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Duodeno-Jejunal Tube Placement in an Experimental Model of Obesity: Effects on Food Behaviour and Basal Energy Expenditure

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Abstract

Background

Metabolic surgery can modulate weight as well as food intake and basal energy expenditure. In this study, we evaluate the effectiveness of duodenal exclusion by analysing anthropometric results, intake variations, food behaviour and calorimetric parameters.

Methods

This is an experimental study with 8-week-old Sprague-Dawley male rats. The sequences used are as follows: Cafeteria diet for 3 weeks, followed by surgery and sacrifice at 4 weeks. Four experimental groups are as follows: two non-obese groups (n = 15; surgery = 10, sham = 5) and two obese groups by cafeteria diet (n = 15; surgery = 10, sham = 5). Surgery performed was duodenal exclusion with physical barrier. Weight, intake, glycaemia and basal energy expenditure by indirect calorimetry were monitored before and after surgery.

Results

Weight changes in groups that underwent intervention were significant. The reduction in calorie consumption after surgery was significant in the obese intervention group despite an increased standard feed consumption (161 ± 11 vs 139 ± 13 Kcal/day, p < 0.05; due to a lower consumption of cafeteria diet). In non-obese animals, changes were transient. Basal energy expenditure decreased in both intervention groups: 6.2 ± 0.5 vs 5.5 ± 0.4 Kcal/kg/h in non-obese animals and 5.6 ± 0.3 vs 4.7 ± 0.3 Kcal/kg/h in obese animals (p < 0.05).

Conclusions

Duodeno-jejunal tube placement stops weight gain in obese and non-obese animals. In obese animals, there is an important qualitative change in appetite towards standard feed with a significant decrease in caloric intake. In non-obese animals, changes in quantitative intake are transient. This surgery decreases basal energy expenditure in obese animals. This may be attributed to an enhanced thermogenic effect of food and a slowing in the animal’s weight gain.

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Conflict of Interest

The authors (Sabench F, Vives M, Cabrera A, Hernández M, Feliu A, Blanco S, Molina A, Bertrán R, Joven J, Del Castillo D) declare that they have no conflict of interests to disclose.

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Authors and Affiliations

  1. Surgery Unit of the Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Tarragona, Spain

    Fàtima Sabench Pereferrer, Margarida Vives Espelta & Arantxa Cabrera Vilanova

  2. Sant Joan University Hospital, Reus, Tarragona, Spain

    Mercè Hernández González & Santiago Blanco Blasco

  3. Paediatric Endocrinology Service, Sant Joan University Hospital, Reus, Tarragona, Spain

    Albert Feliu Rovira

  4. Surgery Unit of the Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Tarragona, Spain

    Alicia Molina López & Daniel Del Castillo Déjardin

  5. Medicine Unit of the Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Tarragona, Spain

    Raul Beltrán Nebot

  6. Medicine Unit of the Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Tarragona, Spain

    Jorge Joven Maried

  7. Sant Joan University Hospital, C/Sant Joan S/N, 43202, Reus, Tarragona, Spain

    Daniel Del Castillo Déjardin

Authors
  1. Fàtima Sabench Pereferrer
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  2. Margarida Vives Espelta
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  3. Arantxa Cabrera Vilanova
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  4. Mercè Hernández González
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  5. Albert Feliu Rovira
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  6. Santiago Blanco Blasco
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  7. Alicia Molina López
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  8. Raul Beltrán Nebot
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  9. Jorge Joven Maried
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  10. Daniel Del Castillo Déjardin
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Corresponding author

Correspondence to Daniel Del Castillo Déjardin.

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Sabench Pereferrer, F., Vives Espelta, M., Cabrera Vilanova, A. et al. Duodeno-Jejunal Tube Placement in an Experimental Model of Obesity: Effects on Food Behaviour and Basal Energy Expenditure. OBES SURG 25, 55–63 (2015). https://doi.org/10.1007/s11695-014-1345-4

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  • DOI: https://doi.org/10.1007/s11695-014-1345-4

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