Skip to main content
SpringerLink
Log in

Autologous Islet Transplantation in Patients Requiring Pancreatectomy for Neoplasm

  • Transplantation (A Pileggi, Section Editor)
  • Published:
Current Diabetes Reports Aims and scope Submit manuscript

Abstract

Autologous islet cell transplantation is a procedure performed to prevent or reduce the severity of diabetes after pancreatic resection. Autologous islet cell transplantation is being used almost exclusively in patients undergoing pancreatectomy because of painful, chronic pancreatitis, or multiple recurrent episodes of pancreatitis that is not controlled by standard medical and surgical treatments. Here, we discuss the possibility of extending the clinical indications for this treatment on the basis of our experience in patients undergoing pancreatic surgery for both nonmalignant and malignant diseases, including patients undergoing completion pancreatectomy because of anastomosis leakage after pancreaticoduodenectomy and those with pancreatic anastomosis deemed at high risk for failure.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Maeda H, Hanazaki K. Pancreatogenic diabetes after pancreatic resection. Pancreatology. 2011;11:268–76. This is a state-of-the-art review of pancreatogenic diabetes.

    Article  PubMed  Google Scholar 

  2. Cui Y, Andersen DK. Pancreatogenic diabetes: special considerations for management. Pancreatology. 2011;11:279–94.

    Article  PubMed  Google Scholar 

  3. Parsaik AK, Murad MH, Sathananthan A, et al. Metabolic and target organ outcomes after total pancreatectomy: Mayo Clinic experience and meta-analysis of the literature. Clin Endocrinol. 2010;73:723–31. This systematic review and meta-analysis focused on the clinical outcomes of total pancreatectomy in a large tertiary center, demonstrating that hypoglycemic episodes continue to be a major problem of pancreatogenic diabetes.

    Article  Google Scholar 

  4. Pezzilli R. Diabetic control after total pancreatectomy. Dig Liver Dis. 2006;38:420–2.

    Article  CAS  PubMed  Google Scholar 

  5. Jethwa P, Sodergren M, Lala A, et al. Diabetic control after total pancreatectomy. Dig Liver Dis. 2006;38:415–9.

    Article  CAS  PubMed  Google Scholar 

  6. Stauffer JA, Nguyen JH, Heckman MG, et al. Patient outcomes after total pancreatectomy: a single centre contemporary experience. HPB (Oxford). 2009;11:483–92.

    Article  Google Scholar 

  7. Muller MW, Friess H, Kleeff J, et al. Is there still a role for total pancreatectomy? Ann Surg. 2007;246:966–74. discussion 974–5.

    Article  PubMed  Google Scholar 

  8. Lahat G, Ben Haim M, Nachmany I, et al. Pancreatic incidentalomas: high rate of potentially malignant tumors. J Am Coll Surg. 2009;209:313–9.

    Article  PubMed  Google Scholar 

  9. Lemmens VE, Bosscha K, van der Schelling G, et al. Improving outcome for patients with pancreatic cancer through centralization. Br J Surg. 2011;98:1455–62.

    Article  CAS  PubMed  Google Scholar 

  10. Balzano G, Zerbi A, Capretti G, et al. Effect of hospital volume on outcome of pancreaticoduodenectomy in Italy. Br J Surg. 2008;95:357–62.

    Article  CAS  PubMed  Google Scholar 

  11. Priestley JT, Comfort MW, Sprague RG. Total pancreatectomy for hyperinsulinism due to islet-cell adenoma: follow-up report 5 1/2 years after operation, including metabolic studies. Ann Surg. 1949;130:211–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Slezak LA, Andersen DK. Pancreatic resection: effects on glucose metabolism. World J Surg. 2001;25:452–60.

    Article  CAS  PubMed  Google Scholar 

  13. Alberti K. Diabetes secondary to pancreatopathy: an example of brittle diabetes. In: Diabetes Secondary to Pancreatopathy. International Congress Series 762. Tiengo A, DelPrato S, Vranic M, editors. Amsterdam: Excerpta Medica; 1988. p. 7–20.

