification of Rickettsia tsutsugamushi in a new genus, Orientia gen. nov., as Orientia tsutsugamushi comb. nov. Int J Syst Bacteriol. 1995;45(3):589–91.

    Article  PubMed  CAS  Google Scholar 

  34. Chen LF, Sexton DJ. What's new in Rocky Mountain spotted fever? Infect Dis Clin North Am. 2008;22(3):415–32.

    Article  PubMed  Google Scholar 

  35. Martinez JJ, Cossart P. Early signaling events involved in the entry of Rickettsia conorii into mammalian cells. J Cell Sci. 2004;117(Pt 21):5097–106.

    Article  PubMed  CAS  Google Scholar 

  36. Walker DH. Targeting rickettsia. New Engl J Med. 2006;354(13):1418–20.

    Article  PubMed  CAS  Google Scholar 

  37. Heinzen RA, Grieshaber SS, Van Kirk LS, Devin CJ. Dynamics of actin-based movement by Rickettsia rickettsii in Vero cells. Infect Immun. 1999;67(8):4201–7.

    PubMed  CAS  Google Scholar 

  38. Heinzen RA. Rickettsial actin-based motility: behavior and involvement of cytoskeletal regulators. Ann N Y Acad Sci. 2003;990:535–47.

    Article  PubMed  CAS  Google Scholar 

  39. Wells GM, Woodward TE, Fiset P, Hornick RB. Rocky Mountain spotted fever caused by blood transfusion. JAMA. 1978;239(26):2763–5.

    Article  PubMed  CAS  Google Scholar 

  40. Sexton DJ, Gallis HA, McRae JR, Cate TR. Letter: possible needle-associated Rocky Mountain spotted fever. New Engl J Med. 1975;292(12):645.

    PubMed  CAS  Google Scholar 

  41. Horney LF, Walker DH. Meningoencephalitis as a major manifestation of Rocky Mountain spotted fever. South Med J. 1988;81(7):915–8.

    Article  PubMed  CAS  Google Scholar 

  42. Wei TY, Baumann RJ. Acute disseminated encephalomyelitis after Rocky Mountain spotted fever. Pediatr Neurol. 1999;21(1):503–5.

    Article  PubMed  CAS  Google Scholar 

  43. Walker DH, Gay RM, Valdes-Dapena M. The occurrence of eschars in Rocky Mountain spotted fever. J Am Acad Dermatol. 1981;4(5):571–6.

    Article  PubMed  CAS  Google Scholar 

  44. Bleck TP. Central nervous system involvement in rickettsial diseases. Neurol Clin. 1999;17(4):801–12.

    Article  PubMed  CAS  Google Scholar 

  45. Baganz MD, Dross PE, Reinhardt JA. Rocky Mountain spotted fever encephalitis: MR findings. AJNR Am J Neuroradiol. 1995;16(4 Suppl):919–22.

    PubMed  CAS  Google Scholar 

  46. • Crapp S, Harrar D, Strother M, Wushensky C, Pruthi S. Rocky mountain spotted fever: 'starry sky' appearance with diffusion-weighted imaging in a child. Pediatr Radiol. 2012;42(4):499–502. This is a case report of an interesting radiological feature associated with RMSF, with a discussion of radiological findings in the disease.

    Article  PubMed  Google Scholar 

  47. Rosenblum MJ, Masland RL, Harrell GT. Residual effects of rickettsial disease on the central nervous system; results of neurologic examinations and electroencephalograms following Rocky Mountain spotted fever. AMA Arch Intern Med. 1952;90(4):444–55.

    Article  PubMed  CAS  Google Scholar 

  48. Gorman RJ, Saxon S, Snead 3rd OC. Neurologic sequelae of Rocky Mountain spotted fever. Pediatrics. 1981;67(3):354–7.

    PubMed  CAS  Google Scholar 

  49. Bergeron JW, Braddom RL, Kaelin DL. Persisting impairment following Rocky Mountain spotted fever: a case report. Arch Phys Med Rehabil. 1997;78(11):1277–80.

    Article  PubMed  CAS  Google Scholar 

  50. Chapman AS, Bakken JS, Folk SM, Paddock CD, Bloch KC, Krusell A, et al. Diagnosis and management of tickborne rickettsial diseases: rocky mountain spotted fever, ehrlichioses, and anaplasmosis--United States: a practical guide for physicians and other health-care and public health professionals. MMWR Recomm Rep. 2006;55(RR-4):1–27.

