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Diabetes and cancer I: risk, survival, and implications for screening

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Abstract

Type 2 diabetes mellitus (DM) and cancer are common diseases that are frequently diagnosed in the same individual. An association between the two conditions has long been postulated. Here, we review the epidemiological evidence for increased risk of cancer, decreased cancer survival, and decreased rates of cancer screening in diabetic patients. The risk for several cancers, including cancers of the pancreas, liver, colorectum, breast, urinary tract, and endometrium, is increased in patients with DM. In a pooled risk analysis weighting published meta-analytic relative risk (RR) for individual cancer by differences in their incidence rates, we found a population RR of 0.97 (95 % CI, 0.75–1.25) in men and 1.29 (95 % CI, 1.16–1.44) in women. All meta-analyses showed an increased relative risk for cancer in diabetic men, except studies of prostate cancer, in which a protective effect was observed. The relationship between diabetes and cancer appears to be complex, and at present, a clear temporal relationship between the two conditions cannot be defined. DM also impacts negatively on cancer-related survival outcomes and cancer screening rates. The overwhelming evidence for lower cancer screening rates, increased incidence of certain cancers, and poorer prognosis after cancer diagnosis in diabetic patients dictates a need for improved cancer care in diabetic individuals through improved screening measures, development of risk assessment tools, and consideration of cancer prevention strategies in diabetic patients. Part two of this review focuses on the biological and pharmacological mechanisms that may account for the association between DM and cancer.

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References

  1. Chowdhury TA (2010) Diabetes and cancer. QJM 103(12):905–915

    Article  PubMed  CAS  Google Scholar 

  2. Vigneri P, Frasca F, Sciacca L, Pandini G, Vigneri R (2009) Diabetes and cancer. Endocr Relat Cancer 16(4):1103–1123

    Article  PubMed  CAS  Google Scholar 

  3. Adami HO, McLaughlin J, Ekbom A et al (1991) Cancer risk in patients with diabetes mellitus. Cancer Causes Control 2(5):307–314

    Article  PubMed  CAS  Google Scholar 

  4. Adami HO, Chow WH, Nyren O et al (1996) Excess risk of primary liver cancer in patients with diabetes mellitus. J Natl Cancer Inst 88(20):1472–1477

    Article  PubMed  CAS  Google Scholar 

  5. Alokail MS, Al-Daghri NM, Al-Attas OS, Hussain T (2009) Combined effects of obesity and type 2 diabetes contribute to increased breast cancer risk in premenopausal women. Cardiovasc Diabetol 8:33

    Article  PubMed  CAS  Google Scholar 

  6. Anderson KE, Anderson E, Mink PJ et al (2001) Diabetes and endometrial cancer in the Iowa women’s health study. Cancer Epidemiol Biomarkers Prev 10(6):611–616

    PubMed  CAS  Google Scholar 

  7. Atchison EA, Gridley G, Carreon JD, Leitzmann MF, McGlynn KA (2011) Risk of cancer in a large cohort of U.S. veterans with diabetes. Int J Cancer 128(3):635–643

    Article  PubMed  CAS  Google Scholar 

  8. Ben Q, Cai Q, Li Z et al (2011) The relationship between new-onset diabetes mellitus and pancreatic cancer risk: a case-control study. Eur J Cancer 47(2):248–254

    Article  PubMed  Google Scholar 

  9. Bonelli L, Aste H, Bovo P et al (2003) Exocrine pancreatic cancer, cigarette smoking, and diabetes mellitus: a case-control study in northern Italy. Pancreas 27(2):143–149

    Article  PubMed  Google Scholar 

  10. Campbell PT, Deka A, Jacobs EJ et al (2010) Prospective study reveals associations between colorectal cancer and type 2 diabetes mellitus or insulin use in men. Gastroenterology 139(4):1138–1146

    Article  PubMed  Google Scholar 

  11. Cetin M, Colak R, Bayram F, Altinbas M, Unal A, Kelestimur F (2002) High prevalence of diabetes in patients with pancreatic cancer in central Anatolia, Turkey. Diabetes Res Clin Pract 58(2):97–100

    Article  PubMed  Google Scholar 

  12. Chao C, Page JH (2008) Type 2 diabetes mellitus and risk of non-Hodgkin lymphoma: a systematic review and meta-analysis. Am J Epidemiol 168(5):471–480

    Article  PubMed  Google Scholar 

  13. Chari ST, Leibson CL, Rabe KG, Ransom J, de Andrade M, Petersen GM (2005) Probability of pancreatic cancer following diabetes: a population-based study. Gastroenterology 129(2):504–511