  14. Billings BJ, Christein JD, Harmsen WS, et al. Quality-of-life after total pancreatectomy: is it really that bad on long-term follow-up? J Gastrointest Surg. 2005;9:1059–66. discussion 1066–7.

    Article  PubMed  Google Scholar 

  15. Kahl S, Malfertheiner P. Exocrine and endocrine pancreatic insufficiency after pancreatic surgery. Best Pract Res Clin Gastroenterol. 2004;18:947–55.

    Article  PubMed  Google Scholar 

  16. Hutchins RR, Hart RS, Pacifico M, et al. Long-term results of distal pancreatectomy for chronic pancreatitis in 90 patients. Ann Surg. 2002;236:612–8.

    Article  PubMed Central  PubMed  Google Scholar 

  17. Hutchins RR, Kojodjojo P, Ho R, et al. Short and long-term outcome of pancreatic surgery in a district general hospital. J R Coll Surg Edinb. 2002;47:548–51.

    CAS  PubMed  Google Scholar 

  18. Reddy S, Wolfgang CL, Cameron JL, et al. Total pancreatectomy for pancreatic adenocarcinoma: evaluation of morbidity and long-term survival. Ann Surg. 2009;250:282–7.

    Article  PubMed  Google Scholar 

  19. Sakata N, Egawa S, Motoi F, et al. Institutional indications for islet transplantation after total pancreatectomy. J Hepatobiliary Pancreat Surg. 2008;15:488–92.

    Article  PubMed  Google Scholar 

  20. Gaia E, Salacone P. Medical complications of pancreatic resections. JOP. 2007;8:114–7.

    PubMed  Google Scholar 

  21. Andersen DK, Andren-Sandberg A, Duell EJ, et al. Pancreatitis-diabetes-pancreatic cancer: summary of an NIDDK-NCI workshop. Pancreas. 2013;42:1227–37.

    Article  CAS  PubMed  Google Scholar 

  22. Roberts KJ, Blanco G, Webber J, et al. How severe is diabetes after total pancreatectomy? A case-matched analysis. HPB (Oxford). 2013

  23. Nosadini R, del Prato S, Tiengo A, et al. Insulin sensitivity, binding, and kinetics in pancreatogenic and type I diabetes. Diabetes. 1982;31:346–55.

    Article  CAS  PubMed  Google Scholar 

  24. Gall FP, Muhe E, Gebhardt C. Results of partial and total pancreaticoduodenectomy in 117 patients with chronic pancreatitis. World J Surg. 1981;5:269–75.

    Article  CAS  PubMed  Google Scholar 

  25. Muggeo M, Moghetti P, Faronato PP, et al. Insulin receptors on circulating blood cells from patients with pancreatogenic diabetes: a comparison with type I diabetes and normal subjects. J Endocrinol Invest. 1987;10:311–9.

    Article  CAS  PubMed  Google Scholar 

  26. Seymour NE, Volpert AR, Lee EL, et al. Alterations in hepatocyte insulin binding in chronic pancreatitis: effects of pancreatic polypeptide. Am J Surg. 1995;169:105–9. discussion 110.

    Article  CAS  PubMed  Google Scholar 

  27. Andersen DK, Ruiz CL, Burant CF. Insulin regulation of hepatic glucose transporter protein is impaired in chronic pancreatitis. Ann Surg. 1994;219:679–86. discussion 686–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  28. Seymour NE, Spector SA, Andersen DK, et al. Overexpression of hepatic pancreatic polypeptide receptors in chronic pancreatitis. J Surg Res. 1998;76:47–52.

