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Normal Values of High-Resolution Manometry in Supine and Upright Positions in a Thai Population

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Abstract

Background

Although cut-off values used in high-resolution manometry (HRM) to diagnose esophageal motility disorders are based on representative samples of the US population and assume a supine position, differences in population and body positioning can reportedly affect results.

Aims

To establish normal HRM values for Thai people in both supine and upright positions.

Methods

Forty-one healthy subjects were recruited, each of whom underwent solid-state HRM with ten 5-mL swallows of water in both the supine and upright positions. Measuring parameters according to the Chicago classification criteria (CC v3.0) were included, for which the mean, median and 5th and 95th percentiles (PCTLs) were calculated.

Results

The results corresponded with the CC v3.0 criteria, except for the mean, and 5th PCTL of the distal contractile integral (DCI), which were lower for this population. In the upright position, the mean and median values for DCI, intrabolus pressure and integrated relaxation pressure were significantly decreased, whereas the length of the transitional zone was significantly increased. The limitations of this study include: (1) the relatively low number of participants, (2) the limited recruitment of participants only at Ramathibodi Hospital and (3) the limited recruitment of only young and middle-aged participants.

Conclusions

We established normal values for the HRM parameters in a representative sample of the Thai population. Our supine results still prove that the use of the CC v3.0 is preferable. HRM testing in patients measured in the upright position should be analyzed based on the normative values obtained from upright swallow studies.

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Acknowledgments

The authors wish to thank Dr. Thanomnual Hiranyatheb, PhD, Faculty of Arts, Chulalongkorn University, for her kind assistance in revising the manuscript.

Funding

This research was supported by the Faculty of Medicine, Ramathibodi Hospital, Mahidol University.

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Authors and Affiliations

  1. Division of General Surgery, Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchatewe, Bangkok, 10400, Thailand

    Pitichote Hiranyatheb, Suriya Chakkaphak & Pattaraporn Lekhaka

  2. Division of Gastroenterology and Tropical Medicine, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

    Supphamat Chirnaksorn

  3. Endoscopic and Manometry Laboratory Unit, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

    Pitichote Hiranyatheb, Suriya Chakkaphak, Supphamat Chirnaksorn & Kaimuk Petsrikun

  4. Surgical Research Unit, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

    Kornkanok Somboonpun

Authors
  1. Pitichote Hiranyatheb
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  2. Suriya Chakkaphak
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Correspondence to Pitichote Hiranyatheb.

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Hiranyatheb, P., Chakkaphak, S., Chirnaksorn, S. et al. Normal Values of High-Resolution Manometry in Supine and Upright Positions in a Thai Population. Dig Dis Sci 63, 173–183 (2018). https://doi.org/10.1007/s10620-017-4838-x

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  • DOI: https://doi.org/10.1007/s10620-017-4838-x

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