    PubMed  Google Scholar 

  14. Chari ST, Leibson CL, Rabe KG et al (2008) Pancreatic cancer-associated diabetes mellitus: prevalence and temporal association with diagnosis of cancer. Gastroenterology 134(1):95–101

    Article  PubMed  CAS  Google Scholar 

  15. Chen CQ, Fang LK, Cai SR et al (2010) Effects of diabetes mellitus on prognosis of the patients with colorectal cancer undergoing resection: a cohort study with 945 patients. Chin Med J (Engl) 123(21):3084–3088

    Google Scholar 

  16. Chow WH, Gridley G, Nyren O et al (1995) Risk of pancreatic cancer following diabetes mellitus: a nationwide cohort study in Sweden. J Natl Cancer Inst 87(12):930–931

    Article  PubMed  CAS  Google Scholar 

  17. DeMeo MT (2001) Pancreatic cancer and sugar diabetes. Nutr Rev 59(4):112–115

    PubMed  CAS  Google Scholar 

  18. El-Serag HB, Hampel H, Javadi F (2006) The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence. Clin Gastroenterol Hepatol 4(3):369–380

    Article  PubMed  Google Scholar 

  19. Everhart J, Wright D (1995) Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis. JAMA 273(20):1605–1609

    Article  PubMed  CAS  Google Scholar 

  20. Fisher WE (2001) Diabetes: risk factor for the development of pancreatic cancer or manifestation of the disease? World J Surg 25(4):503–508

    Article  PubMed  CAS  Google Scholar 

  21. Flood A, Strayer L, Schairer C, Schatzkin A (2010) Diabetes and risk of incident colorectal cancer in a prospective cohort of women. Cancer Causes Control 21(8):1277–1284

    Article  PubMed  Google Scholar 

  22. Friberg E, Orsini N, Mantzoros CS, Wolk A (2007) Diabetes mellitus and risk of endometrial cancer: a meta-analysis. Diabetologia 50(7):1365–1374

    Article  PubMed  CAS  Google Scholar 

  23. Friberg E, Mantzoros CS, Wolk A (2007) Diabetes and risk of endometrial cancer: a population-based prospective cohort study. Cancer Epidemiol Biomarkers Prev 16(2):276–280

    Article  PubMed  Google Scholar 

  24. Frye JN, Inder WJ, Dobbs BR, Frizelle FA (2000) Pancreatic cancer and diabetes: is there a relationship? A case-controlled study. Aust N Z J Surg 70(10):722–724

    Article  PubMed  CAS  Google Scholar 

  25. Fujino Y, Mizoue T, Tokui N, Yoshimura T (2001) Prospective study of diabetes mellitus and liver cancer in Japan. Diabetes Metab Res Rev 17(5):374–379

    Article  PubMed  CAS  Google Scholar 

  26. Gullo L, Pezzilli R, Morselli-Labate AM (1994) Diabetes and the risk of pancreatic cancer. N Engl J Med 331(2):81–84

    Article  PubMed  CAS  Google Scholar 

  27. Gullo L, Pezzilli R (2004) Diabetes and pancreatic cancer. Pancreas 28(4):451–452

    Article  PubMed  Google Scholar 

  28. Gupta S, Vittinghoff E, Bertenthal D et al (2006) New-onset diabetes and pancreatic cancer. Clin Gastroenterol Hepatol 4(11):1366–1372

    Article  PubMed  Google Scholar 

  29. Hassan MM, Curley SA, Li D et al (2010) Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma. Cancer 116(8):1938–1946

    Article  PubMed  Google Scholar 

  30. He J, Stram DO, Kolonel LN, Henderson BE, Le Marchand L, Haiman CA (2010) The association of diabetes with colorectal cancer risk: the multiethnic cohort. Br J Cancer 103(1):120–126

    Article  PubMed  CAS  Google Scholar 

  31. Hemminki K, Li X, Sundquist J, Sundquist K (2010) Risk of cancer following hospitalization for type 2 diabetes. Oncologist 15(6):548–555

    Article  PubMed  Google Scholar 

  32. Hjalgrim H, Frisch M, Ekbom A, Kyvik KO, Melbye M, Green A (1997) Cancer and diabetes–a follow-up study of two population-based cohorts of diabetic patients. J Intern Med 241(6):471–475

