Skip to main content
SpringerLink
Log in

Influence of New Modified Biliopancreatic Diversion on Blood Glucose and Lipids in GK rats

  • Original Contributions
  • Published:
Obesity Surgery Aims and scope Submit manuscript

Abstract

Background

This study aimed to investigate the influence of new biliopancreatic diversion (NBPD) and duodenal-jejunal bypass (DJB) surgery on blood glucose, lipids, gastrointestinal hormones, and insulin in Goto-Kakizaki (GK) rats, an animal model for type 2 diabetes, in order to elucidate the mechanisms underlying the therapeutic effect of these types of surgery on this clinical condition.

Methods

Thirty 30 male GK rats (SPF) aged 12 weeks were randomly assigned into three groups (n = 10 per group): sham group, NBPD group, and DJB group. Body weight, random plasma glucose, fasting plasma glucose (FPG), oral glucose tolerance (OGT), blood lipids, plasma insulin, glucagon like peptide-1 (GLP-1), and gastric inhibitory polypeptide (GIP) were measured before and after surgery.

Results

NBPD surgery improved glucose tolerance, decreased fasting free fatty acids, triglycerides, and cholesterol. It also increased fasting and postprandial GIP, but caused no change in GLP-1. DJB surgery produced results similar to NBPD surgery except for causing a decrease in postprandial GLP-1 and insulin, and a larger increase in fasting GIP.

Conclusions

Moving the biliopancreatic duct outlet to the mid-jejunum (NBPD surgery) improves glucose tolerance and increases GIP, but does not change GLP-1. Adding duodenal bypass (DJB surgery) increases fasting GIP and decreases postprandial GLP-1.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Rubino F, Marescaux J. Effect of duodenal–jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease. Ann Surg. 2004;239:1–11.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Alleotti E, Palma RT, Pinto Jr PE, et al. Biliopancreatic diversion with duodenojenunal exclusion associated with truncal vagotomy. A new proposal for type 2 diabetes mellitus treatment. Acta Cirirgica Brasil. 2012;27:577–84.

    Article  Google Scholar 

  3. Koehestanie P, Dogan K, Berends F, et al. Duodenal-jejunal bypass liner implantation provokes rapid weight loss and improved glycemic control, accompanied by elevated fasting ghrelin levels. Endosc Int Open. 2014. doi:10.1055/s-0034-1365222.

    PubMed  PubMed Central  Google Scholar 

  4. Raffaelli M, Iaconelli A, Nanni G, et al. Effects of biliopancreatic diversion on diurnal leptin, insulin and free fatty acid levels. BJS. 2015;102:682–90.

    Article  CAS  Google Scholar 

  5. Gan SS, Talbot ML, Jorgensen JO. Efficacy of surgery in the management of obesity-related type 2 diabetes mellitus. ANZ J Surg. 2007;77(11):958–62.

    Article  PubMed  Google Scholar 

  6. Pereferrer FS, Gonzalez MH, Rovira AF, et al. Influence of sleeve gastrectomy on several experimental models of obesity: metabolic and hormonal implications. Obes Surg. 2008;18(1):97–108.

    Article  PubMed  Google Scholar 

  7. American Diabetes Association. Standards of medical care in diabetes—2010. Diabetes Care. 2010;33:692.

    Article  Google Scholar 

  8. Adams TD, Gress RE, Smith SC, et al. Long-term mortality after gastric bypass surgery. N Engl J Med. 2007;357(8):753–61.

    Article  CAS  PubMed  Google Scholar 

  9. Sjöström L, Narbro K, Sjöström CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357:741–52.

    Article  PubMed  Google Scholar 

  10. Akash MSH, Rehman K, Chen S. Goto-kakizaki rats: Suitability as non-obese diabetic animal model for spontaneous type 2 diabetes mellitus. Curr Diabetes Rev. 2013;9:1–10.

    Article  Google Scholar 

  11. Weng S-G. Modified biliopancreatic diversion for GK rats: a proposal for a simpler technique and mechanism research. Obes Surg. 2012;22:997–8.

    Article  PubMed  Google Scholar 

  12. Weng SG, Zhang B, Feng S, et al. Effects of modified biliopancreatic diversion on glucose tolerance of GK rats. Obes Surg. 2012;23:522–30.

    Article  Google Scholar 

  13. Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007;132(6):2131–57.

    Article  CAS  PubMed  Google Scholar 

  14. Drucker DJ. The role of gut hormones in glucose homeostasis. J Clin Invest. 2007;117:24–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Nauck MA, Heimesaat MM, Orskov C, et al. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest. 1993;91:301–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Young AA, Gedulin B, Vine W, et al. Gastric emptying is accelerated in diabetic BB rats and is slowed by subcutaneous injections of amylin. Diabetologia. 1995;38:642–8.

    Article  CAS  PubMed  Google Scholar 

  17. Han H, Wang L, Du H, et al. Expedited biliopancreatic juice flow to the distal gut benefits the diabetes control after duodenal jejunal bypass. Obes Surg. 2015;25:1802–9.

    Article  PubMed  Google Scholar 

  18. Zhang GY, Wang TT, Cheng ZQ, et al. Resolution of diabetes mellitus by ileal transposition compared with bilioancreatic diversion in a nonobese animal model of diabetes. Can J Surg. 2011;54:243–51.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Patriti A, Aisa M, Annetti C, et al. How the hindgut can cure type 2 diabetes. Ileal transposition improves glucose metabolism and beta-cell function in Goto-kakizaki rats through an enhanced proglucagon gene expression and L-cell number. Surgery. 2007;142(1):74–85.

    Article  PubMed  Google Scholar 

  20. Speck M, Cho YM, Asadi A, et al. Duodenal-jejunal bypass protects GK rats from b-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1. Am J Physiol Endocrinol Metab. 2011;300:E923–32.

    Article  CAS  PubMed  Google Scholar 

  21. Charles MA, Eschwege E, Thibult N, et al. The role of NEFA in the deterioration of glucose tolerance in Caucasian subjects:result of the pairs prospective study. Diabetologia. 1997;40:1101–9.

    Article  CAS  PubMed  Google Scholar 

  22. Taskinen MR, Bogardus C, Kennedy A, et al. Multiple disturbances of free fatty acid metabolism in noninsulin-dependent diabetes. Effect of oral hypoglycemic therapy. J Clin Invest. 1985;76(2):637–44.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Boden G. Does inhibition of beta cell proliferation by free fatty acid in mice explain the progressive failure of insulin secretion in type 2 diabetes? Diabetes. 2012;61(3):560–1.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hepatopancreatobiliary Surgery Department, the First Affiliated Hospital of Fujian Medical University, No 20 Chazhong Road, Fuzhou City, Fujian, People’s Republic of China

    Shangeng Weng, Bin Zhang, Changguo Xu, Su Feng & Hongxing He

Authors
  1. Shangeng Weng
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bin Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Changguo Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Su Feng
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hongxing He
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shangeng Weng.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of informed consent

Not applicable

Statement of human and animal rights

All applicable institutional and/or national guidelines for the care and use of animals were followed.

Additional information

Supported by: The Fujian Provincial Natural Science Foundation, No. 2014J01312. Training Project of Young Talents in Health System of Fujian Province, No.2014-ZQN-ZD-17. Professor Development Fund of Fujian Medical University, No.JS14020.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Weng, S., Zhang, B., Xu, C. et al. Influence of New Modified Biliopancreatic Diversion on Blood Glucose and Lipids in GK rats. OBES SURG 27, 657–664 (2017). https://doi.org/10.1007/s11695-016-2320-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11695-016-2320-z

Keywords

Search

Navigation