Abstract
In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with unreacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate composites. The discovery of self-setting cements has opened up a new era in the medical application of calcium orthophosphates; several commercial formulations have already been introduced as a result. Many more compositions are in experimental stages. In this review, an insight into calcium orthophosphate cements, as excellent biomaterials suitable for both dental and bone grafting application, has been provided.
Similar content being viewed by others
Notes
In the vast majority cases, a precipitated poorly crystalline HA and CDHA are undistinguishable and might be considered as synonyms [11].
To honor Prof. George Jarvis Brush (1831–1912), an American mineralogist, Yale University, New Haven, Connecticut, USA [11].
Earlier, it was believed that DCPA and TTCP reacted upon mixing with water to form the stoichiometric HA [13–16]. However, further investigations have shown that only the first nuclei consist of a nearly stoichiometric HA, whereas further growth of these nuclei occurs in the form of CDHA [99]. Besides, there is a study demonstrating that the initially formed HA further interacts with remaining DCPD to form CDHA [100].
It is the time from which a cement no longer disintegrates when immersed in Ringer’s solution [87].
Water is omitted for simplicity. Therefore, dissolution of DCPA is written instead.
Ion-substituted ACPs contained other ions (carbonates, Mg, Zn, F) were used in that study [310].
References
Albee F, Morrison H (1920) Ann Surg 71:32
Haldeman K, Moore J (1934) Arch Surg 29:385
Ray R, Degge J, Gloyd P, Mooney G (1952) J Bone Joint Surg 34A:638
Getter L, Bhaskar S, Cutright D, Perez B, Brady J, Driskell T, O’Hara M (1972) J Oral Surg 30:263
Roy D, Linnehan S (1974) Nature 247:220
Koster K, Karbe E, Kramer H, Heide H, Konig R (1976) Langenbecks Arch Chir 341:77
Peelen J, Rejda B, Vermeiden J, de Groot K (1977) Sci Ceram 9:226
Jarcho M, Kay J, Gumaer K, Doremus R, Drobeck H (1977) J Bioeng 1:79
Jarcho M (1981) Clin Orthop 157:259
LeGeros RZ (1991) Calcium phosphates in oral biology and medicine. Karger, Basel
Dorozhkin SV (2007) J Mater Sci 42:1061. doi:https://doi.org/10.1007/s10853-006-1467-8
LeGeros RZ, Chohayeb A, Shulman A (1982) J Dent Res 61(Special issue):343
Brown WE, Chow LC (1983) J Dent Res 62(Special issue):672
Brown WE, Chow LC (1986) A new calcium phosphate water setting cement. In: Brown PW (ed) Cements research progress. American Ceramic Society, Westerville, p 352
Brown WE, Chow LC (1985) Dental restorative cement pastes. US Patent No. 4518430. May 21
Gruninger SE, Siew C, Chow LC, O’Young A, Ts’ao NK, Brown WE (1984) J Dent Res 63(Special issue):200
Tas AC, Aldinger F (2005) J Mater Sci Mater Med 16:167
Driskell TD, Heller AL, Koenigs JF (1975) Dental treatments. US Patent No. 3913229. October 21
Driessens FCM, Planell JA, Gil FJ (1995) In: Wise DL, Trantolo DJ, Altobelli DE, Yaszemski MJ, Gresser JD, Schwarz ER (eds) Encyclopedic handbook of biomaterials and bioengineering, Part B, applications, vol 2. Marcel Dekker, New York, p 855
Schmitz JP, Hollinger JO, Milan SB (1999) J Oral Maxillofac Surg 57:1122
Gbureck U, Barralet JE, Spatz K, Grover LM, Thull R (2004) Biomaterials 25:2187
Tagaya M, Goto H, Iinuma M, Wakamatsu N, Tamura Y, Doi Y (2005) Dent Mater J 24:555
Driessens FCM, Boltong MG, Khairoun I, De Maeyer EAP, Ginebra MP, Wenz R, Planell JA, Verbeeck RMH (2000) Applied aspects of calcium phosphate bone cement. In: Wise DL, Trantolo DJ, Lewandrowski KU, Gresser JD, Cattaneo MV (eds) Biomaterials engineering and devices: Human applications. vol. 2: Orthopaedic, dental and bone graft applications, Humana Press, Totowa, p 253
Driessens FCM, Planell JA, Boltong M, Khairoun I, Ginebra MP (1998) Proc Inst Mech Eng H: J Eng Med 212:427
Frankenburg EP, Goldstein SA, Bauer TW, Harris SA, Poser RD (1998) J Bone Joint Surg Am 80:1112
Frayssinet P, Gineste L, Conte P, Fages J, Rouquet N (1998) Biomaterials 19:971
Rey C, Tofighi A, Mounic S, Combes C, Lee D (2002) Biomimetism and calcium phosphate cements. In: Mainard D, Louis JP (eds) Actualités en Biomatériaux, vol 6. Editions Romillat, Paris, p 27
Combes C, Bareille R, Rey C (2006) J Biomed Mater Res A 79A:318
Bohner M, Gbureck U, Barralet JE (2005) Biomaterials 26:6423
Ginebra MP, Traykova T, Planell JA (2006) Biomaterials 27:2171
Ginebra MP, Traykova T, Planell JA (2006) J Control Release 113:102
Dreesmann H (1892) Beitr Klin Chir 9:804
Peltier LF (1961) Clin Orthop 21:1
Kelly CM, Wilkins RM, Gitelis S, Hartjen C, Watson JT, Kim PT (2001) Clin Orthop 382:42
Bohner M (2004) Biomaterials 25:741
Fernandez E, Vlad MD, Gel MM, Lopez J, Torres R, Cauich JV, Bohner M (2005) Biomaterials 26:3395
Nilsson M, Fernandez E, Sarda S, Lidgren L, Planell JA (2002) J Biomed Mater Res 61:600