    Article  PubMed  CAS  Google Scholar 

  33. Hu FB, Manson JE, Liu S et al (1999) Prospective study of adult onset diabetes mellitus (type 2) and risk of colorectal cancer in women. J Natl Cancer Inst 91(6):542–547

    Article  PubMed  CAS  Google Scholar 

  34. Huxley R, Ansary-Moghaddam A, de González AB, Barzi F, Woodward M (2005) Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer 92(11):2076–2083

    Article  PubMed  CAS  Google Scholar 

  35. Inoue M, Iwasaki M, Otani T, Sasazuki S, Noda M, Tsugane S (2006) Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan. Arch Intern Med 166(17):1871–1877

    Article  PubMed  Google Scholar 

  36. Jamal MM, Yoon EJ, Vega KJ, Hashemzadeh M, Chang KJ (2009) Diabetes mellitus as a risk factor for gastrointestinal cancer among American veterans. World J Gastroenterol 15(42):5274–5278

    Article  PubMed  Google Scholar 

  37. Khan M, Mori M, Fujino Y et al (2006) Site-specific cancer risk due to diabetes mellitus history: evidence from the Japan collaborative cohort (JACC) study. Asian Pac J Cancer Prev 7(2):253–259

    PubMed  Google Scholar 

  38. Khaw KT, Wareham N, Bingham S, Luben R, Welch A, Day N (2004) Preliminary communication: glycated hemoglobin, diabetes, and incident colorectal cancer in men and women: a prospective analysis from the European prospective investigation into cancer-Norfolk study. Cancer Epidemiol Biomarkers Prev 13(6):915–919

    PubMed  Google Scholar 

  39. Kuang TT, Jin dY, Wang DS et al (2009) Clinical epidemiological analysis of the relationship between pancreatic cancer and diabetes mellitus: data from a single institution in China. J Dig Dis 10(1):26–29

    Article  PubMed  Google Scholar 

  40. Kuriki K, Tokudome S, Tajima K (2004) Association between type II diabetes and colon cancer among Japanese with reference to changes in food intake. Asian Pac J Cancer Prev 5(1):28–35

    PubMed  Google Scholar 

  41. Kuriki K, Hirose K, Tajima K (2007) Diabetes and cancer risk for all and specific sites among Japanese men and women. Eur J Cancer Prev 16(1):83–89

    Article  PubMed  Google Scholar 

  42. La Vecchia C, Negri E, Franceschi S, D’Avanzo B, Boyle P (1994) A case-control study of diabetes mellitus and cancer risk. Br J Cancer 70(5):950–953

    Article  PubMed  Google Scholar 

  43. La Vecchia C, Negri E, Decarli A, Franceschi S (1997) Diabetes mellitus and the risk of primary liver cancer. Int J Cancer 73(2):204–207

    Article  PubMed  Google Scholar 

  44. Larsson SC, Orsini N, Wolk A (2005) Diabetes mellitus and risk of colorectal cancer: a meta-analysis. J Natl Cancer Inst 97(22):1679–1687

    Article  PubMed  Google Scholar 

  45. Larsson SC, Mantzoros CS, Wolk A (2007) Diabetes mellitus and risk of breast cancer: a meta-analysis. Int J Cancer 121(4):856–862

    Article  PubMed  CAS  Google Scholar 

  46. Pannala R, Leirness JB, Bamlet WR, Basu A, Petersen GM, Chari ST (2008) Prevalence and clinical profile of pancreatic cancer-associated diabetes mellitus. Gastroenterology 134(4):81–987

    Article  CAS  Google Scholar 

  47. Vinikoor LC, Long MD, Keku TO, Martin CF, Galanko JA, Sandler RS (2009) The association between diabetes, insulin use, and colorectal cancer among Whites and African Americans. Cancer Epidemiol Biomarkers Prev 18(4):1239–1242

    Article  PubMed  CAS  Google Scholar 

  48. Wang F, Gupta S, Holly EA (2006) Diabetes mellitus and pancreatic cancer in a population-based case-control study in the San Francisco Bay Area. California. Cancer Epidemiol Biomarkers Prev 15(8):1458–1463

    Article  Google Scholar 

  49. Will JC, Galuska DA, Vinicor F, Calle EE (1998) Colorectal cancer: another complication of diabetes mellitus? Am J Epidemiol 147(9):816–825

    Article  PubMed  CAS  Google Scholar 

  50. Yalniz M, Pour PM (2005) Diabetes mellitus: a risk factor for pancreatic cancer? Langenbecks Arch Surg 390(1):66–72

    Article  PubMed  CAS  Google Scholar 

  51. La Vecchia C, Negri E, Decarli A, Franceschi S (1997) Diabetes mellitus and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 6(12):1007–1010

