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Auditory Event-Related P300 Potentials in Rheumatoid Arthritis Patients

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Neurophysiology Aims and scope

The aim of the study was to assess P300 event-related potentials (ERPs) in patients suffering from rheumatoid arthritis (RA) in relation to the duration of illness, degree of disease activity, anatomical and functional stage of the disease, pain intensity, and pain unpleasantness. The cross-sectional study included 53 women with RA (RA group; mean age 50.58 ± 0.93 years) and 27 healthy women (control group, C; 49.41 ± 1.08 years). The intensity and unpleasantness of pain were determined using a visual analog scale (VAS); the functional status was assessed using HAQ (Health Assessment Questionnaire), and the disease activity was estimated using the disease activity scale (DAS28). The P300 waves initiated by auditory stimulations according to the oddball paradigm were recorded from leads Fz and Cz. There were no significant differences between the P300 latencies in both leads. At the same time, the average P300 amplitudes in both leads were found to be considerably lower (P < 0.05) in the RA group compared to the C group. Thus, there is a statistically significant amplitude difference between the P300 cognitive ERPs in RA patients and control subjects.

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Authors and Affiliations

  1. Faculty of Medicine, University of Novi Sad, Clinical Center of Vojvodina, Clinic for Medical Rehabilitation, Novi Sad, Serbia

    S. Tomasevic-Todorovic, K. Boskovic, D. Filipovic & B. Milekic

  2. Faculty of Medicine, University of Belgrade, Clinic for Physical and Rehabilitation Medicine, Clinical Center of Serbia, Belgrade, Serbia

    M. Grajic

  3. School of Rural Health, Monash University, Melbourne, Australia

    F. Hanna

Authors
  1. S. Tomasevic-Todorovic
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  2. K. Boskovic
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  3. D. Filipovic
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  4. B. Milekic
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  5. M. Grajic
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  6. F. Hanna
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Correspondence to S. Tomasevic-Todorovic.

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Tomasevic-Todorovic, S., Boskovic, K., Filipovic, D. et al. Auditory Event-Related P300 Potentials in Rheumatoid Arthritis Patients. Neurophysiology 47, 138–143 (2015). https://doi.org/10.1007/s11062-015-9510-5

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