Grover LM, Gbureck U, Wrightc AJ, Tremaynec M, Barralet JE (2006) Biomaterials 27:2178
Grover LM, Gbureck U, Wright AJ, Barralet JE (2005) J Amer Ceram Soc 88:3096
Grover LM, Gbureck U, Young AM, Wright AJ, Barralet JE (2005) J Mater Chem 46:4955
Lilley KJ, Gbureck U, Wright AJ, Knowles JC, Farrar DF, Barralet JE (2007) J Amer Ceram Soc 90:1892
Calafiori AR, di Marco G, Martino G, Marotta M (2007) J Mater Sci Mater Med 18:2331
Kon M, Hirakata LM, Miyamoto Y, Kasahara H, Asaoka K (2005) Dent Mater J 24:104
Serraj S, Michailesco P, Margerit J, Bernard B, Boudeville P (2002) J Mater Sci Mater Med 13:125
Nurit L, Margerit J, Terol A, Boudeville P (2002) J Mater Sci Mater Med 13:1007
Boudeville P, Serraj S, Leloup JM, Margerit J, Pauvert B, Terol A (1999) J Mater Sci Mater Med 10:99
Michaïlesco P, Kouassi M, Briak HE, Armynot A, Boudeville P (2005) J Biomed Mater Res Part B: Appl Biomater 74B:760
Briak HE, Durand D, Nurit J, Munier S, Pauvert B, Boudeville P (2002) J Biomed Mater Res (Appl Biomater) 63:447
El Briak H, Durand D, Boudeville P (2008) J Mater Sci Mater Med 19:737
Takagi S, Chow LC, Ishikawa K (1998) Biomaterials 19:1593
Yang Q, Troczynski T, Liu DM (2002) Biomaterials 23:2751
Roemhildt ML, McGee TD, Wagner SD (2003) J Mater Sci Mater Med 14:137
Roemhildt ML, Wagner SD, McGee TD (2006) J Mater Sci Mater Med 17:1127
Wang X, Ye J, Wang Y, Chen L (2007) J Biomed Mater Res Part B: Appl Biomater 82B:93
Huan Z, Chang J (2007) J Biomed Mater Res Part B: Appl Biomater 82B:352
Wang X, Ye J (2008) Variation of crystal structure of hydroxyapatite in calcium phosphate cement by the substitution of strontium ions. J Mater Sci Mater Med (early view)
Gbureck U, Knappe O, Grover LM, Barralet JE (2005) Biomaterials 26:6880
Driessens FCM, Boltong MG, de Mayer EAP, Wenz R, Nies B, Planell JA (2002) Biomaterials 23:4011
Gbureck U, Thull R, Barralet JE (2005) J Mater Sci Mater Med 16:423
Doi Y, Shimizu Y, Moriwaki Y, Aga M, Iwanaga H, Shibutani T, Yamamoto K, Iwayama Y (2001) Biomaterials 22:847
Lilley J, Gbureck U, Knowles JC, Farrar DF, Barralet JE (2005) J Mater Sci Mater Med 16:455
Ni GX, Lu WW, Tang B, Ngan AHW, Chiu KY, Cheung KMC, Li ZY, Luk KDK (2007) J Biomed Mater Res A 83A:570
Fadeeva IV, Barinov SM, Komlev VS, Fedotov DA, Durisin J, Medvecky L (2004) J Biomed Mater Res A 70A:303
Fernandez E, Vlad MD, Hamcerencu M, Darie A, Torres R, Lopez J (2005) J Mater Sci 40:3677. doi:https://doi.org/10.1007/s10853-005-0614-y
Locher FW (2006) Cement: principles of production and use, Duesseldorf. Verlag Bau + Technik GmbH, Germany
Burguera EF, Xu HHK, Weir MD (2006) J Biomed Mater Res Part B: Appl Biomater 77B:126
Burguera EF, Guitian F, Chow LC (2004) J Biomed Mater Res A 71A:275
Driessens FCM, Boltong MG, Bermudez O, Planell JA (1993) J Mater Sci Mater Med 4:503
Chow LC, Markovic M, Takagi S (1998) In: Struble LJ (ed) Cements research progress, chap 7. American Ceramic Society, Westerville, OH, pp 215–238
Driessens FCM, Boltong MG, Bermudez O, Planell JA, Ginebra MP, Fernández E (1994) J Mater Sci Mater Med 5:164
Kurashina K, Hirano M, Kotani A, Klein CPAT, de Groot K (1997) Biomaterials 18:539
Friedman CD, Costantino PD, Takagi S, Chow LC (1998) J Biomed Mater Res (Appl Biomater) 43:428
Khairoun I, Boltong MG, Driessens FCM, Planel JA (1997) Biomaterials 18:1535
Fernández E, Gil FJ, Best SM, Ginebra MP, Driessens FCM, Planell JA (1998) J Biomed Mater Res 41:560
Fukase Y, Eanes ED, Takagi S, Chow LC, Brown WE (1990) J Dent Res 69:1852
Xie L, Monroe EA (1991) Mater Res Soc Symp Proc 179:25
Ishikawa K, Miyamoto Y, Kon M, Nagayama M, Asaoka K (1995) Biomaterials 16:527
Xu HHK, Quinn JB, Takagi S, Chow LC (2002) J Dent Res 81:219
Lee YK, Lim BS, Kim CW (2003) J Oral Rehabil 30:418
Ginebra MP, Fernández E, de Mayer EAP, Verbeeck RM, Boltong MG, Ginebra J, Driessens FCM, Planell JA (1997) J Dent Res 76:905
Liu C, Shen W, Gu Y, Hu L (1997) J Biomed Mater Res 35:75
Driessens FCM, de Mayer EAP, Fernández E, Boltong MG, Berger G, Verbeeck RMH, Ginebra MP, Planell JA (1996) Bioceramics 9:231
Driessens FCM, Planell JA, Gil F (1995) Calcium phosphate bone cements. In: Wise DL, Trantolo DJ, Altobelli DE, Yaszemski MJ, Cresser JD, Schwartz ER (eds) Encyclopedic handbook of biomaterials and bioengineering, Part B, vol 2. Marcel Dekker, New York
Lemaitre J (1995) Inn Tech Biol Med 16:109
Xia Z, Grover LM, Huang Y, Adamopoulos IE, Gbureck U, Triffitt JT, Shelton RM, Barralet JE (2006) Biomaterials 27:4557
Bermudez O, Boltong MG, Driessens FCM, Planell JA (1994) J Mater Sci Mater Med 5:144
Khairoun I, Boltong MG, Driessens FCM, Planell JA (1998) J Mater Sci Mater Med 9:667
Lacout J, Mejdoubi E, Hamad M (1996) J Mater Sci Mater Med 7:371
Song Y, Feng Z, Wang T (2007) J Mater Sci Mater Med 18:1185
Liu C, Shao H, Chen F, Zheng H (2006) Biomaterials 27:5003
Sarda S, Fernandez E, Llorens J, Martinez S, Nilsson M, Planell JA (2001) J Mater Sci Mater Med 12:905