    PubMed  Google Scholar 

  52. Larsson SC, Permert J, Hakansson N, Naslund I, Bergkvist L, Wolk A (2005) Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to the risk of pancreatic cancer in two Swedish population-based cohorts. Br J Cancer 93(11):1310–1315

    Article  PubMed  CAS  Google Scholar 

  53. Larsson SC, Orsini N, Brismar K, Wolk A (2006) Diabetes mellitus and risk of bladder cancer: a meta-analysis. Diabetologia 49(12):2819–2823

    Article  PubMed  CAS  Google Scholar 

  54. Li CI, Daling JR, Tang MT, Malone KE (2011) Relationship between diabetes and risk of second primary contralateral breast cancer. Breast Cancer Res Treat 125(2):545–551

    Article  PubMed  Google Scholar 

  55. Li D, Tang H, Hassan MM, Holly EA, Bracci PM, Silverman DT (2011) Diabetes and risk of pancreatic cancer: a pooled analysis of three large case-control studies. Cancer Causes Control 22(2):189–197

    Article  PubMed  CAS  Google Scholar 

  56. Limburg PJ, Anderson KE, Johnson TW et al (2005) Diabetes mellitus and subsite-specific colorectal cancer risks in the Iowa women’s health study. Cancer Epidemiol Biomarkers Prev 14(1):133–137

    PubMed  Google Scholar 

  57. Limburg PJ, Vierkant RA, Fredericksen ZS et al (2006) Clinically confirmed type 2 diabetes mellitus and colorectal cancer risk: a population-based, retrospective cohort study. Am J Gastroenterol 101(8):1872–1879

    Article  PubMed  Google Scholar 

  58. Lindblad P, Chow WH, Chan J et al (1999) The role of diabetes mellitus in the aetiology of renal cell cancer. Diabetologia 42(1):107–112

    Article  PubMed  CAS  Google Scholar 

  59. Lindemann K, Vatten LJ, Ellstrom-Engh M, Eskild A (2008) Body mass, diabetes and smoking, and endometrial cancer risk: a follow-up study. Br J Cancer 98(9):1582–1585

    Article  PubMed  CAS  Google Scholar 

  60. Lipscombe LL, Goodwin PJ, Zinman B, McLaughlin JR, Hux JE (2006) Diabetes mellitus and breast cancer: a retrospective population-based cohort study. Breast Cancer Res Treat 98(3):349–356

    Article  PubMed  Google Scholar 

  61. Luo J, Iwasaki M, Inoue M et al (2007) Body mass index, physical activity and the risk of pancreatic cancer in relation to smoking status and history of diabetes: a large-scale population-based cohort study in Japan–the JPHC study. Cancer Causes Control 18(6):603–612

    Article  PubMed  Google Scholar 

  62. Mackenzie T, Zens MS, Ferrara A, Schned A, Karagas MR (2011) Diabetes and risk of bladder cancer: evidence from a case-control study in New England. Cancer 117(7):1552–1556

    Article  PubMed  Google Scholar 

  63. Mitri J, Castillo J, Pittas AG (2008) Diabetes and risk of Non-Hodgkin’s lymphoma: a meta-analysis of observational studies. Diabetes Care 31(12):2391–2397

    Article  PubMed  Google Scholar 

  64. Ng Y, Husain I, Waterfall N (2003) Diabetes mellitus and bladder cancer–an epidemiological relationship? Pathol Oncol Res 9(1):30–31

    Article  PubMed  Google Scholar 

  65. Noto H, Osame K, Sasazuki T, Noda M (2010) Substantially increased risk of cancer in patients with diabetes mellitus: a systematic review and meta-analysis of epidemiologic evidence in Japan. J Diabetes Complications 24(5):345–353

    Article  PubMed  Google Scholar 

  66. Ogunleye AA, Ogston SA, Morris AD, Evans JM (2009) A cohort study of the risk of cancer associated with type 2 diabetes. Br J Cancer 101(7):1199–1201

    Article  PubMed  CAS  Google Scholar 

  67. Parazzini F, La Vecchia C, Negri E et al (1999) Diabetes and endometrial cancer: an Italian case-control study. Int J Cancer 81(4):539–542

    Article  PubMed  CAS  Google Scholar 

  68. Ren HB, Yu T, Liu C, Li YQ (2011) Diabetes mellitus and increased risk of biliary tract cancer: systematic review and meta-analysis. Cancer Causes Control 22(6):837–847

