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Cortical Characterization and Inter-Dipole Distance Between Unilateral Median Versus Ulnar Nerve Stimulation of Both Hands in MEG

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Summary

Contralateral somatosensory evoked fields (SEF) by whole head MEG after unilateral median and ulnar nerve stimulation of both hands were studied in 10 healthy right-handed subjects. Major parameters describing cortical activity were examined to discriminate median and ulnar nerve evoked responses. Somatic sensitivity showed high similarity in the 4 study conditions for both hand and nerve. The brain SEFs consisted of 7–8 major peak stages with consistent responses in all subjects at M20, M30, M70 and M90. Comparable inter-hemispheric waveform profile but high inter-subject variability was found. Median nerve induced significantly shorter latencies in the early activities than those of the ulnar nerve. The 3D cortical maps in the post stimulus 450 ms timeframe showed for both nerves two polarity reversals, an early and a late one which is a new finding. Dipole characteristics showed differential sites for the M20 and M30 in the respective nerve. Higher dipole moments evoked by the median nerve were noticed when compared to the ulnar. Furthermore, the results of the dipole distances between both nerves for M20 were calculated to be at 11.17 mm ± 4.93 (LH) and 16.73 mm ± 5.66 (RH), respectively after right hand versus left hand stimulation. This study showed substantial differences in the cortical responses between median and ulnar nerve. Especially the dipole distance between median and ulnar nerve on the cortex was computed accurately for the first time in MEG. Little is known however of the cortical responses in chronic pain patients and the parameter(s) that may change in an individual patient or a group. These results provide precise basis for further evaluating cortical changes in functional disorders and disease sequelae related to median and ulnar nerves.

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Authors and Affiliations

  1. Department of Anesthesiology, Alkmaar Medical Center, Alkmaar, The Netherlands

    Peter J. Theuvenet

  2. MEG Center, VU University Hospital, Amsterdam, The Netherlands

    Bob W. van Dijk

  3. Low Temperature Division, Twente Technical University, Twente, The Netherlands

    Maria J. Peters

  4. Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands

    Jan M. van Ree

  5. BioMedical Institute, Amsterdam University, Amsterdam, The Netherlands

    Fernando L. Lopes da Silva

  6. Center for Higher Brain Functions, Capital University of Medical Sciences, Beijing, China

    Andrew C. N. Chen

  7. Oranjelaan 61, 1815 JR, Alkmaar, The Netherlands

    Peter J. Theuvenet

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Theuvenet, P.J., van Dijk, B.W., Peters, M.J. et al. Cortical Characterization and Inter-Dipole Distance Between Unilateral Median Versus Ulnar Nerve Stimulation of Both Hands in MEG. Brain Topogr 19, 29–42 (2006). https://doi.org/10.1007/s10548-006-0010-1

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