    Google Scholar 

  51. Centers for Disease Control and Prevention. CDC - statistics - ehrlichiosis. http://www.cdc.gov/ehrlichiosis/stats/index.html (2012). Accessed15 Jul 2013.

  52. Salinas LJ, Greenfield RA, Little SE, Voskuhl GW. Tickborne infections in the southern United States. Am J Med Sci. 2010;340(3):194–201.

    Article  PubMed  Google Scholar 

  53. Zhang JZ, Popov VL, Gao S, Walker DH, Yu XJ. The developmental cycle of Ehrlichia chaffeensis in vertebrate cells. Cell Microbiol. 2007;9(3):610–8.

    Article  PubMed  CAS  Google Scholar 

  54. Ohashi N, Zhi N, Zhang Y, Rikihisa Y. Immunodominant major outer membrane proteins of Ehrlichia chaffeensis are encoded by a polymorphic multigene family. Infect Immun. 1998;66(1):132–9.

    PubMed  CAS  Google Scholar 

  55. Xiong Q, Lin M, Rikihisa Y. Cholesterol-dependent anaplasma phagocytophilum exploits the low-density lipoprotein uptake pathway. PLoS Pathog. 2009;5(3):e1000329.

    Article  PubMed  CAS  Google Scholar 

  56. Mattner J, Debord KL, Ismail N, Goff RD, Cantu 3rd C, Zhou D, et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature. 2005;434(7032):525–9.

    Article  PubMed  CAS  Google Scholar 

  57. Ismail N, Bloch KC, McBride JW. Human ehrlichiosis and anaplasmosis. Clin Lab Med. 2010;30(1):261–92.

    Article  PubMed  Google Scholar 

  58. Rikihisa Y. Ehrlichia subversion of host innate responses. Curr Opin Microbiol. 2006;9(1):95–101.

    Article  PubMed  CAS  Google Scholar 

  59. Zhang JZ, Sinha M, Luxon BA, Yu XJ. Survival strategy of obligately intracellular Ehrlichia chaffeensis: novel modulation of immune response and host cell cycles. Infect Immun. 2004;72(1):498–507.

    Article  PubMed  CAS  Google Scholar 

  60. Walker DH, Dumler JS. Human monocytic and granulocytic ehrlichioses. Discovery and diagnosis of emerging tick-borne infections and the critical role of the pathologist. Arch Pathol Lab Med. 1997;121(8):785–91.

    PubMed  CAS  Google Scholar 

  61. Sehdev AE, Dumler JS. Hepatic pathology in human monocytic ehrlichiosis. Ehrlichia chaffeensis infection. Am J Clin Pathol. 2003;119(6):859–65.

    Article  PubMed  Google Scholar 

  62. Marty AM, Dumler JS, Imes G, Brusman HP, Smrkovski LL, Frisman DM. Ehrlichiosis mimicking thrombotic thrombocytopenic purpura. Case report and pathological correlation. Hum Pathol. 1995;26(8):920–5.

    Article  PubMed  CAS  Google Scholar 

  63. Horowitz HW, Marks SJ, Weintraub M, Dumler JS. Brachial plexopathy associated with human granulocytic ehrlichiosis. Neurology. 1996;46(4):1026–9.

    Article  PubMed  CAS  Google Scholar 

  64. Dumler JS, Brouqui P, Aronson J, Taylor JP, Walker DH. Identification of Ehrlichia in human tissue. New Engl J Med. 1991;325(15):1109–10.

    Article  PubMed  CAS  Google Scholar 

  65. Dumler JS, Sutker WL, Walker DH. Persistent infection with Ehrlichia chaffeensis. Clin Infect Dis. 1993;17(5):903–5.

    Article  PubMed  CAS  Google Scholar 

  66. Olano JP, Hogrefe W, Seaton B, Walker DH. Clinical manifestations, epidemiology, and laboratory diagnosis of human monocytotropic ehrlichiosis in a commercial laboratory setting. Clin Diagn Lab Immunol. 2003;10(5):891–6.

    PubMed  Google Scholar 

  67. Ohyama K, Yamano Y, Chaki S, Kondo T, Inagami T. Domains for G-protein coupling in angiotensin II receptor type I: studies by site-directed mutagenesis. Biochem Biophys Res Commun. 1992;189(2):677–83.

    Article  PubMed  CAS  Google Scholar 

  68. Ratnasamy N, Everett ED, Roland WE, McDonald G, Caldwell CW. Central nervous system manifestations of human ehrlichiosis. Clin Infect Dis. 1996;23(2):314–9.