    Article  PubMed  Google Scholar 

  69. Ren X, Zhang X, Zhang X et al (2009) Type 2 diabetes mellitus associated with increased risk for colorectal cancer: evidence from an international ecological study and population-based risk analysis in China. Public Health 123(8):540–544

    Article  PubMed  CAS  Google Scholar 

  70. Salazar-Martinez E, Lazcano-Ponce EC, Lira-Lira GG et al (2000) Case-control study of diabetes, obesity, physical activity and risk of endometrial cancer among Mexican women. Cancer Causes Control 11(8):707–711

    Article  PubMed  CAS  Google Scholar 

  71. Saltzman BS, Doherty JA, Hill DA et al (2008) Diabetes and endometrial cancer: an evaluation of the modifying effects of other known risk factors. Am J Epidemiol 167(5):607–614

    Article  PubMed  Google Scholar 

  72. Shu X, Ji J, Li X, Sundquist J, Sundquist K, Hemminki K (2010) Cancer risk among patients hospitalized for type 1 diabetes mellitus: a population-based cohort study in Sweden. Diabet Med 27(7):791–797

    Article  PubMed  CAS  Google Scholar 

  73. Wang C, Wang X, Gong G et al (2012) Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: A systematic review and meta-analysis of cohort studies. Int J Cancer 130(7):1639–1648

    Google Scholar 

  74. Washio M, Mori M, Khan M et al (2007) Diabetes mellitus and kidney cancer risk: the results of Japan collaborative cohort study for evaluation of cancer risk (JACC study). Int J Urol 14(5):393–397

    Article  PubMed  Google Scholar 

  75. Weiderpass E, Gridley G, Persson I, Nyren O, Ekbom A, Adami HO (1997) Risk of endometrial and breast cancer in patients with diabetes mellitus. Int J Cancer 71(3):360–363

    Article  PubMed  CAS  Google Scholar 

  76. Wu AH, Yu MC, Tseng CC, Stanczyk FZ, Pike MC (2007) Diabetes and risk of breast cancer in Asian-American women. Carcinogenesis 28(7):1561–1566

    Article  PubMed  CAS  Google Scholar 

  77. Yang YX, Hennessy S, Lewis JD (2005) Type 2 diabetes mellitus and the risk of colorectal cancer. Clin Gastroenterol Hepatol 3(6):587–594

    Article  PubMed  Google Scholar 

  78. Pannala R, Basu A, Petersen GM, Chari ST (2009) New-onset diabetes: a potential clue to the early diagnosis of pancreatic cancer. Lancet Oncol 10(1):88–95

    Article  PubMed  Google Scholar 

  79. Polednak AP (2007) Prevalence and predictors of comorbid diabetes among newly diagnosed Hispanic cancer patients in Connecticut. Cancer Detect Prev 31(6):453–456

    Article  PubMed  Google Scholar 

  80. Silverman DT, Schiffman M, Everhart J et al (1999) Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer. Br J Cancer 80(11):1830–1837

    Article  PubMed  CAS  Google Scholar 

  81. Swerdlow AJ, Laing SP, Qiao Z et al (2005) Cancer incidence and mortality in patients with insulin-treated diabetes: a UK cohort study. Br J Cancer 92(11):2070–2075

    Article  PubMed  CAS  Google Scholar 

  82. Wolf I, Sadetzki S, Catane R, Karasik A, Kaufman B (2005) Diabetes mellitus and breast cancer. Lancet Oncol 6(2):103–111

    Article  PubMed  CAS  Google Scholar 

  83. Bonovas S, Filioussi K, Tsantes A (2004) Diabetes mellitus and risk of prostate cancer: a meta-analysis. Diabetologia 47(6):1071–1078

    Article  PubMed  CAS  Google Scholar 

  84. Kasper JS, Giovannucci E (2006) A meta-analysis of diabetes mellitus and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 15(11):2056–2062

    Article  PubMed  Google Scholar 

  85. Haffner SM, Shaten J, Stem MP, Smith GD, Kuller L (1996) Low levels of sex hormone-binding globulin and testosterone predict the development of non-insulin-dependent diabetes mellitus in men. MRFIT Research Group. Multiple risk factor intervention trial. Am J Epidemiol 143(9):889–897

    Article  PubMed  CAS  Google Scholar 

  86. Gann PH, Hennekens CH, Ma J, Longcope C, Stampfer MJ (1996) Prospective study of sex hormone levels and risk of prostate cancer. J Natl Cancer Inst 88(16):1118–1126

