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5,10-Methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) gene polymorphisms and adult meningioma risk

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Abstract

The causes of meningiomas are not well understood. Folate metabolism gene polymorphisms have been shown to be associated with various human cancers. It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) and risk of adult meningioma. A population-based case–control study involving 600 meningioma patients (World Health Organization [WHO] Grade I, 391 cases; WHO Grade II, 167 cases; WHO Grade III, 42 cases) and 600 controls was done for the MTHFR C677T and A1298C, MTRR A66G, and MTR A2756G variants in Chinese Han population. The folate metabolism gene polymorphisms were determined by using a polymerase chain reaction–restriction fragment length polymorphism assay. Meningioma cases had a significantly lower frequency of MTHFR 677 TT genotype [odds ratio (OR) = 0.49, 95 % confidence interval (CI) 0.33–0.74; P = 0.001] and T allele (OR = 0.80, 95 % CI 0.67–0.95; P = 0.01) than controls. A significant association between risk of meningioma and MTRR 66 GG (OR = 1.41, 95 % CI 1.02–1.96; P = 0.04) was also observed. When stratifying by the WHO grade of meningioma, no association was found. Our study suggested that MTHFR C677T and MTRR A66G variants may affect the risk of adult meningioma in Chinese Han population.

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Acknowledgments

This study was supported by the grants from National Natural Science Foundation of China (81271914), Zhejiang Provincial Natural Science Foundation (LY12H16025), Science Foundation of Health Bureau of Zhejiang Province (2011KYA081), Science Foundation of Education Bureau of Zhejiang Province (Y201121182) and Funds for Key Program of the Science Technology Department Zhejiang Province (2012C13019-2).

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The authors declare that they have no conflict of interests.

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Authors and Affiliations

  1. Clinical Laboratory, Sir Run Run Show Hospital, School of Medicine, Zhejiang University, No. 3 QingChun East Road, Hangzhou, 310016, China

    Jun Zhang, Yan-Wen Zhou, Hua-Ping Shi, Yan-Zhong Wang, Gui-Ling Li, Hai-Tao Yu & Xin-You Xie

  2. Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, 310016, China

    Jun Zhang, Yan-Wen Zhou, Gui-Ling Li, Hai-Tao Yu & Xin-You Xie

  3. Hangzhou Red Cross Hospital, Hangzhou, 310003, China

    Hua-Ping Shi

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  1. Jun Zhang
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Zhang, J., Zhou, YW., Shi, HP. et al. 5,10-Methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) gene polymorphisms and adult meningioma risk. J Neurooncol 115, 233–239 (2013). https://doi.org/10.1007/s11060-013-1218-z

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