    Article  PubMed  CAS  Google Scholar 

  69. Harkess JR, Stucky D, Ewing SA. Neurologic abnormalities in a patient with human ehrlichiosis. South Med J. 1990;83(11):1341–3.

    Article  PubMed  CAS  Google Scholar 

  70. Bakken JS, Erlemeyer SA, Kanoff RJ, Silvestrini 2nd TC, Goodwin DD, Dumler JS. Demyelinating polyneuropathy associated with human granulocytic ehrlichiosis. Clin Infect Dis. 1998;27(5):1323–4.

    PubMed  CAS  Google Scholar 

  71. Dunn BE, Monson TP, Dumler JS, Morris CC, Westbrook AB, Duncan JL, et al. Identification of Ehrlichia chaffeensis morulae in cerebrospinal fluid mononuclear cells. J Clin Microbiol. 1992;30(8):2207–10.

    PubMed  CAS  Google Scholar 

  72. Grant AC, Hunter S, Partin WC. A case of acute monocytic ehrlichiosis with prominent neurologic signs. Neurology. 1997;48(6):1619–23.

    Article  PubMed  CAS  Google Scholar 

  73. Dhand A, Nadelman RB, Aguero-Rosenfeld M, Haddad FA, Stokes DP, Horowitz HW. Human granulocytic anaplasmosis during pregnancy: case series and literature review. Clin Infect Dis. 2007;45(5):589–93.

    Article  PubMed  Google Scholar 

  74. Kaiser R. Tick-borne encephalitis. Infect Dis Clin North Am. 2008;22(3):561–75.

    Article  PubMed  Google Scholar 

  75. Süss J. Epidemiology and ecology of TBE relevant to the production of effective vaccines. Vaccine. 2003;21 Suppl 1:S19–35.

    Article  PubMed  Google Scholar 

  76. Poponnikova TV. Specific clinical and epidemiological features of tick-borne encephalitis in western Siberia. Int J Med Microbiol. 2006;296 Suppl 40:59–62.

    Article  PubMed  Google Scholar 

  77. Centers for Disease Control and Prevention. Arboviral disease--United States, 1994. MMWR Morb Mortal Wkly Rep. 1995;44(35):641–4.

  78. McLean DM, Macpherson LW, Walker SJ, Funk G. Powassan virus: surveys of human and animal sera. Am J Public Health Nations Health. 1960;50(10):1539–44.

    Article  PubMed  CAS  Google Scholar 

  79. Romero JR, Simonsen KA. Powassan encephalitis and Colorado tick fever. Infect Dis Clin North Am. 2008;22(3):545–59.

    Article  PubMed  Google Scholar 

  80. Lindgren E, Gustafson R. Tick-borne encephalitis in Sweden and climate change. Lancet. 2001;358(9275):16–8.

    Article  PubMed  CAS  Google Scholar 

  81. Sumilo D, Asokliene L, Bormane A, Vasilenko V, Golovljova I, Randolph SE. Climate change cannot explain the upsurge of tick-borne encephalitis in the Baltics. PLoS One. 2007;2(6):e500.

    Article  PubMed  Google Scholar 

  82. Randolph SE. Evidence that climate change has caused 'emergence' of tick-borne diseases in Europe? Int J Med Microbiol. 2004;293 Suppl 37:5–15.

    PubMed  Google Scholar 

  83. Mandl CW, Holzmann H, Kunz C, Heinz FX. Complete genomic sequence of Powassan virus: evaluation of genetic elements in tick-borne versus mosquito-borne flaviviruses. Virology. 1993;194(1):173–84.

    Article  PubMed  CAS  Google Scholar 

  84. Kuno G, Artsob H, Karabatsos N, Tsuchiya KR, Chang GJ. Genomic sequencing of deer tick virus and phylogeny of Powassan-related viruses of North America. Am J Trop Med Hyg. 2001;65(5):671–6.

    PubMed  CAS  Google Scholar 

  85. Heinz FX, Mandl CW. The molecular biology of tick-borne encephalitis virus. Review article. APMIS. 1993;101(10):735–45.

    Article  PubMed  CAS  Google Scholar 

  86. Chunikhin SP, Stefuktina LF, Korolev MB, Reshetnikov IA, Khozinskaia GA. Sexual transmission of the tick-borne encephalitis virus in ixodid ticks (Ixodidae). Parazitologiia. 1983;17(3):214–7.

    PubMed  CAS  Google Scholar 

  87. Centers for Disease Control and Prevention. Outbreak of Powassan encephalitis--Maine and Vermont, 1999–2001. MMWR Morbid Mortal Wkly Report. 2001;50(35):761–4.