    Article  PubMed  CAS  Google Scholar 

  87. Oxman AD, Guyatt GH (1991) Validation of an index of the quality of review articles. J Clin Epidemiol 44(11):1271–1278

    Article  PubMed  CAS  Google Scholar 

  88. Centers for Disease Control and Prevention National Program of Cancer Registries (2011) United States Cancer Statistics (2007) Cancer types grouped by race and ethnicity. Available at: http://www.cdc.gov/cancer/prostate/statistics/race.htm

  89. Cannata D, Fierz Y, Vijayakumar A, LeRoith D (2010) Type 2 diabetes and cancer: what is the connection? Mt Sinai J Med 77(2):197–213

    Article  PubMed  Google Scholar 

  90. Michels KB, Solomon CG, Hu FB et al (2003) Type 2 diabetes and subsequent incidence of breast cancer in the nurses’ health study. Diabetes Care 26(6):1752–1758

    Article  PubMed  Google Scholar 

  91. Johnson JA, Bowker SL, Richardson K, Marra CA (2011) Time-varying incidence of cancer after the onset of type 2 diabetes: evidence of potential detection bias. Diabetologia 54(9):2263–2271

    Article  PubMed  CAS  Google Scholar 

  92. Baradaran N, Ahmadi H, Salem S et al (2009) The protective effect of diabetes mellitus against prostate cancer: role of sex hormones. Prostate 69(16):1744–1750

    Article  PubMed  CAS  Google Scholar 

  93. Pierce BL, Plymate S, Ostrander EA, Stanford JL (2008) Diabetes mellitus and prostate cancer risk. Prostate 68(10):1126–1132

    Article  PubMed  Google Scholar 

  94. Tavani A, Gallus S, Bosetti C et al (2002) Diabetes and the risk of prostate cancer. Eur J Cancer Prev 11(2):125–128

    Article  PubMed  CAS  Google Scholar 

  95. Turner EL, Lane JA, Donovan JL et al (2011) Association of diabetes mellitus with prostate cancer: nested case-control study (Prostate testing for cancer and treatment study). Int J Cancer 128(2):440–446

    Article  PubMed  CAS  Google Scholar 

  96. Dormandy JA, Charbonnel B, Eckland DJ et al (2005) Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 366(9493):1279–1289

    Article  PubMed  CAS  Google Scholar 

  97. Patel A, MacMahon S, Chalmers J et al (2008) Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 358(24):2560–2572

    Article  PubMed  CAS  Google Scholar 

  98. Home PD, Pocock SJ, Beck-Nielsen H et al (2009) Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. Lancet 373(9681):2125–2135

    Article  PubMed  CAS  Google Scholar 

  99. Johnson JA, Bowker SL (2011) Intensive glycaemic control and cancer risk in type 2 diabetes: a meta-analysis of major trials. Diabetologia 54(1):25–31

    Article  PubMed  CAS  Google Scholar 

  100. Tsugawa K, Koyanagi N, Hashizume M et al (2002) Therapeutic strategy of emergency surgery for colon cancer in 71 patients over 70 years of age in Japan. Hepatogastroenterology 49(44):393–398

    PubMed  Google Scholar 

  101. Koperna T, Kisser M, Schulz F (1997) Emergency surgery for colon cancer in the aged. Arch Surg 132(9):1032–1037

    Article  PubMed  CAS  Google Scholar 

  102. Little SA, Jarnagin WR, DeMatteo RP, Blumgart LH, Fong Y (2002) Diabetes is associated with increased perioperative mortality but equivalent long-term outcome after hepatic resection for colorectal cancer. J Gastrointest Surg 6(1):88–94

    Article  PubMed  Google Scholar 

  103. Davila JA, Rabeneck L, Berger DH, El-Serag HB (2005) Postoperative 30-day mortality following surgical resection for colorectal cancer in veterans: changes in the right direction. Dig Dis Sci 50(9):1722–1728

    Article  PubMed  Google Scholar 

  104. Jullumstro E, Kollind M, Lydersen S, Edna TH (2009) Diabetes mellitus and outcomes of colorectal cancer. Acta Oncol 48(3):361–367

    Article  PubMed  Google Scholar 

  105. Abunasra H, Lewis S, Beggs L, Duffy J, Beggs D, Morgan E (2005) Predictors of operative death after oesophagectomy for carcinoma. Br J Surg 92(8):1029–1033