Weiss DD, Sachs MA, Woodard CR (2003) J Long Term Eff Med Implants 13:41
Brown WE, Chow LC (1986) A new calcium phosphate water-setting cement. In: Brown PW (ed) Cements research progress. American Ceramic Society, Westerville, p 351
Hatim Z, Freche M, Keribech A, Lacout JL (1998) Ann Chim Sci Mat 23:65
Ishikawa K, Asaoka K (1995) J Biomed Mater Res 29:1537
Chow LC (1991) J Ceram Soc Jpn 99:954
Chow LC (2000) Mat Res Soc Syrnp Proc 599:27
Chow LC (2001) Calcium phosphate cements. In: Chow LC, Eanes ED (eds) Octacalcium phosphate. Monographs in oral science, vol 18. Karger, Basel, p 148
Brown PW, Fulmer M (1991) J Amer Ceram Soc 74:934
TenHuisen KS, Brown PW (1994) J Dent Res 3:598
Ishikawa K, Takagi S, Chow LC, Suzuki K (1999) J Biomed Mater Res 46:504
Matsuya S, Takagi S, Chow LC (2000) J Mater Sci Mater Med 11:305
Lemaitre J, Mirtchi AA, Mortier A (1987) Silic Ind 9–10:141
Mirtchi AA, Lemaitre J, Terao N (1989) Biomaterials 10:475
Bohner M, Lemaitre J, Ring TA (1996) J Amer Ceram Soc 79:1427
Fernandez E, Gil FJ, Best SM, Ginebra MP, Driessens FCM, Planell JA (1998) J Biomed Mater Res 42:403
Fernandez E, Gil FJ, Ginebra MP, Driesens FCM, Planell JA, Best SM (1999) J Mater Sci Mater Med 10:223
Barralet JE, Lilley KJ, Grover LM, Farrar DF, Ansell C, Gbureck U (2004) Mater Sci Mater Med 15:407
Lilley KJ, Gbureck U, Wright AJ, Farrar DF, Barralet JE (2005) J Mater Sci Mater Med 16:1185
Wang X, Ye J, Wang Y, Wu X, Bai B (2007) J Biomed Mater Res A 81A:781
de Maeyer EAP, Verbeeck RMH, Vercruysse CWJ (2000) J Biomed Mater Res 52:95
Wang X, Ye J, Wang Y (2008) J Mater Sci Mater Med 19:813
Zoulgami M, Lucas A, Briard P, Gaudé J (2001) Biomaterials 22:1933
Knaack D, Goad ME, Aiolova M, Rey C, Tofighi A, Chakravarthy P, Lee DD (1998) J Biomed Mater Res 43:399
Monma H, Kanazawa T (1976) Yogyo-Kyokai-Shi 84:209
Fernandez E, Ginebra MP, Boltong MG, Driessens FCM, Ginebra J, De Maeyer EAP, Verbeeck RMH, Planell JA (1996) J Biomed Mater Res 32:367
Gbureck U, Barralet JE, Radu L, Klinger HG, Thull R (2004) J Amer Ceram Soc 87:1126
Bohner M. Malsy AK, Camire CL, Gbureck U (2006) Acta Biomater 2:343
Brunner TJ, Grass RN, Bohner M, Stark WJ (2007) J Mater Chem 38:4072
Alves HLR, dos Santos LA, Bergmann CP (2008) Injectability evaluation of tricalcium phosphate bone cement. J Mater Sci Mater Med (early view)
Gbureck U, Grolms O, Barralet JE, Grover LM, Thull R (2003) Biomaterials 24:4123
Gbureck U, Barralet JE, Hofmann MP, Thull R (2004) J Dent Res 83:425
Gbureck U, Barralet JE, Hofmann MP, Thull R (2004) J Amer Ceram Soc 87:311
Tsai CH, Ju CP, Lin JHC (2008) Morphology and mechanical behavior of TTCP-derived calcium phosphate cement subcutaneously implanted in rats. J Mater Sci Mater Med (early view)
Tsai CH, Lin RM, Ju CP, Lin JHC (2008) Biomaterials 29:984
Tsai CH, Lin JHC, Ju CP (2007) J Biomed Mater Res Part B: Appl Biomater 80B:244
Chow LC, Markovic M, Frukhtbeyn SA, Takagi S (2005) Biomaterials 26:393
TenHuisen KS, Brown PW (1998) Biomaterials 19:2209
Ginebra MP, Fernandez E, Driessens FCM, Planell JA (1999) J Amer Ceram Soc 82:2808
Durucan C, Brown PW (2000) J Mater Sci Mater Med 11:365
Durucan C, Brown PW (2002) J Amer Ceram Soc 85:2013
Ginebra MP, Driessens FCM, Planell JA (2004) Biomaterials 25:3453
Koshino T, Kubota W, Morii T (1995) Biomaterials 16:125
Liu C, Huang Y, Chen J (2004) J Biomed Mater Res Part B: Appl Biomater 69B:73
Liu C, Gai W, Pan S, Liu Z (2003) Biomaterials 24:2995
Charrière E, Terrazzoni S, Pittet C, Mordasini P, Dutoit M, Lemaitre J, Zysset P (2001) Biomaterials 22:2937
Bohner M (2000) Injury 31(Suppl. 4):S-D37
Bohner M (2001) Eur Spine J 10:S114
von Gonten AS, Kelly JR, Antonucci JM (2000) J Mater Sci Mater Med 11:95
Gisep A, Kugler S, Wahl D, Rahn B (2004) J Mater Sci Mater Med 15:1065
Bohner M (2007) J Mater Chem 38:3980
Ambard AJ, Mueninghoff L (2006) J Prosthodont 15:321
Lewis G (2006) J Biomed Mater Res B: Appl Biomater 76B:456
Kenny SM, Buggy M (2003) J Mater Sci Mater Med 14:923
Takagi S, Chow LC, Markovic M, Friedman CD, Costantino PD (2001) J Biomed Mater Res (Appl Biomater) 58:36
Standard test method for time of setting of hydraulic cement paste by Gillmore needles. ASTM C266–89. (1993) In: Annual book of ASTM standards, vol 04.01, Cement, lime, gypsum. American Society for Testing and Materials, Philadelphia, p 189
Standard test method for time of setting of hydraulic cement paste by Vicat needle. ASTM C191–92. (1993) In: Annual book of ASTM standards, vol 04.01, Cement, lime, gypsum. American Society for Testing and Materials, Philadelphia, p 158
Nilsson M, Carlson J, Fernandez E, Planell JA (2002) J Mater Sci Mater Med 13:1135
Hofmann MP, Nazhat SN, Gbureck U, Barralet JE (2006) J Biomed Mater Res Part B: Appl Biomater 79B:360
Martin RI, Brown PW (1997) Calcif Tissue Int 60:538
Brunner TJ, Bohner M, Dora C, Gerber C, Stark WJ (2007) J Biomed Mater Res B: Appl Biomater 83B:400
