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The Kinetics of Vitamin D3 in the Osteoblastic Cell

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Abstract

Experimental evidence is presented on the translocation of vitamin D metabolite, 1,25-(OH)2D3, from the membrane to the nucleus in osteoblast progenitor cells. A mathematical model permitting traversal of the cytoplasm at either a fixed velocity or by diffusion is formulated in order to determine whether transport along the cytoskeletal tracks is more consistent with the observed spatial-temporal distribution than diffusion, and it is so found. The model includes reactions in the nucleus involving D3 to form other compounds, such as protegerin, and thus also makes predictions of the concentrations of these compounds in various regions of the cell.

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Notes

  1. It may be seen from Fig. 1 the Calcitrol has clearly entered the nucleus by 2 hours.

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Authors and Affiliations

  1. Mathematics Department, United States Naval Academy, Annapolis, MD, USA

    James L. Buchanan

  2. Department of Mathematical Sciences, University of Delaware, Newark, DE, USA

    Robert Gilbert & Yvonne Ou

  3. Biological Sciences, University of Delaware, Newark, DE, USA

    Anja Nohe & Rachel Schaefer

Authors
  1. James L. Buchanan
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  2. Robert Gilbert
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  3. Yvonne Ou
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  4. Anja Nohe
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  5. Rachel Schaefer
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Corresponding author

Correspondence to James L. Buchanan.

Additional information

Y. Ou’s work was funded in part by the National Science Foundation Research Math. Biology Grants DMS-0920850 and 0920852.

A. Nohe’s project was supported by grants from the National Center for Research Resources (5P30RR031160-03) and the National Institute of General Medical Sciences (8 P30 GM103519-03) from the National Institutes of Health.

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Buchanan, J.L., Gilbert, R., Ou, Y. et al. The Kinetics of Vitamin D3 in the Osteoblastic Cell. Bull Math Biol 75, 1612–1635 (2013). https://doi.org/10.1007/s11538-013-9861-2

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  • DOI: https://doi.org/10.1007/s11538-013-9861-2

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