    Article  PubMed  CAS  Google Scholar 

  106. Bartels H, Stein HJ, Siewert JR (1998) Preoperative risk analysis and postoperative mortality of oesophagectomy for resectable oesophageal cancer. Br J Surg 85(6):840–844

    Article  PubMed  CAS  Google Scholar 

  107. Karl RC, Schreiber R, Boulware D, Baker S, Coppola D (2000) Factors affecting morbidity, mortality, and survival in patients undergoing Ivor Lewis esophagogastrectomy. Ann Surg 231(5):635–643

    Article  PubMed  CAS  Google Scholar 

  108. Wright CD, Kucharczuk JC, O’Brien SM, Grab JD, Allen MS (2009) Predictors of major morbidity and mortality after esophagectomy for esophageal cancer: a society of thoracic surgeons general thoracic surgery database risk adjustment model. J Thorac Cardiovasc Surg 137(3):587–596

    Article  PubMed  Google Scholar 

  109. Zhang GH, Fujita H, Yamana H, Kakegawa T (1994) A prediction of hospital mortality after surgical treatment for esophageal cancer. Surg Today 24(2):122–127

    Article  PubMed  CAS  Google Scholar 

  110. Chu CK, Mazo AE, Sarmiento JM et al (2010) Impact of diabetes mellitus on perioperative outcomes after resection for pancreatic adenocarcinoma. J Am Coll Surg 210(4):463–473

    Article  PubMed  Google Scholar 

  111. Duque JL, Ramos G, Castrodeza J et al (1997) Early complications in surgical treatment of lung cancer: a prospective, multicenter study. Grupo Cooperativo de Carcinoma Broncogénico de la Sociedad Española de Neumología y Cirugía Torácica. Ann Thorac Surg 63(4):944–950

    Article  PubMed  CAS  Google Scholar 

  112. Au J, el-Oakley R, Cameron EW (1994) Pneumonectomy for bronchogenic carcinoma in the elderly. Eur J Cardiothorac Surg 8(5):247–250

    Article  PubMed  CAS  Google Scholar 

  113. Dominguez-Ventura A, Allen MS, Cassivi SD, Nichols FC III, Deschamps C, Pairolero PC (2006) Lung cancer in octogenarians: factors affecting morbidity and mortality after pulmonary resection. Ann Thorac Surg 82(4):1175–1179

    Article  PubMed  Google Scholar 

  114. Romano PS, Mark DH (1992) Patient and hospital characteristics related to in-hospital mortality after lung cancer resection. Chest 101(5):1332–1337

    Article  PubMed  CAS  Google Scholar 

  115. Barone BB, Yeh HC, Snyder CF et al (2008) Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis. JAMA 300(23):2754–2764

    Article  PubMed  CAS  Google Scholar 

  116. Peairs KS, Barone BB, Snyder CF et al (2011) Diabetes mellitus and breast cancer outcomes: a systematic review and meta-analysis. J Clin Oncol 29(1):40–46

    Article  PubMed  Google Scholar 

  117. Snyder CF, Stein KB, Barone BB et al (2010) Does pre-existing diabetes affect prostate cancer prognosis? A systematic review. Prostate Cancer Prostatic Dis 13(1):58–64

    Article  PubMed  CAS  Google Scholar 

  118. Lam EK, Batty GD, Huxley RR et al (2011) Associations of diabetes mellitus with site-specific cancer mortality in the Asia-Pacific region. Ann Oncol 22(3):730–738

    Article  PubMed  CAS  Google Scholar 

  119. Landman GW, Ubink-Veltmaat LJ, Kleefstra N, Kollen BJ, Bilo HJ (2008) Increased cancer mortality in type 2 diabetes (ZODIAC-3). Anticancer Res 28(2B):1373–1375

    Google Scholar 

  120. Noto H, Tsujimoto T, Sasazuki T et al (2011) Significantly increased risk of cancer in patients with diabetes mellitus: a systematic review and meta-analysis. Endocr Pract 17(4):616–628

    Article  PubMed  Google Scholar 

  121. Zhou XH, Qiao Q, Zethelius B et al (2010) Diabetes, prediabetes and cancer mortality. Diabetologia 53(9):1867–1876

    Article  PubMed  CAS  Google Scholar 

  122. Seshasai SR, Kaptoge S, Thompson A et al (2011) Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med 364(9):829–841

    Article  PubMed  CAS  Google Scholar 

  123. (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UPDOS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352(9131):837–853

  124. (1998) Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352(9131):854–865