Gao WY, Wang YW, Dong LM, Yu ZW (2006) J Therm Anal Calorim 85:785
Bohner M, Gbureck U (2008) J Biomed Mater Res B: Appl Biomater 84B:375
Liu C, Huang Y, Zheng H (1999) J Amer Ceram Soc 82:1052
Hofmann MP, Young AM, Gbureck U, Nazhat SN Barralet JE (2006) J Mater Chem 16:3199
Ginebra MP, Fernandez E, Driessens FCM, Boltong MG, Muntasell J, Font J, Planell JA (1995) J Mater Sci Mater Med 6:857
Leung KS, Siu WS, Li SF, Qin L, Cheung WH, Tam KF, Po P, Lui Y (2006) J Biomed Mater Res Part B: Appl Biomater 78B:153
Baroud G, Matsushita C, Samara M, Beckman L, Steffen T (2004) J Biomed Mater Res B: Appl Biomater 68B:105
Constantz BR, Ison IC, Fulmer MT, Poser RD, Smith ST, van Wagoner M, Ross J, Goldstein SA, Jupiter JB, Rosenthal DI (1995) Science 267:1796
Nomoto T, Haraguchi K, Yamaguchi S, Sugano N, Nakayama H, Sekino T, Niihara K (2006) J Mater Sci Mater Med 17: 379
Barralet JE, Grover LM, Gbureck U (2004) Biomaterials 25:2197
Sarda S, Fernández E, Nilsson M, Balcells M, Planell JA (2002) J Biomed Mater Res 61:653
Bohner M, Baroud G (2005) Biomaterials 26:1553
Khairoun I, Boltong MG, Driessens FCM, Planell JA (1998) J Mater Sci Mater Med 9:425
Burguera EF, Xu HHK, Sun L (2008) J Biomed Mater Res B: Appl Biomater 84B:493
Ginebra MP, Rilliard A, Fernandez E, Elvira C, San Roman J, Planell JA (2001) J Biomed Mater Res 57:113
Bermudez O, Boltong MG, Driessens FCM, Planell JA (1993) J Mater Sci Mater Med 4:389
del Valle S, Miňo N, Muňoz F, González A, Planell JA, Ginebra MP (2007) J Mater Sci Mater Med 18:353
Khairoun I, Driessens FCM, Boltong MG, Planell JA, Wenz R (1999) Biomaterials 20:393
Miyamoto Y, Ishikawa K, Takechi M, Toh T, Yuasa T, Nagayama M, Suzuki K (1999) J Biomed Mater Res (Appl Biomater) 48:36
Bigi A, Bracci B, Panzavolta S (2004) Biomaterials 25:2893
Ishikawa K, Matsuya S, Nakagawa M, Udoh K, Suzuki K (2004) J Mater Sci Mater Med 15:13
Barralet JE, Hofmann M, Grover LM, Gbureck U (2003) Adv Mater 15:2091
Barralet JE, Duncan CO, Dover MS, Bassett DC, Nishikawa H, Monaghan A, Gbureck U (2005) J Biomed Mater Res Part B: Appl Biomater 73B:238
Wang X, Ye J, Wang Y (2007) Acta Biomater 3:757
Watanabe M, Tanaka M, Sakurai M, Maeda M (2006) J Eur Ceram Soc 26:549
Markovic M, Takagi S, Chow LC (2001) Key Eng Mater 192–195:773
Almirall A, Larrecq G, Delgado JA, Martínez S, Planell JA, Ginebra MP (2004) Biomaterials 25:3671
Barralet JE, Grover L, Gaunt T, Wright AJ, Gibson IR (2002) Biomaterials 23:3063
Takagi S, Chow LC (2001) J Mater Sci Mater Med 10:135
Simon CG Jr, Khatri CA, Wight SA, Wang FW (2002) J Orthop Res 20:473
Ruhe PQ, Hedberg EL, Padron NT, Spauwen PHM, Jansen JA, Mikos AG (2005) J Biomed Mater Res A 74A:533
Habraken WJ, Wolke JGC, Mikos AG, Jansen JA (2006) J Biomater Sci Polym Ed 17:1057
Link DP, van den Dolder J, van den Beucken JJJP, Cuijpers VM, Wolke JGC, Mikos AG, Jansen JA (2008) Evaluation of the biocompatibility of calcium phosphate cement/PLGA microparticle composites. J Biomed Mater Res A (early view)
Tas AC (2008) Preparation of porous apatite granules from calcium phosphate cement. J Mater Sci Mater Med (early view)
Habraken WJEM, de Jonge LT, Wolke JGC, Yubao L, Mikos AG, Jansen JA (2008) Introduction of gelatin microspheres into an injectable calcium phosphate cement. J Biomed Mater Res A (early view)
del Real RP, Wolke JGC, Vallet-Regi M, Jansen JA (2002) Biomaterials 23:3673
del Real RP, Ooms E, Wolke JGC, Vallet-Regi M, Jansen JA (2003) J Biomed Mater Res A 65A:30
Hesaraki S, Moztarzadeh F, Sharifi D (2007) J Biomed Mater Res A 83A:80
Hesaraki S, Moztarzadeh F, Solati-Hashjin M (2006) J Biomed Mater Res Part B: Appl Biomater 79B:203
Sarda S, Nilsson M, Balcells M, Fernández E (2003) J Biomed Mater Res A 65A:215
Friberg J, Fernández E, Sarda S, Nilsson M, Ginebra MP, Martinez S, Planell JA (2001) Key Eng Mater 192–195:777
Andrianjatovo H, Lemaître J (1995) Innov Tech Biol Med 16:140
Cherng A, Takagi S, Chow LC (1997) J Biomed Mater Res 35:273
Yokoyama A, Matsuno H, Yamamoto S, Kawasaki T, Kohgo T, Uo M, Watari F, Nakasu M (2003) J Biomed Mater Res A 64A:491
Xu HHK, Weir MD, Burguera EF, Fraser AM (2006) Biomaterials 27:4279
Bigi A, Torricelli P, Fini M, Bracci B, Panzavolta S, Sturba L, Giardino R (2004) Int J Artif Organs 27:664
Bigi A, Panzavolta S, Sturba L, Torricelli P, Fini M, Giardino R (2006) J Biomed Mater Res A 78A:739
Fujishiro Y, Takahashi K, Sato T (2001) J Biomed Mater Res 54:525
Bigi A, Panzavolta S, Rubini K (2004) Chem Mater 16:3740
Panzavolta S, Torricelli P, Sturba L, Bracci B, Giardino R, Bigi A (2008) J Biomed Mater Res A 84A:965
Majekodunmi AO, Deb S, Nicholson JW (2003) J Mater Sci Mater Med 14:747
Majekodunmi AO, Deb S (2007) J Mater Sci Mater Med 18:1883
Bohner M, Merkle HP, van Landuyt P, Trophardy G, Lemaitre J (2000) J Mater Sci Mater Med 11:111
Bohner M, Theiss F, Apelt D, Hirsiger W, Houriet R, Rizzoli G, Gnos E, Frei C, Auer JA, von Rechenberg B (2003) Biomaterials 24:3463