  88. Ebel GD, Foppa I, Spielman A, Telford 2nd SR. A focus of deer tick virus transmission in the northcentral United States. Emerg Infect Dis. 1999;5(4):570–4.

    Article  PubMed  CAS  Google Scholar 

  89. McLean DM, Cobb C, Gooderham SE, Smart CA, Wilson AG, Wilson WE. Powassan virus: persistence of virus activity during 1966. Can Med Assoc J. 1967;96(11):660–4.

    PubMed  CAS  Google Scholar 

  90. McLean DM, Larke RP. Powassan and Silverwater viruses: ecology of two Ontario arboviruses. Can Med Assoc J. 1963;88:182–5.

    PubMed  CAS  Google Scholar 

  91. Shope RE. Epidemiology of other arthropod-borne flaviviruses infecting humans. Adv Virus Res. 2003;61:373–91.

    Article  PubMed  Google Scholar 

  92. Ebel GD, Kramer LD. Short report: duration of tick attachment required for transmission of Powassan virus by deer ticks. Am J Trop Med Hyg. 2004;71(3):268–71.

    PubMed  Google Scholar 

  93. Lotric-Furlan S, Strle F. Thrombocytopenia, leukopenia and abnormal liver function tests in the initial phase of tick-borne encephalitis. Zentralbl Bakteriol. 1995;282(3):275–8.

    Article  PubMed  CAS  Google Scholar 

  94. Embil JA, Camfield P, Artsob H, Chase DP. Powassan virus encephalitis resembling herpes simplex encephalitis. Arch Int Med. 1983;143(2):341–3.

    Article  CAS  Google Scholar 

  95. Fitch WM, Artsob H. Powassan encephalitis in New Brunswick. Can Fam Physician. 1990;36:1289–90.

    PubMed  CAS  Google Scholar 

  96. Conway D, Rossier E. A case report: Powassan virus encephalitis with shoulder girdle involvement. Can Dis Wkly Rep. 1976;2(22):85–7.

    Google Scholar 

  97. Jackson A. Leg weakness associated with Powassan virus infection–Ontario. Can Dis Wkly Rep. 1989;15(24):123–4.

    PubMed  CAS  Google Scholar 

  98. Kaiser R. Tick-borne encephalitis in southwestern Germany. Infection. 1996;24(5):398–9.

    Article  PubMed  CAS  Google Scholar 

  99. Smith R, Woodall J, Whitney E, et al. Powassan virus infection: a report of three human cases of encephalitis. Am J Dis Child. 1974;27(5):691–3.

    Google Scholar 

  100. Lessell S, Collins TE. Ophthalmoplegia in Powassan encephalitis. Neurology. 2003;60(10):1726–7.

    Article  PubMed  Google Scholar 

  101. Rossier E, Harrison RJ, Lemieux B. A case of Powassan virus encephalitis. Can Med Assoc J. 1974;110(10):1173–4.

    PubMed  CAS  Google Scholar 

  102. Gholam BI, Puksa S, Provias JP. Powassan encephalitis: a case report with neuropathology and literature review. CMAJ. 1999;161(11):1419–22.

    PubMed  CAS  Google Scholar 

  103. Pikelj F, Tomazic J, Maticic M, Socan M, Muzlovic I. Severe forms of tick-borne meningoencephalitis in Slovenia. J Infect. 1995;31(1):83–5.

    Article  PubMed  CAS  Google Scholar 

  104. Mickiene A, Laiskonis A, Gunther G, Vene S, Lundkvist A, Lindquist L. Tickborne encephalitis in an area of high endemicity in Lithuania: disease severity and long-term prognosis. Clin Infect Dis. 2002;35(6):650–8.

    Article  PubMed  Google Scholar 

  105. Horger M, Beck R, Fenchel M, Ernemann U, Nagele T, Brodoefel H, et al. Imaging findings in tick-borne encephalitis with differential diagnostic considerations. AJR Am J Roentgenol. 2012;199(2):420–7.

    Article  PubMed  Google Scholar 

  106. Lindquist L, Vapalahti O. Tick-borne encephalitis. Lancet. 2008;371(9627):1861–71.

    Article  PubMed  Google Scholar 

  107. Emmons RW, Oshiro LS, Johnson HN, Lennette EH. Intra-erythrocytic location of Colorado tick fever virus. J Gen Virol. 1972;17(2):185–95.

    Article  PubMed  CAS  Google Scholar 

  108. Oshiro LS, Emmons RW. Electron microscopic observations of Colorado tick fever virus in BHK 21 and KB cells. J Gen Virol. 1968;3(2):279–80.