  125. Duckworth W, Abraira C, Moritz T et al (2009) Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 360(2):129–139

    Article  PubMed  CAS  Google Scholar 

  126. Gerstein HC, Miller ME, Byington RP et al (2008) Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 358(24):2545–2559

    Article  PubMed  CAS  Google Scholar 

  127. Jiralerspong S, Palla SL, Giordano SH et al (2009) Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol 27(20):3297–3302

    Article  PubMed  CAS  Google Scholar 

  128. Martin JH, Coory MD, Valery PC, Green AC (2009) Association of diabetes with survival among cohorts of Indigenous and non-Indigenous Australians with cancer. Cancer Causes Control 20(3):355–360

    Article  PubMed  Google Scholar 

  129. Giovannucci E, Harlan DM, Archer MC et al (2010) Diabetes and cancer: a consensus report. Diabetes Care 33(7):1674–1685

    Article  PubMed  Google Scholar 

  130. American Cancer Society Guidelines for the Early Detection of Cancer (2011) Available at: http://www.cancer.org/Healthy/FindCancerEarly/CancerScreeningGuidelines/american-cancer-society-guidelines-for-the-early-detection-of-cancer

  131. Beckman TJ, Cuddihy RM, Scheitel SM, Naessens JM, Killian JM, Pankratz VS (2001) Screening mammogram utilization in women with diabetes. Diabetes Care 24(12):2049–2053

    Article  PubMed  CAS  Google Scholar 

  132. Marshall JG, Cowell JM, Campbell ES, McNaughton DB (2010) Regional variations in cancer screening rates found in women with diabetes. Nurs Res 59(1):34–41

    Article  PubMed  Google Scholar 

  133. Zhao G, Ford ES, Ahluwalia IB, Li C, Mokdad AH (2009) Prevalence and trends of receipt of cancer screenings among US women with diagnosed diabetes. J Gen Intern Med 24(2):270–275

    Article  PubMed  Google Scholar 

  134. Ives DG, Lave JR, Traven ND, Schulz R, Kuller LH (1996) Mammography and pap smear use by older rural women. Public Health Rep 111(3):244–250

    PubMed  CAS  Google Scholar 

  135. McBean AM, Yu X (2007) The underuse of screening services among elderly women with diabetes. Diabetes Care 30(6):1466–1472

    Article  PubMed  Google Scholar 

  136. Karathanasi I, Kamposioras K, Cortinovis I et al (2009) Moving ahead in diabetics’ cancer screening; food for thought from the Hellenic experience. Eur J Cancer Care (Engl) 18(3):255–263

    Article  CAS  Google Scholar 

  137. Jimenez-Garcia R, Hernandez-Barrera V, Carrasco-Garrido P, Gil A (2009) Prevalence and predictors of breast and cervical cancer screening among Spanish women with diabetes. Diabetes Care 32(8):1470–1472

    Article  PubMed  CAS  Google Scholar 

  138. Lipscombe LL, Hux JE, Booth GL (2005) Reduced screening mammography among women with diabetes. Arch Intern Med 165(18):2090–2095

    Article  PubMed  Google Scholar 

  139. Bell RA, Shelton BJ, Paskett ED (2001) Colorectal cancer screening in North Carolina: associations with diabetes mellitus and demographic and health characteristics. Prev Med 32(2):163–167

    Article  PubMed  CAS  Google Scholar 

  140. Owens MD, Beckles GL, Ho KK, Gorrell P, Brady J, Kaftarian JS (2008) Women with diagnosed diabetes across the life stages: underuse of recommended preventive care services. J Womens Health (Larchmt) 17(9):1415–1423

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Hematology/Oncology, Marshfield Clinic Weston Center, 3501 Cranberry Boulevard, Weston, WI, 54476, USA

    Adedayo A. Onitilo

  2. Marshfield Clinic Research Foundation, Marshfield, WI, USA

    Adedayo A. Onitilo, Ingrid Glurich & Rachel V. Stankowski

  3. School of Population Health, University of Queensland, Brisbane, Australia

    Adedayo A. Onitilo, Gail M. Williams & Suhail A. Doi

  4. Department of Hematology/Oncology, Marshfield Clinic Cancer Care, Stevens Point, WI, USA

    Jessica M. Engel

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  1. Adedayo A. Onitilo
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  2. Jessica M. Engel
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Correspondence to Adedayo A. Onitilo.

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Onitilo, A.A., Engel, J.M., Glurich, I. et al. Diabetes and cancer I: risk, survival, and implications for screening. Cancer Causes Control 23, 967–981 (2012). https://doi.org/10.1007/s10552-012-9972-3

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