Barralet JE, Tremayne MJ, Lilley KJ, Gbureck U (2005) Chem Mater 17:1313
Driessens FCM, Boltong MG, de Maeyer EAP, Verbeeck RMH, Wenz R (2000) J Mater Sci Mater Med 11:453
Gbureck U, Dembski S, Thull R, Barralet JE (2005) Biomaterials 26:3691
Ishikawa K, Takagi S, Chow LC, Ishikawa Y (1995) J Mater Sci Mater Med 6:528
Miyamoto Y, Ishikawa K, Fukao K, Sawada M, Nagayama M, Kon M, Asaoka K (1995) Biomaterials 16:855
Fulmer MT, Brown PW (1993) J Biomed Mater Res 27:1095
Takechi M, Miyamoto Y, Momota Y, Yuasa T, Tatehara S, Nagayama M, Ishikawa K (2004) J Biomed Mater Res Part B: Appl Biomater 69B:58
Brown WE (1966) Clin Orthop Rel Res 44:205
Takechi M, Miyamoto Y, Ishikawa K, Toh T, Yuasa T, Nagayama M, Suzuki K (1998) Biomaterials 19:2057
Otsuka M, Matsuda Y, Suwa Y, Fox JL, Higuchi WI (1995) J Biomed Mater Res 29:25
Liu C, Shao H, Chen F, Zheng H (2003) Biomaterials 24:4103
Chen WC, Lin JHC, Ju CP (2003) J Biomed Mater Res 64:664
Fernandez E, Gil FJ, Ginebra MP, Driessens FCM, Planell JA, Best SM (1999) J Mater Sci Mater Med 10:177
Tung MS, Brown WE (1983) Calcif Tissue Int 35:783
Brown WE, Eidelman N, Tomazic BB (1987) Adv Dent Res 1:306
Bohner M, Lemaitre J, Ring T (1993) Hydraulic properties of tri-calcium orthophosphate—phosphoric acid—water mixtures. In: Duran P, Fernandez JF (eds) Third euro-ceramics. Castellon de la Plana. Faenza Editrice Iberica S.L., Spain
Bajpai P, Fuchs C, McCullum D (1987) Development of tricalcium orthophosphate ceramic cement. In: Lemons J (ed) Quantitative characterization and performance of porous implants for hard tissue applications, ASTM STP 953. American Society for Testing and Materials, Philadelphia, p 377
Bohner M, van Landuyt P, Merkle H, Lemaitre J (1997) J Mater Sci Mater Med 8:675
Constantz BR, Barr BM, Ison IC, Fulmer MT, Baker J, McKinney LA, Goodman SB, Gunasekaren S, Delaney DC, Ross J, Poser RD (1998) J Biomed Mater Res (Appl Biomater) 43:451
Elliott JC (1994) Structure and chemistry of the apatites and other calcium orthophosphates. Elsevier, Amsterdam
Vereecke G, Lemaitre J (1990) J Cryst Growth 104:820
Klein CP, de Groot K, Driessen AA, van der Lubbe HB (1985) Biomaterials 6:189
Apelt D, Theiss F, El-Warrak AO, Zlinszky K, Bettschart-Wolfisberger R, Bohner M, Matter S, Auer JA, von Rechenberg B (2004) Biomaterials 25:1439
Ikenaga M, Hardouin P, Lemaitre J, Andrianjatovo H, Flautre B (1998) J Biomed Mater Res 40:139
Grover LM, Knowles JC, Fleming GJP, Barralet JE (2003) Biomaterials 24:4133
Mariño FT, Mastio J, Rueda C, Blanco L, Cabarcos EL (2007) J Mater Sci Mater Med 18:1195
Mariño FT, Torres J, Hamdan M, Rodríguez CR, Cabarcos EL (2007) J Biomed Mater Res B Appl Biomater 83B:571
Flautre B, Delecourt C, Blary M, van Landuyt P, Lemaitre J, Hardouin P (1999) Bone 25:S35
Xie J, Riley C, Chittur K (2001) J Biomed Mater Res 57:357
Frayssinet P, Roudier M, Lerch A, Ceolin JL, Depres E, Rouquet N (2000) J Mater Sci Mater Med 11:811
Ohura K, Bohner M, Hardouin P, Lemaitre J, Pasquier G, Flautre B (1996) J Biomed Mater Res 30:193
Flautre B, Maynou C, Lemaitre J, van Landuyt P, Hardouin P (2002) J Biomed Mater Res (Appl Biomater) 63:413
Yuasa T, Miyamoto Y, Ishikawa K, Takechi M, Nagayama M, Suzuki K (2001) J Biomed Mater Res 54:344
Khairoun I, Magne D, Gauthier O, Bouler JM, Aguado E, Daculsi G, Weiss P (2002) J Biomed Mater Res 60:633
Bodde EWH, Cammaert CTR, Wolke JGC, Spauwen PHM, Jansen JA (2007) J Biomed Mater Res B: Appl Biomater 83B:161
Miyamoto Y, Ishikawa K, Takeshi M, Toh T, Yoshida Y, Nagayama M, Kon M, Asaoka K (1997) J Biomed Mater Res 37:457
Young S, Holde M, Gunasekaran S, Poser R, Constantz BR (1998) The correlation of radiographic, MRI, and histological evaluations over two years of a carbonated apatite cement in a rabbit model. In: Proceedings of the 44th Annual Meeting, Orthopaedic Research Society, New Orleans, USA, March 16–19, p 846
Kroese-Deutman HC, Wolke JGC, Spauwen PHM, Jansen JA (2006) J Biomed Mater Res A 79A:503
Bourgeois B, Laboux O, Obadia L, Gauthier O, Betti E, Aguado E, Daculsi G, Bouler JM (2003) J Biomed Mater Res A 65A:402
Wenisch S, Stahl JP, Horas U, Heiss C, Kilian O, Trinkaus K, Hild A, Schnettler R (2003) J Biomed Mater Res A 67A:713
Lu JX, Descamps M, Dejou J, Koubi G, Hardouin P, Lemaitre J, Proust JP (2002) J Biomed Mater Res (Appl Biomater) 63:408
Ooms EM, Wolke JG, van der Waerden JP, Jansen JA (2002) J Biomed Mater Res 61:9
Yuan H, Li Y, de Bruijn JD, de Groot K, Zhang X (2000) Biomaterials 21:1283
Theiss F, Apelt D, Brand B, Kutter A, Zlinszky K, Bohner M, Matter S, Frei C, Auer JA, von Rechenberg B (2005) Biomaterials 26:4383
Heymann D, Pradal G, Benahmad M (1999) Histol Histopathol 14:871
Dorozhkin SV (1999) Comment Inorg Chem 20:285
Dorozhkin SV (2002) Prog Cryst Growth Charact 44:45
Knabe C, Driessens FCM, Planell JA, Gildenhaar R, Berger G, Reif D, Fitzner R, Radlanski RJ, Gross U (2000) J Biomed Mater Res 52:498
