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Determination of thermodynamic interactions of poly(l-lactide) and biphasic calcium phosphate/poly(l-lactide) composite by inverse gas chromatography at infinite dilution

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Abstract

Inverse gas chromatography at infinite dilution was applied to determine the thermodynamic interactions of poly(l-lactide) (PLLA) and the composite of biphasic calcium phosphate and PLLA (BCP/PLLA). The specific retention volumes, \( V_{\text{g}}^{0} \), of 11 organic compounds of different chemical nature and polarity (non-polar, donor or acceptor) were determined in the temperature range of 308–378 K for PLLA and 308–398 K for BCP/PLLA. The weight fraction activity coefficients of test sorbates, \( \Omega_{1}^{\infty } \), and the Flory–Huggins interaction parameters, \( \chi_{12}^{\infty } \), were estimated and discussed in terms of interactions of the sorbates with PLLA and BCP/PLLA. Also, the partial molar free energy, \( \Delta G_{1}^{\infty } \), the partial molar heat of mixing, \( \Delta H_{1}^{\infty } \), the sorption molar free energy, \( \Delta G_{1}^{\text{S}} \), the sorption enthalpy, \( \Delta H_{1}^{\text{S}} \), and the sorption entropy, \( \Delta S_{1}^{\text{S}} \), were analyzed. A different chromatographic behavior of the two investigated samples, PLLA and BCP/PLLA, was observed. The values of \( \Omega_{1}^{\infty } \) indicated n-alkanes, diethyl ether, tetrahydrofurane (THF), cyclohexane, benzene, dioxane (except for 338 K), and ethyl acetate (EtAc) (except for 338 K) as non-solvents, and chloroform (CHCl3) as good solvent (except for 378 K) for PLLA. For BCP/PLLA, CHCl3, EtAc (for 378 K), dioxane (except for 378 K), and THF were indicated as good solvents.

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Acknowledgements

This work was funded by the Serbian Ministry of Education, Science and Technological Development through the projects III43009 and III45004. The authors thank Novartis Pharma AG (Basel, Switzerland) for their donation of the HP5890II gas chromatograph used in this work.

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Authors and Affiliations

  1. University of Belgrade, Institute for Chemistry, Technology and Metallurgy, Department of Chemistry, Njegoševa 12, 11001, Belgrade, Republic of Serbia

    Aleksandra B. Nastasović & Bojana M. Ekmeščić

  2. Centre for Fine Particles Processing and Nanotechnologies, Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, Knez Mihailova 35/4, 11000, Belgrade, Republic of Serbia

    Nenad L. Ignjatović & Dragan P. Uskoković

  3. University of Belgrade, Vinča Institute of Nuclear Sciences, Department of Chemical Dynamics and Permanent Education, P.O. Box 522, 11001, Belgrade, Republic of Serbia

    Dana D. Marković, Danijela D. Maksin & Antonije E. Onjia

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  1. Aleksandra B. Nastasović
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Correspondence to Aleksandra B. Nastasović.

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Nastasović, A.B., Ignjatović, N.L., Uskoković, D.P. et al. Determination of thermodynamic interactions of poly(l-lactide) and biphasic calcium phosphate/poly(l-lactide) composite by inverse gas chromatography at infinite dilution. J Mater Sci 49, 5076–5086 (2014). https://doi.org/10.1007/s10853-014-8214-3

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