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Adrenergic α2A receptor gene and response to methylphenidate in attention-deficit/hyperactivity disorder-predominantly inattentive type

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Summary

An association between ADRA2A −1291 C > G polymorphism and response to methylphenidate in inattentive symptoms was previously suggested in children with ADHD. No investigation specifically assessed this association in ADHD–inattentive type (ADHD-I). In this naturalistic pharmacogenetic study, 59 subjects with ADHD-I from a non-referred sample were treated with short-acting methylphenidate and genotyped for ADRA2A −1291 C > G polymorphism. The primary outcome measure was the inattentive subscale of the SNAP-IV applied by a child psychiatrist blinded to genotype at baseline and first month of treatment. Children and adolescents with the G allele showed significantly lower inattentive scores with MPH treatment at the first month of treatment than subjects without the G allele (n = 59; F = 6.14; p = 0.016). We extended to ADHD-I previous findings suggesting the influence of the G allele at the ADRA2A −1291 C > G polymorphism on the improvement of inattentive symptoms with methylphenidate in children with all ADHD subtypes.

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Authors and Affiliations

  1. From the ADHD Outpatient Clinic, Child and Adolescent Psychiatric Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil

    T. L. da Silva, T. G. Pianca, M. Schmitz & L. A. Rohde

  2. Department of Morphological Sciences, Federal School of Medical Sciences of Porto Alegre, Rio Grande do Sul, Brazil

    T. Roman

  3. Department of Genetics, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil

    M. H. Hutz

  4. Department of Psychiatry, Upstate Medical University, Syracuse, NY, USA

    S. V. Faraone

Authors
  1. T. L. da Silva
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  2. T. G. Pianca
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  3. T. Roman
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  4. M. H. Hutz
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  5. S. V. Faraone
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  6. M. Schmitz
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  7. L. A. Rohde
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Correspondence to L. A. Rohde.

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Correspondence: Luis Augusto Rohde, Serviço de Psiquiatria da Infância e Adolescência, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, 4° andar – Porto Alegre, Rio Grande do Sul 90035-003, Brazil

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da Silva, T., Pianca, T., Roman, T. et al. Adrenergic α2A receptor gene and response to methylphenidate in attention-deficit/hyperactivity disorder-predominantly inattentive type. J Neural Transm 115, 341–345 (2008). https://doi.org/10.1007/s00702-007-0835-0

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  • DOI: https://doi.org/10.1007/s00702-007-0835-0

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