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Advance of antithrombotic treatment in patients with cerebral microbleed

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Abstract

With the elder proportion increasing and the antithrombotic agents widely using as well as the newly magnetic resonance imaging sequence emerging, the detection rate of cerebral microbleed (CMB) is gradually raising in recent years. As we all know that CMB mainly reflects the severity of deeply small vessel lesions, which predicts hemorrhagic transformation. Whereby, to some patients with both CMB and remarkable antithrombotic indication, treatment becomes a dilemma. We have to face the challenge of weighing the pros and cons of both drug indication and bleeding risk when making a proper decision for patients. This study summarized recent advance on CMB diagnosis and treatment, to provide a useful reference to physicians in their clinical practice.

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Abbreviations

CMB:

Cerebral microbleed

MRI:

Magnetic resonance imaging

SWI:

Sensitivity-weighted image

T2*GRE:

T2* gradient echo

sICH:

Symptomatic intracranial hemorrhage

CAA:

Cerebral amyloid angiopathy

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Acknowledgements

We would like to thank all doctors who participated in this study for their cooperation.

Funding

This study was sponsored by the National Key R&D Program (2017YFC1308401), the National Natural Science Foundation (81371289, 81660209) and the Project of Beijing Municipal Top Talent of Healthy Work (2014-2-015) of China.

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Authors and Affiliations

  1. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China

    Zhiying Chen, Yuchuan Ding & Ran Meng

  2. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China

    Xunming Ji

  3. Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China

    Xunming Ji & Ran Meng

  4. Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, 48201, USA

    Yuchuan Ding

  5. Department of Neurology, Affiliated Hospital of Jiujiang University, Jiujiang, 332000, Jiangxi, China

    Zhiying Chen & Xiaoping Yin

Authors
  1. Zhiying Chen
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  2. Yuchuan Ding
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  3. Xunming Ji
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  4. Xiaoping Yin
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  5. Ran Meng
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Contributions

RM: manuscript drafting and revision, and study concept and design. ZC: manuscript drafting and revision, study concept and design, collection, assembly, and interpretation of the study.XY,YD and XJ: deeply edited the revised version and contributed critical revision.

Corresponding author

Correspondence to Ran Meng.

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Chen, Z., Ding, Y., Ji, X. et al. Advance of antithrombotic treatment in patients with cerebral microbleed. J Thromb Thrombolysis 51, 530–535 (2021). https://doi.org/10.1007/s11239-020-02213-5

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  • DOI: https://doi.org/10.1007/s11239-020-02213-5

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