Teitelbaum SL (2000) Science 289:1504
Mostov K, Werb Z (1997) Science 276:219
Rodan GA, Martin TJ (2000) Science 289:1508
Hench LL (1991) J Amer Ceram Soc 74:1487
Hench LL (1998) J Amer Ceram Soc 81:1705
Sun L, Berndt CC, Gross KA, Kucuk A (2001) J Biomed Mater Res B: Appl Biomater 58:570
Renault F, Chabriere E, Andrieu JP, Dublet B, Masson P, Rochu D (2006) J Chromatogr B 836:15
Yoshitake T, Kobayashi S, Ogawa T, Okuyama T (2006) Chromatography 27:19
Ooms EM, Egglezos EA, Wolke JGC, Jansen JA (2003) Biomaterials 24:749
Ooms EM, Wolke JGC, van de Heuvel MT, Jeschke B, Jansen JA (2003) Biomaterials 24:989
Kobayashi N, Ong K, Villarraga M, Schwardt J, Wenz R, Togawa D, Fujishiro T, Turner AS, Seim HB III, Bauer TW (2007) J Biomed Mater Res A 81A:838
Fernandez E, Ginebra MP, Bermudez O, Boltong MG, Driessens FCM, Planell JA (1995) J Mater Sci Lett 14:4
Yamamoto H, Niwa S, Hori M, Hattori T, Sawai K, Aoki S, Hirano M, Takeuchi H (1998) Biomaterials 19:1587
Andrianjatovo H, Jose F, Lemaitre J (1996) J Mater Sci Mater Med 7:34
Ishikawa K, Takagi S, Chow LC, Ishikawa Y, Eanes E, Asaoka K (1994) Dent Mater 10:26
Driessens FCM (1999) Chemistry and applied aspects of calcium orthophosphate bone cements. Concepts and clinical applications of ionic cements. September 8, Arcachon, France
Miyazaki K, Horibe T, Antonucci JM, Takagi S, Chow LC (1993) Dent Mater 9:41
Miyazaki K, Horibe T, Antonucci JM, Takagi S, Chow LC (1993) Dent Mater 9:46
dos Santos LA, de Oliveira LC, Rigo ECS, Carrodeguas RG, Boschi AO, de Arruda ACF (1999) Bone 25:99S
Mickiewicz RA, Mayes AM, Knaack D (2002) J Biomed Mater Res 61:581
Costantino PD, Friedman CD, Jones K, Chow LC, Sisson GA (1992) Plast Reconstr Surg 90:174
Chow LC, Hirayama S, Takagi S, Parry E (2000) J Biomed Mater Res (Appl Biomater) 53:511
Barralet JE, Gaunt T, Wright AJ, Gibson IR, Knowles JC (2002) J Biomed Mater Res (Appl Biomater) 63:1
Zhang Y, Xu HHK, Takagi S, Chow LC (2006) J Mater Sci Mater Med 17:437
Morgan EF, Yetkinler DN, Constantz BR, Dauskardt RH (1997) J Mater Sci Mater Med 8:559
Pittet C, Lemaitre J (2000) J Biomed Mater Res (Appl Biomater) 53:769
Xu HHK, Carey LE, Simon CG Jr (2007) J Mater Sci Mater Med 18:1345
Xu HHK, Simon CG Jr (2004) J Biomed Mater Res A 69A:267
Losee JE, Karmacharya J, Gannon FH, Slemp AE, Ong G, Hunenko O, Gorden AD, Bartlett SP, Kirschner RE (2003) J Craniofacial Surg 14:117
Khairoun I, LeGeros RZ, Daculsi G, Bouler JM, Gauthier O, Guicheux J (2005) Macroporous, resorbable and injectable calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment. Patent No. WO/2005/077049. August 25
Speirs AD, Oxland TR, Masri BA, Poursartip A, Duncan CP (2005) Biomaterials 26:7310
dos Santos LA, Carrodeguas RG, Boschi AO, de Arruda ACF (2003) J Biomed Mater Res A 65A:244
Gbureck U, Spatz K, Thull R (2003) Materialwissenschaft und Werkstofftechnik 34:1036
Zhang Y, Xu HHK (2005) J Biomed Mater Res A 75A:832
Buchanan F, Gallagher L, Jack V, Dunne N (2007) Proc Inst Mech Eng H: J Eng Med 221:203
Villacampa AI, Garca-Ruiz JM (2000) J Cryst Growth 211:111
Wang X, Ye J, Wang Y, Chen L (2007) J Amer Ceram Soc 90:962
Dickens-Venz SH, Takagi S, Chow LC, Bowen RL, Johnston AD, Dickens B (1994) Dent Mater 10:100
Xu HHK, Eichmiller FC, Barndt PR (2001) J Mater Sci Mater Med 12:57
Xu HHK, Quinn JB, Takagi S, Chow LC (2004) Biomaterials 25:1029
Sun L, Xu HHK, Takagi S, Chow LC (2007) J Biomater Appl 21:299
Pan ZH, Jiang PP, Fan QY, Ma B, Cai HP (2007) J Biomed Mater Res Part B: Appl Biomater 82B:246
Liu H, Li H, Cheng W, Yang Y, Zhu M, Zhou C (2006) Acta Biomater 2:557
Pan ZH, Cai HP, Jiang PP, Fan QY (2006) J Polymer Res 13:323
Weir MD, Xu HHK (2008) High-strength, in situ-setting calcium phosphate composite with protein release. J Biomed Mater Res A (early view)
Lin J, Zhang S, Chen T, Liu C, Lin S, Tian X (2006) J Biomed Mater Res Part B: Appl Biomater 76B:432
Miyamoto Y, Ishikawa K, Takechi M, Toh T, Yuasa T, Nagayama M, Suzuki K (1998) Biomaterials 19:707
Otsuka M, Kuninaga T, Otsuka K, Higuchi WI (2006) J Biomed Mater Res Part B: Appl Biomater 79B:176
Xu HHK, Eichmiller FC, Giuseppetti AA (2000) J Biomed Mater Res 52:107
Xu HHK, Quinn JB, Takagi S, Chow LC, Eichmiller FC (2001) J Biomed Mater Res 57:457
dos Santos LA, Carrodeguas RG, Boschi AO, de Arruda ACF (2003) Artif Organs 27:412
dos Santos LA, de Oliveira LC, da Silva Rigo EC, Carrodéguas RG, Boschi AO, de Arruda ACF (2000) Artif Organs 24:212
Xu HHK, Simon CG Jr (2004) J Orthop Res 22:535
Burguera EF, Xu HHK, Takagi S, Chow LC (2005) J Biomed Mater Res A 75A:966
Xu HHK, Quinn JB (2002) Biomaterials 23:193
Gorst NJS, Perrie Y, Gbureck U, Hutton AL, Hofmann MP, Grover LM, Barralet JE (2006) Acta Biomater 2:95
Julien M, Khairoun I, LeGeros RZ, Delplace S, Pilet P, Weiss P, Daculsi G, Bouler JM, Guicheux J (2007) Biomaterials 28:956
Lemaitre J, Munting E, Mirtchi AA (1992) Rev Stomatol Chir Maxillofac 93:163