    Article  PubMed  CAS  Google Scholar 

  109. Murphy FA, Coleman PH, Harrison AK, Gary Jr GW. Colorado tick fever virus: an electron microscopic study. Virology. 1968;35(1):28–40.

    Article  PubMed  CAS  Google Scholar 

  110. Florio L, Stewart MO, Mugrage ER. The etiology of Colorado tick fever. J Exp Med. 1946;83:1–10.

    Article  Google Scholar 

  111. Leiby DA, Gill JE. Transfusion-transmitted tick-borne infections: a cornucopia of threats. Transfus Med Rev. 2004;18(4):293–306.

    Article  PubMed  Google Scholar 

  112. Earnest MP, Breckinridge JC, Barr RJ, Francy DB, Mollohan CS. Colorado tick fever. Clinical and epidemiologic features and evaluation of diagnostic methods. Rocky Mt Med J. 1971;68(2):60–2.

    PubMed  CAS  Google Scholar 

  113. Goodpasture HC, Poland JD, Francy DB, Bowen GS, Horn KA. Colorado tick fever: clinical, epidemiologic, and laboratory aspects of 228 cases in Colorado in 1973–1974. Ann Intern Med. 1978;88(3):303–10.

    Article  PubMed  CAS  Google Scholar 

  114. Tsai T. Colorado tick fever. In: Mandell G, Bennett J, Dolin R, editors. Principles and practice of infectious diseases. 6th ed. Amsterdam: Elsevier; 2005. p. 1900–1.

    Google Scholar 

  115. Spruance SL, Bailey A. Colorado tick fever. a review of 115 laboratory confirmed cases. Arch Intern Med. 1973;131(2):288–93.

    Article  PubMed  CAS  Google Scholar 

  116. Loge RV. Acute hepatitis associated with Colorado tick fever. West J Med. 1985;142(1):91–2.

    PubMed  CAS  Google Scholar 

  117. Hierholzer WJ, Barry DW. Colorado tick fever pericarditis. JAMA. 1971;217(6):825.

    Article  PubMed  CAS  Google Scholar 

  118. Eklund CM, Kohls GM, Brennan JM. Distribution of Colorado tick fever and virus-carrying ticks. J Am Med Assoc. 1955;157(4):335–7.

    Article  PubMed  CAS  Google Scholar 

  119. Fitz RH, Meiklejohn G. Colorado tick fever. Postgrad Med. 1958;23(2):113–8.

    PubMed  CAS  Google Scholar 

  120. Fraser CH, Schiff DW. Colorado tick fever encephalitis. Report of a case. Pediatrics. 1962;29:187–90.

    PubMed  CAS  Google Scholar 

  121. Emmons RW, Lennette EH. Immunofluorescent staining in the laboratory diagnosis of Colorado tick fever. J Lab Clin Med. 1966;68(6):923–9.

    PubMed  CAS  Google Scholar 

  122. Emmons RW, Dondero DV, Devlin V, Lennette EH. Serologic diagnosis of Colorado tick fever. A comparison of complement-fixation, immunofluorescence, and plaque-reduction methods. Am J Trop Med Hyg. 1969;18(5):796–802.

    PubMed  CAS  Google Scholar 

  123. Attoui H, Billoir F, Bruey JM, de Micco P, de Lamballerie X. Serologic and molecular diagnosis of Colorado tick fever viral infections. Am J Trop Med Hyg. 1998;59(5):763–8.

    PubMed  CAS  Google Scholar 

  124. Johnson AJ, Karabatsos N, Lanciotti RS. Detection of Colorado tick fever virus by using reverse transcriptase PCR and application of the technique in laboratory diagnosis. J Clin Microbiol. 1997;35(5):1203–8.

    PubMed  CAS  Google Scholar 

  125. Goodman JL, Dennis DT, Sonenshine DE, editors. Tick-borne diseases of humans. Washington: ASM Press; 2005.

    Google Scholar 

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Acknowledgment

Alexandros C. Tselis has received grant support from the US Department of Defense.

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Navid Seraji-Bozorgzad declares that he has no conflict of interest.

Alexandros C. Tselis receives royalties from Taylor and Francis for a textbook.

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Seraji-Bozorgzad, N., Tselis, A.C. Non-Lyme Tick-Borne Diseases: A Neurological Perspective. Curr Neurol Neurosci Rep 13, 388 (2013). https://doi.org/10.1007/s11910-013-0388-6

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