    Article  CAS  PubMed  Google Scholar 

  29. Inoue K, Tobe T, Suzuki T, et al. Plasma cholecystokinin and pancreatic polypeptide response after radical pancreatoduodenectomy with Billroth I and Billroth II type of reconstruction. Ann Surg. 1987;206:148–54.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  30. Sive A, Vinik AI, Van Tonder S, Lund A. Impaired pancreatic polypeptide secretion in chronic pancreatitis. J Clin Endocrinol Metab. 1978;47:556–9.

    Article  CAS  PubMed  Google Scholar 

  31. Adrian TE, McKiernan J, Johnstone DI, et al. Hormonal abnormalities of the pancreas and gut in cystic fibrosis. Gastroenterology. 1980;79:460–5.

    CAS  PubMed  Google Scholar 

  32. Bajorunas DR, Fortner JG, Jaspan J, Sherwin RS. Total pancreatectomy increases the metabolic response to glucagon in humans. J Clin Endocrinol Metab. 1986;63:439–46.

    Article  CAS  PubMed  Google Scholar 

  33. Schrader H, Menge BA, Breuer TG, et al. Impaired glucose-induced glucagon suppression after partial pancreatectomy. J Clin Endocrinol Metab. 2009;94:2857–63.

    Article  CAS  PubMed  Google Scholar 

  34. Donowitz M, Hendler R, Spiro HM, et al. Glucagon secretion in acute and chronic pancreatitis. Ann Intern Med. 1975;83:778–81.

    Article  CAS  PubMed  Google Scholar 

  35. Linehan IP, Lambert MA, Brown DC, et al. Total pancreatectomy for chronic pancreatitis. Gut. 1988;29:358–65.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  36. Knop FK, Vilsboll T, Larsen S, et al. Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution. Am J Physiol Endocrinol Metab. 2007;292:E324–30.

    Article  CAS  PubMed  Google Scholar 

  37. Ewald N, Bretzel RG, Fantus IG, et al. Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-center trial. Diabetes Metab Res Rev. 2007;23:386–91.

    Article  CAS  PubMed  Google Scholar 

  38. Kendall DM, Sutherland DE, Najarian JS, et al. Effects of hemipancreatectomy on insulin secretion and glucose tolerance in healthy humans. N Engl J Med. 1990;322:898–903.

    Article  CAS  PubMed  Google Scholar 

  39. Kumar AF, Gruessner RW, Seaquist ER. Risk of glucose intolerance and diabetes in hemipancreatectomized donors selected for normal preoperative glucose metabolism. Diabetes Care. 2008;31:1639–43.

    Article  PubMed Central  PubMed  Google Scholar 

  40. Malka D, Hammel P, Sauvanet A, et al. Risk factors for diabetes mellitus in chronic pancreatitis. Gastroenterology. 2000;119:1324–32.

    Article  CAS  PubMed  Google Scholar 

  41. Andersen DK, Frey CF. The evolution of the surgical treatment of chronic pancreatitis. Ann Surg. 2010;251:18–32.

    Article  PubMed  Google Scholar 

  42. Bellin MD, Balamurugan AN, Pruett TL, Sutherland DE. No islets left behind: islet autotransplantation for surgery-induced diabetes. Curr Diab Rep. 2012;12:580–6.

    Article  PubMed Central  PubMed  Google Scholar 

  43. Bramis K, Gordon-Weeks AN, Friend PJ, et al. Systematic review of total pancreatectomy and islet autotransplantation for chronic pancreatitis. Br J Surg. 2012;99:761–6.

    Article  CAS  PubMed  Google Scholar 

  44. Dong M, Parsaik AK, Erwin PJ, et al. Systematic review and meta-analysis: islet autotransplantation after pancreatectomy for minimizing diabetes. Clin Endocrinol. 2011;75:771–9.

    Article  Google Scholar 

  45. Najarian JS, Sutherland DE, Matas AJ, Goetz FC. Human islet autotransplantation following pancreatectomy. Transplant Proc. 1979;11:336–40.