Müller FA, Gbureck U, Kasuga T, Mizutani Y, Barralet JE, Lohbauer U (2007) J Amer Ceram Soc 90:3694
Gisep A, Wieling R, Bohner M, Matter S, Schneider E, Rahn B (2003) J Biomed Mater Res A 66A:532
Gbureck U, Spatz K, Thull R, Barralet JE (2005) J Biomed Mater Res Part B: Appl Biomater 73B:1
Castaldini A, Cavallini A (1985) Biomaterials 6:55
Sogal A, Hulbert SF (1992) Mechanical properties of a composite bone cement: polymethylmethacrylate and hydroxyapatite. Proceedings of the 5th international symposium on ceramics in medicine, Bioceramics, vol 5, p 213
Harper EJ, Behiri JC, Bonfield W (1995) J Mater Sci Mater Med 6:799
Harper EJ (1998) Proc Instn Mech Engrs Part H: J Engin Med 212:113
Shinzato S, Kobayashi M, Mousa WF, Kamimura M, Neo M, Kitamura Y, Kokubo T, Nakamura T (2000) J Biomed Mater Res 51:258
Harper EJ, Braden M, Bonfield W (2000) J Mater Sci Mater Med 11:491
Xu HHK, Quinn JB (2001) J Biomed Mater Res 57:165
Claes L, Höllen I, Ignatius A (1997) Orthopäde 26:459
Jansen JA, de Ruijter JE, Schaeken HG, van der Waerden JPC, Planell JA, Driessens FCM (1995) J Mater Sci Mater Med 6:653
Larsson S, Bauer TW (2002) Clin Orthop Relat Res 395:23
Gbureck U, Knappe O, Hofmann N, Barralet JE (2007) J Biomed Mater Res Part B: Appl Biomater 83B:132
Sethuraman S, Nair LS, El-Amin S, Nguyen MTN, Greish YE, Bender JD, Brown PW, Allcock HR, Laurencin CT (2007) J Biomed Mater Res A 82A:884
Link DP, van den Dolder J, Wolke JG, Jansen JA (2007) Tissue Eng 13:493
Oda H, Nakamura K, Matsushita T, Yamamoto S, Ishibashi H, Yamazaki T, Morimoto S (2006) J Orthop Sci 11:167
Braun C, Rahn B, Fulmer M, Steiner A, Gisep A (2006) J Biomed Mater Res Part B: Appl Biomater 79B:151
Costantino P, Friedman C, Jones K, Chow LC, Pelzer H, Sisson G (1991) Arch Otolaryngol Head Neck Surg 117:379
Hong YC, Wang JT, Hong CY, Brown WE, Chow CY (1991) J Biomed Mater Res 25:485
Sugawara A, Fujikawa K, Kusama K, Nishiyama M, Murai S, Takagi S, Chow LC (2002) J Biomed Mater Res 61:47
Fujikawa K, Sugawara A, Kusama K, Nishiyama M, Murai S, Takagi S, Chow LC (2002) Dent Mater J 21:296
Sugawara A, Chow LC, Takagi S, Chohayeb H (1990) J Endod 16:162
Noetzel J, Özer K, Reisshauer BH, Anil A, Rössler R, Neumann K, Kielbassa AM (2006) Clin Oral Invest 10:77
Zhang W, Walboomers XF, Jansen JA (2007) The formation of tertiary dentin after pulp capping with a calcium phosphate cement, loaded with PLGA microparticles containing TGF-β1. J Biomed Mater Res A (early view)
Comuzzi L, Ooms E, Jansen JA (2002) Clin Oral Implants Res 13:304
Shirakata Y, Oda S, Kinoshita A, Kikuchi S, Tsuchioka H, Ishikawa I (2002) J Periodontol 73:1043
Chaung HM, Hong CH, Chiang CP, Lin SK, Kuo YS, Lan WH, Hsieh CC (1996) J Formos Med Assoc 95:545
Sliindo ML, Costantino PD, Friedman CD, Chow LC (1993) Arch Otolaryngol Head Neck Surg 119:185
Bifano CA, Edgin WA, Colleton C, Bifano SL, Constantino PD (1998) Oral Surg 85:512
Friedman C, Costantino P, Jones K, Chow LC, Pelzer H, Sisson G (1991) Arch Otolaryngol Head Neck Surg 117:385
Sinikovic B, Kramer FJ, Swennen G, Lubbers HT, Dempf R (2007) Int J Oral Maxillofac Surg 36:54
Smartt JM, Karmacharya J, Gannon FH, Ong G, Jackson O, Bartlett SP, Poser RD, Kirschner RE (2005) Plast Reconstr Surg 115:1642
Reddi SP, Stevens MR, Kline SN, Villanueva P (1999) J Craniomaxillofac Trauma 5:7
Friedman CD, Costantino PD, Synderman CH, Chow LC, Takagi S (2000) Arch Facial Plast Surg 2:124
Liverneaux P (2005) A cadaveric study Eur J Orthop Surg Traumatol 15:1
Liverneaux P, Vernet P, Robert C, Diacono P (2006) Eur J Orthop Surg Traumatol 16:10
Thordarson D, Hedman T, Yetkinler D, Eskander E, Lawrence T, Poser R (1999) J Bone Joint Surg 81A:239
Stankewich C, Swiontkowski M, Tencer A, Yetkinler D, Poser R (1996) J Orthopaedic Res 14:786
Goodman S, Bauer T, Carter D, Casteleyn PP, Goldstein SA, Kyle RF, Larsson S, Stankewich CJ, Swiontkowski MF, Tencer AF, Yetkinler DN, Poser RD (1998) Clin Orthop Rel Res 348:42
Bai B, Jazrawi L, Kummer F, Spivak J (1999) Spine 24:1521
Horstmann WG, Verheyen CCPM, Leemans R (2003) Injury 34:141
Simpson D, Keating JF (2004) Injury 35:913
Welch RD, Zhang H, Bronson DG (2003) J Bone Joint Surg Am 85:222
Keating JF, Hajducka CL, Harper J (2003) J Bone Joint Surg Br 85:68
Moore D, Maitra R, Farjo L, Graziano G, Goldstein S (1997) Spine 22:1696
Mermelstein LE, McLain RF, Yerby SA (1998) Spine 23:664
Mermelstein L, Chow LC, Friedman C, Crisco J (1996) J Orthop Trauma 10:15
Liverneaux P, Khallouk R (2006) J Orthop Sci 11:289
Ooms EM, Wolke JGC, van der Waerden JPCM, Jansen JA (2003) J Biomed Mater Res Part B: Appl. Biomater 66B:447
Strauss EJ, Pahk B, Kummer FJ, Egol K (2007) J Orthop Trauma 21:295
Schildhauer TA, Bennett AP, Wright TM, Lane JM, O’Leary PF (1999) J Bone Joint Surg 17:67
Jansen J, Ooms E, Verdonschot N, Wolke J (2005) Orthop Clin North Am 36:89
Maestretti G, Cremer C, Otten P, Jakob RP (2007) Eur Spine J 16:601