    CAS  PubMed  Google Scholar 

  46. Piemonti L, Pileggi A. 25 Years of the Ricordi Automated Method for islet isolation. CellR4. 2013;1:e128.

    Google Scholar 

  47. Sutherland DE, Radosevich DM, Bellin MD, et al. Total pancreatectomy and islet autotransplantation for chronic pancreatitis. J Am Coll Surg. 2012;214:409–24. This is the largest published cohort of IAT after pancreatectomy for chronic pancreatitis.

    Article  PubMed Central  PubMed  Google Scholar 

  48. Bellin MD, Beilman GJ, Dunn TB, et al. Islet autotransplantation to preserve beta cell mass in selected patients with chronic pancreatitis and diabetes mellitus undergoing total pancreatectomy. Pancreas. 2013;42:317–21.

    Article  PubMed Central  PubMed  Google Scholar 

  49. Bellin MD, Freeman ML, Schwarzenberg SJ, et al. Quality of life improves for pediatric patients after total pancreatectomy and islet autotransplant for chronic pancreatitis. Clin Gastroenterol Hepatol. 2011;9:793–9.

    Article  PubMed Central  PubMed  Google Scholar 

  50. Bellin MD, Carlson AM, Kobayashi T, et al. Outcome after pancreatectomy and islet autotransplantation in a pediatric population. J Pediatr Gastroenterol Nutr. 2008;47:37–44.

    Article  PubMed  Google Scholar 

  51. Wilson GC, Sutton JM, Salehi M, et al. Surgical outcomes after total pancreatectomy and islet cell autotransplantation in pediatric patients. Surgery. 2013;154:777–83. discussion 783–4.

    Article  PubMed  Google Scholar 

  52. Sutton JM, Schmulewitz N, Sussman JJ, et al. Total pancreatectomy and islet cell autotransplantation as a means of treating patients with genetically linked pancreatitis. Surgery. 2010;148:676–85. discussion 685–6.

    Article  PubMed  Google Scholar 

  53. Webb MA, Illouz SC, Pollard CA, et al. Islet auto transplantation following total pancreatectomy: a long-term assessment of graft function. Pancreas. 2008;37:282–7.

    Article  PubMed  Google Scholar 

  54. Clayton HA, Davies JE, Pollard CA, et al. Pancreatectomy with islet autotransplantation for the treatment of severe chronic pancreatitis: the first 40 patients at the Leicester General Hospital. Transplantation. 2003;76:92–8.

    Article  PubMed  Google Scholar 

  55. White SA, Davies JE, Pollard C, et al. Pancreas resection and islet autotransplantation for end-stage chronic pancreatitis. Ann Surg. 2001;233:423–31.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  56. Garcea G, Weaver J, Phillips J, et al. Total pancreatectomy with and without islet cell transplantation for chronic pancreatitis: a series of 85 consecutive patients. Pancreas. 2009;38:1–7.

    Article  PubMed  Google Scholar 

  57. Ahmad SA, Lowy AM, Wray CJ, et al. Factors associated with insulin and narcotic independence after islet autotransplantation in patients with severe chronic pancreatitis. J Am Coll Surg. 2005;201:680–7.

    Article  PubMed  Google Scholar 

  58. Morgan KA, Nishimura M, Uflacker R, Adams DB. Percutaneous transhepatic islet cell autotransplantation after pancreatectomy for chronic pancreatitis: a novel approach. HPB (Oxford). 2011;13:511–6.

    Article  Google Scholar 

  59. Sutherland DE, Gruessner AC, Carlson AM, et al. Islet autotransplant outcomes after total pancreatectomy: a contrast to islet allograft outcomes. Transplantation. 2008;86:1799–802.

    Article  PubMed  Google Scholar 

  60. Dudeja V, Beilman GJ, Vickers SM. Total pancreatectomy with islet autotransplantation in patients with malignancy: are we there yet? Ann Surg. 2013;258:219–20.

    Article  PubMed  Google Scholar 

  61. Balzano G, Maffi P, Nano R, et al. Extending indications for islet autotransplantation in pancreatic surgery. Ann Surg. 2013;258:210–8. This is the largest published cohort of IAT after pancreatectomy for diseases other than chronic pancreatitis.

    Article  PubMed  Google Scholar 

  62. Ris F, Niclauss N, Morel P, et al. Islet autotransplantation after extended pancreatectomy for focal benign disease of the pancreas. Transplantation. 2011;91:895–901. This article reports on a cohort of IAT after partial pancreatectomy for benign neoplasm with longer follow-up.

    Article  PubMed  Google Scholar 

  63. Jin SM, Oh SH, Kim SK, et al. Diabetes-free survival in patients who underwent islet autotransplantation after 50 % to 60 % distal partial pancreatectomy for benign pancreatic tumors. Transplantation. 2013;95:1396–403. This is the largest published cohort of IAT after partial pancreatectomy for benign neoplasm.

    Article  PubMed  Google Scholar 

  64. Launois B, Franci J, Bardaxoglou E, et al. Total pancreatectomy for ductal adenocarcinoma of the pancreas with special reference to resection of the portal vein and multicentric cancer. World J Surg. 1993;17:122–6. discussion 126–7.

    Article  CAS  PubMed  Google Scholar 

  65. Tryka AF, Brooks JR. Histopathology in the evaluation of total pancreatectomy for ductal carcinoma. Ann Surg. 1979;190:373–81.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  66. Motojima K, Urano T, Nagata Y, et al. Detection of point mutations in the Kirsten-ras oncogene provides evidence for the multicentricity of pancreatic carcinoma. Ann Surg. 1993;217:138–43.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  67. Balamurugan AN, Loganathan G, Bellin MD, et al. A new enzyme mixture to increase the yield and transplant rate of autologous and allogeneic human islet products. Transplantation. 2012;93:693–702.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  68. Karpoff HM, Klimstra DS, Brennan MF, Conlon KC. Results of total pancreatectomy for adenocarcinoma of the pancreas. Arch Surg. 2001;136:44–7. discussion 48.

    Article  CAS  PubMed  Google Scholar 

  69. Schnelldorfer T, Lombardo KR, Farnell M, Sarr M. Total Pancreatectomy for Treatment of Pancreatic Adenocarcinoma. In: Lowy A, Leach S, Philip P, editors. Pancreatic Cancer. US: Springer; 2008. p. p. 329–39.

    Chapter  Google Scholar 

  70. Kloppel G, Lohse T, Bosslet K, Ruckert K. Ductal adenocarcinoma of the head of the pancreas: incidence of tumor involvement beyond the Whipple resection line. Histological and immunocytochemical analysis of 37 total pancreatectomy specimens. Pancreas. 1987;2:170–5.

    Article  CAS  PubMed  Google Scholar 

  71. Kobayashi T, Sato Y, Hirukawa H, et al. Total pancreatectomy combined with partial pancreas autotransplantation for recurrent pancreatic cancer: a case report. Transplant Proc. 2012;44:1176–9.

    Article  CAS  PubMed  Google Scholar 

  72. Alsaif F, Molinari M, Al-Masloom A, et al. Pancreatic islet autotransplantation with completion pancreatectomy in the management of uncontrolled pancreatic fistula after whipple resection for ampullary adenocarcinoma. Pancreas. 2006;32:430–1.

    Article  PubMed  Google Scholar 

  73. Forster S, Liu X, Adam U, et al. Islet autotransplantation combined with pancreatectomy for treatment of pancreatic adenocarcinoma: a case report. Transplant Proc. 2004;36:1125–6.