Hisatome T, Yasunaga Y, Ikuta Y, Fujimoto Y (2002) J Biomed Mater Res 59:490
Lim TH, Brebach GT, Renner SM, Kim WJ, Kim JG, Lee RE, Andersson GB, An HS (2002) Spine 27:1297
Belkoff SM, Mathis JM, Jasper LE, Deramond H (2001) Spine 26:1542
Heini PF, Berlemann U, Kaufmann M, Lippuner K, Fankhauser C, van Landuyt P (2001) Eur Spine J 10:164
Tomita S, Kin A, Yazu M, Abe M (2003) J Orthop Sci 8:192
Libicher M, Hillmeier J, Liegibel U, Sommer U, Pyerin W, Vetter M, Meinzer HP, Grafe I, Meeder P, Nöldge G, Nawroth P, Kasperk C (2006) Osteoporos Int 17:1208
Otsuka M, Matsuda Y, Suwa Y, Fox JL, Higuchi WI (1994) J Pharm Sci 83:255
Yu D, Wong J, Matsuda Y, Fox JL, Higuchi WI, Otsuka M (1992) J Pharm Sci 81:529
Bohner M, Lemaitre J, van Landuyt P, Zambelli P, Merkle H, Gander B (1997) J Pharm Sci 86:565
Kisanuki O, Yajima H, Umeda T, Takakura Y (2007) J Orthop Sci 12:281
Otsuka M, Matsuda Y, Suwa Y, Fox JL, Higuchi WI (1994) J Pharm Sci 83:1565
Otsuka M, Matsuda Y, Suwa Y, Fox JL, Higuchi WI (1994) J Pharm Sci 83:611
Li DX, Fan HS, Zhu XD, Tan YF, Xiao WQ, Lu J, Xiao YM, Chen JY, Zhang XD (2007) J Mater Sci Mater Med 18:2225
Kamegai A, Shimamura N, Naitou K, Nagahara K, Kanematsu N, Mori M (1994) Biomed Mater Eng 4:291
Fei Z, Hu Y, Wu D, Wu H, Lu R, Bai J, Song H (2008) Preparation and property of a novel bone graft composite consisting of rhBMP-2 loaded PLGA microspheres and calcium phosphate cement. J Mater Sci Mater Med (early view)
Bodde EWH, Boerman OC, Russel FGM, Mikos AG, Spauwen PHM, Jansen JA (2008) The kinetic and biological activity of different loaded rhBMP-2 calcium phosphate cement implants in rats. J Biomed Mater Res A (early view)
Meraw SJ, Reeve CM, Lohse CM, Sioussat TM (2000) J Periodont 71:8
Sasaki T, Ishibashi Y, Katano H, Nagumo A, Toh S (2005) J Arthroplasty 20:1055
Blom EJ, Klein-Nulend J, Wolke JGC, van Waas MAJ, Driessens FCM, Burger EH (2002) J Biomed Mater Res 59:265
Blom EJ, Klein-Nulend J, Yin L, van Waas MAJ, Burger EH (2001) Clin Oral Implants Res 12:609
Link DP, van den Dolder J, van den Beucken JJ, Wolke JG, Mikos AG, Jansen JA (2008) Biomaterials 29:675
Ruhé PQ, Boerman OC, Russel FGM, Mikos AG, Spauwen PHM, Jansen JA (2006) J Mater Sci Mater Med 17:919
Kisanuki O, Yajima H, Umeda T, Takakura Y (2007) J Orthopaedic Sci 12:281
Blattert TR, Delling G, Weckbach A (2003) Eur Spine J 12:216
Sanchez-Sotelo J, Munuera L, Madero R (2000) J Bone Joint Surg Br 82:856
Lobenhoffer P, Gerich T, Witte F, Tscherne H (2002) J Orthop Trauma 16:143
Cassidy C, Jupiter JB, Cohen M, Delli-Santi M, Fennell C, Leinberry C, Husband J, Ladd A, Seitz WR, Constanz B (2003) J Bone Joint Surg Am 85:2127
Schmidt R, Cakir B, Mattes T, Wegener M, Puhl W, Richter M (2005) Spine J 14:466
Vlad MD, Torres R, López J, Barracó M, Moreno JA, Fernández E (2007) J Mater Sci Mater Med 18:347
Krebs J, Aebli N, Goss BG, Sugiyama S, Bardyn T, Boecken I, Leamy PJ, Ferguson SJ (2007) J Biomed Mater Res Part B: Appl Biomater 82B:526
Takagi S, Chow LC, Hirayama S, Sugawara A (2003) J Biomed Mater Res Part B: Appl Biomater 67B:689
Carey LE, Xu HHK, Simon CG Jr, Takagi S, Chow LC (2005) Biomaterials 26:5002
Xu HHK, Carey LE, Simon CG Jr, Takagi S, Chow LC (2007) Dental Mater 23:433
Lemaitre J, Pittet C, Brendlen D (2003) Pasty or liquid multiple constituent compositions for injectable calcium phosphate cements. International PCT application, WO 03/041753 A1, May 22
Chow LC (1988) Adv Dent Res 2:181
Bohner M (2001) Calcium phosphate emulsions: possible applications. In: Giannini S, Moroni A (eds) Bioceramics 13. Trans Tech Publications Ltd., Zurich, p 65
Troczynski T (2004) Nat Mater 3:13
Xu HHK, Burguera EF, Carey LE (2007) Biomaterials 28:3786
Xu HHK, Takagi S, Quinn JB, Chow LC (2004) J Biomed Mater Res A 68A:725
Tajima S, Kishi Y, Oda M, Maruta M, Matsuya S, Ishikawa K (2006) Dent Mater J 25:616
Weir MD, Xu HHK, Simon CG Jr (2006) J Biomed Mater Res A 77A:487
Xu JH, Tan WQ, Lin J (2007) Chinese J Biomed Eng 26:153
Niikura T, Tsujimoto K, Yoshiya S, Tadokoro K, Kurosaka M, Shiba R (2007) Orthopedics 30:320
Lode A, Wolf-Brandstetter C, Reinstorf A, Bernhardt A, König U, Pompe W, Gelinsky M (2007) J Biomed Mater Res A 81A:474
Yoshikawa M, Toda T (2004) J Europ Ceram Soc 24:521
Simon CG Jr, Guthrie WF, Wang FW (2004) J Biomed Mater Res A 68A:628
dos Santos LA, Carrodéguas RG, Rogero SO, Higa OZ, Boschi AO, de Arruda AC (2002) Biomaterials 23:2035
Baroud G, Steffen T (2005) Eur Spine J 14:474
Acknowledgements
I would like to thank Dr. Marc Bohner for pointing my attention to this subject and Dr. A. Cuneyt Tas for some valuable comments concerning the single-phase cements.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dorozhkin, S.V. Calcium orthophosphate cements for biomedical application. J Mater Sci 43, 3028–3057 (2008). https://doi.org/10.1007/s10853-008-2527-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10853-008-2527-z