    Article  CAS  PubMed  Google Scholar 

  74. Iyegha UP, Asghar JA, Beilman GJ. Total pancreatectomy and islet auto-transplantation as treatment for ampullary adenocarcinoma in the setting of pancreatic ductal disruption secondary to acute necrotizing pancreatitis. A case report. JOP. 2012;13:239–42.

    PubMed  Google Scholar 

  75. Lee BW, Jee JH, Heo JS, et al. The favorable outcome of human islet transplantation in Korea: experiences of 10 autologous transplantations. Transplantation. 2005;79:1568–74.

    Article  PubMed  Google Scholar 

  76. Callery MP, Pratt WB, Vollmer Jr CM. Prevention and management of pancreatic fistula. J Gastrointest Surg. 2009;13:163–73.

    Article  PubMed  Google Scholar 

  77. Kuroki T, Tajima Y, Kanematsu T. Surgical management for the prevention of pancreatic fistula following distal pancreatectomy. J Hepatobiliary Pancreat Surg. 2005;12:283–5.

    Article  PubMed  Google Scholar 

  78. Niedergethmann M, Farag Soliman M, Post S. Postoperative complications of pancreatic cancer surgery. Minerva Chir. 2004;59:175–83.

    CAS  PubMed  Google Scholar 

  79. Bassi C, Dervenis C, Butturini G, et al. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery. 2005;138:8–13.

    Article  PubMed  Google Scholar 

  80. Bassi C, Butturini G, Molinari E, et al. Pancreatic fistula rate after pancreatic resection. The importance of definitions. Dig Surg. 2004;21:54–9.

    Article  PubMed  Google Scholar 

  81. Yeo CJ, Cameron JL, Maher MM, et al. A prospective randomized trial of pancreaticogastrostomy vs pancreaticojejunostomy after pancreaticoduodenectomy. Ann Surg. 1995;222:580–8. discussion 588–92.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  82. Strasberg SM, Linehan DC, Clavien PA, Barkun JS. Proposal for definition and severity grading of pancreatic anastomosis failure and pancreatic occlusion failure. Surgery. 2007;141:420–6.

    Article  PubMed  Google Scholar 

  83. Richter A, Niedergethmann M, Sturm JW, et al. Long-term results of partial pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head: 25-year experience. World J Surg. 2003;27:324–9.

    Article  PubMed  Google Scholar 

  84. Batignani G, Fratini G, Zuckermann M, et al. Comparison of Wirsung-jejunal duct-to-mucosa and dunking technique for pancreatojejunostomy after pancreatoduodenectomy. Hepatobiliary Pancreat Dis Int. 2005;4:450–5.

    PubMed  Google Scholar 

  85. Yeo CJ. The Johns Hopkins experience with pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma. J Gastrointest Surg. 2000;4:231–2.

    Article  CAS  PubMed  Google Scholar 

  86. Matsumoto Y, Fujii H, Miura K, et al. Successful pancreatojejunal anastomosis for pancreatoduodenectomy. Surg Gynecol Obstet. 1992;175:555–62.

    CAS  PubMed  Google Scholar 

  87. Kojima Y, Katayama K, Note M, et al. Pancreaticojejunostomy and pancreatic leakage after pancreaticoduodenectomy. Int Surg. 1992;77:80–3.

    CAS  PubMed  Google Scholar 

  88. Kollmar O, Moussavian MR, Bolli M, et al. Pancreatojejunal leakage after pancreas head resection: anatomic and surgeon-related factors. J Gastrointest Surg. 2007;11:1699–703.

    Article  CAS  PubMed  Google Scholar 

  89. Pratt WB, Callery MP, Vollmer Jr CM. Risk prediction for development of pancreatic fistula using the ISGPF classification scheme. World J Surg. 2008;32:419–28.

    Article  PubMed  Google Scholar 

  90. Balzano G, Pecorelli N, Piemonti L, et al. Relaparotomy for a pancreatic fistula after a pancreaticoduodenectomy: a comparison of different surgical strategies. HPB (Oxford). 2014;16:40–5.

    Article  Google Scholar 

  91. Christoffersson G, Henriksnas J, Johansson L, et al. Clinical and experimental pancreatic islet transplantation to striated muscle: establishment of a vascular system similar to that in native islets. Diabetes. 2010;59:2569–78.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  92. Berney T, Mathe Z, Bucher P, et al. Islet autotransplantation for the prevention of surgical diabetes after extended pancreatectomy for the resection of benign tumors of the pancreas. Transplant Proc. 2004;36:1123–4.

    Article  CAS  PubMed  Google Scholar 

  93. Oberholzer J, Mathe Z, Bucher P, et al. Islet autotransplantation after left pancreatectomy for non-enucleable insulinoma. Am J Transplant. 2003;3:1302–7.

    Article  PubMed  Google Scholar 

  94. Garraway NR, Dean S, Buczkowski A, et al. Islet autotransplantation after distal pancreatectomy for pancreatic trauma. J Trauma. 2009;67:E187–9.

    Article  PubMed  Google Scholar 

  95. Dardenne S, Sterkers A, Leroy C, et al. Laparoscopic spleen-preserving distal pancreatectomy followed by intramuscular autologous islet transplantation for traumatic pancreatic transection in a young adult. JOP. 2012;13:285–8.

    PubMed  Google Scholar 

  96. Sakata N, Goto M, Motoi F, et al. Clinical experiences in the treatment of pancreatic arteriovenous malformation by total pancreatectomy with islet autotransplantation. Transplantation. 2013;96:e38–40.

    Article  PubMed  Google Scholar 

  97. Jung HS, Choi SH, Kim SJ, et al. Delayed improvement of insulin secretion after autologous islet transplantation in partially pancreatectomized patients. Metabolism. 2009;58:1629–35.

    Article  CAS  PubMed  Google Scholar 

  98. Gala-Lopez BL, Semlacher E, Manouchehri N, et al. Autologous islet transplantation after total pancreatectomy for renal cell carcinoma metastases. Am J Transplant. 2013;13:2487–91.

    Article  CAS  PubMed  Google Scholar 

  99. Khan A, Jindal RM, Shriver C, et al. Remote processing of pancreas can restore normal glucose homeostasis in autologous islet transplantation after traumatic whipple pancreatectomy: technical considerations. Cell Transplant. 2012;21:1261–7.

    Article  PubMed  Google Scholar 

  100. Jindal RM, Ricordi C, Shriver CD. Autologous pancreatic islet transplantation for severe trauma. N Engl J Med. 2010;362:1550.

    Article  CAS  PubMed  Google Scholar 

  101. Liu X, Forster S, Adam U, et al. Islet autotransplantation combined with total pancreatectomy for treatment of pancreatic adenocarcinoma. Transplant Proc. 2001;33:662–3.

    Article  CAS  PubMed  Google Scholar 

Download references

Compliance with Ethics Guidelines

Conflict of Interest

Gianpaolo Balzano declares that he has no conflict of interest. Lorenzo Piemonti reports grants from Ministry of Health; Ministry of University; and grants and personal fees from Dompè Spa, personal fees from Sigma Tau.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Author information

Authors and Affiliations

  1. Pancreatic Surgery Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

    Gianpaolo Balzano

  2. Division of Immunology, Transplantation and Infectious Diseases, Diabetes Research Institute (DRI),IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy

    Lorenzo Piemonti

Authors
  1. Gianpaolo Balzano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lorenzo Piemonti
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lorenzo Piemonti.

Additional information

This article is part of the Topical Collection on Transplantation

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Balzano, G., Piemonti, L. Autologous Islet Transplantation in Patients Requiring Pancreatectomy for Neoplasm. Curr Diab Rep 14, 512 (2014). https://doi.org/10.1007/s11892-014-0512-2

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11892-014-0512-2

Keywords

Search

Navigation