Summary
Blepharospasm and hemifacial spasm are the two most common craniofacial movement disorders. Blepharospasm is a syndrome characterized by excessive or continuous eye closure related to overactivity of the orbicularis oculi and adjacent muscles bilaterally. Hemifacial spasm is a peripherally-induced movement disorder typically caused by vascular compression of cranial nerve VII (CN VII) leading to involuntary unilateral contractions of muscles used in facial expression. Treatment options for both conditions include medications, botulinum toxin, and various surgical interventions. This article summarizes the existing medical literature which indicates that botulinum toxin is the treatment of choice for blepharospasm and hemifacial spasm.
Similar content being viewed by others
References
A Albanese AR Bentivoglio C Colosimo G Galardi L Maderna P Tonali (1996) ArticleTitlePretarsal injections of botulinum toxin improve blepharospasm in previously unresponsive patients J Neurol Neurosurg Psychiatry 60 693–694 Occurrence Handle8648343 Occurrence Handle1:STN:280:DyaK283ksFGjsA%3D%3D
R Astarloa B Morales V Sanchez N Penafiel J Rabano J Olivan J Garcia de Yebenes (1991) ArticleTitleFocal dystonias and facial hemispasm: treatment with botulinum A toxin Arch Neurobiol (Madr) 54 210–217 Occurrence Handle1:STN:280:DyaK383gs12lsw%3D%3D
RG Auger DG Piepgras ER Laws SuffixJr (1986) ArticleTitleHemifacial spasm: results of microvascular decompression of the facial nerve in 54 patients Mayo Clin Proc 61 640–644 Occurrence Handle3724243 Occurrence Handle1:STN:280:DyaL283lsFOhtQ%3D%3D
RG Auger JP Whisnant (1990) ArticleTitleHemifacial spasm in Rochester and Olmsted County, Minnesota, 1960 to 1984 Arch Neurol 47 1233–1234 Occurrence Handle2241620 Occurrence Handle1:STN:280:DyaK3M%2FltlyhtQ%3D%3D
GJ Ben Simon JD McCann (2005) ArticleTitleBenign essential blepharospasm Int Ophthalmol Clin 45 49–75 Occurrence Handle15970766 Occurrence Handle10.1097/01.iio.0000167238.26526.a8
A Berardelli A Carta F Stocchi A Formica A Agnoli M Manfredi (1990) ArticleTitleBotulinum A toxin injection in patients with blepharospasm, torticollis and hemifacial spasm Ital J Neurol Sci 11 589–593 Occurrence Handle2081684 Occurrence Handle10.1007/BF02337443 Occurrence Handle1:STN:280:DyaK3M7osFSisg%3D%3D
R Cakmur V Ozturk F Uzunel B Donmez F Idiman (2002) ArticleTitleComparison of preseptal and pretarsal injections of botulinum toxin in the treatment of blepharospasm and hemifacial spasm J Neurol 249 64–68 Occurrence Handle11954870 Occurrence Handle10.1007/PL00007849 Occurrence Handle1:CAS:528:DC%2BD38XisVKktL4%3D
G Cossu A Mereu M Deriu M Melis A Molari G Melis L Minafra T Pisano C Cianchetti E Ortu G Sau I Aiello M Fresu MG Marrosu P Contu (2006) ArticleTitlePrevalence of primary blepharospasm in Sardinia, Italy: a service-based survey Mov Disord 21 2005–2008 Occurrence Handle16960861 Occurrence Handle10.1002/mds.21084
Costa J, Espirito-Santo C, Borges A, Ferreira JJ, Coelho M, Moore P, Sampaio C (2005a) Botulinum toxin type A therapy for blepharospasm. Cochrane Database Syst Rev: CD004900
Costa J, Espirito-Santo C, Borges A, Ferreira JJ, Coelho M, Moore P, Sampaio C (2005b) Botulinum toxin type A therapy for hemifacial spasm. Cochrane Database Syst Rev: CD004899
JJ Dutton JJ White MJ Richard (2006) ArticleTitleMyobloc for the treatment of benign essential blepharospasm in patients refractory to botox Ophthal Plast Reconstr Surg 22 173–177 Occurrence Handle16714924 Occurrence Handle10.1097/01.iop.0000217382.33972.c4
JS Elston (1986) ArticleTitleBotulinum toxin treatment of hemifacial spasm J Neurol Neurosurg Psychiatry 49 827–829 Occurrence Handle3746313 Occurrence Handle1:STN:280:DyaL28zgs1ygsA%3D%3D
S Fahn T List C Moslowitz M Brin SB Bressman RE Burke A Scott (1985) ArticleTitleDouble-blind controlled study of botulinum toxin for blepharospasm Neurology 35 IssueIDSuppl 1 271–272
BR Frueh CC Nelson JF Kapustiak DC Musch (1988) ArticleTitleThe effect of omitting botulinum toxin from the lower eyelid in blepharospasm treatment Am J Ophthalmol 106 45–47 Occurrence Handle3394768 Occurrence Handle10.1016/0002-9394(88)90610-1 Occurrence Handle1:STN:280:DyaL1c3nvFKgug%3D%3D
N Galvez-Jimenez MR Hanson M Desai (2001) ArticleTitleUnusual causes of hemifacial spasm Semin Neurol 21 75–83 Occurrence Handle11346028 Occurrence Handle10.1055/s-2001-13122 Occurrence Handle1:STN:280:DC%2BD3M3ltVWmsQ%3D%3D
F Grandas J Elston N Quinn CD Marsden (1988) ArticleTitleBlepharospasm: a review of 264 patients J Neurol Neurosurg Psychiatry 51 767–772 Occurrence Handle3404184 Occurrence Handle1:STN:280:DyaL1czgtVSqsQ%3D%3D
H Iwashige Y Nemeto H Takahashi T Maruo (1995) ArticleTitleBotulinum toxin type A purified neurotoxin complex for the treatment of blepharospasm: a dose-response study measuring eyelid force Jpn J Ophthalmol 39 424–431 Occurrence Handle8926651 Occurrence Handle1:STN:280:DyaK283ksV2nsQ%3D%3D
J Jankovic (1995) ArticleTitleApraxia of lid opening Mov Disord 10 686–687 Occurrence Handle8552131 Occurrence Handle1:STN:280:DyaK28%2FmsVemsA%3D%3D
J Jankovic (1996) ArticleTitlePretarsal injection of botulinum toxin for blepharospasm and apraxia of eyelid opening J Neurol Neurosurg Psychiatry 60 704 Occurrence Handle8648354 Occurrence Handle1:STN:280:DyaK283ksFGisQ%3D%3D Occurrence Handle10.1136/jnnp.60.6.704
J Jankovic J Orman (1987) ArticleTitleBotulinum A toxin for cranial-cervical dystonia: a double-blind, placebo-controlled study Neurology 37 616–623 Occurrence Handle3561773 Occurrence Handle1:STN:280:DyaL2s7ntlGlsA%3D%3D
J Jankovic K Schwartz DT Donovan (1990) ArticleTitleBotulinum toxin treatment of cranial-cervical dystonia, spasmodic dysphonia, other focal dystonias and hemifacial spasm J Neurol Neurosurg Psychiatry 53 633–639 Occurrence Handle2213039 Occurrence Handle1:STN:280:DyaK3M%2FhtFCnsg%3D%3D
J Jankovic KD Vuong J Ahsan (2003) ArticleTitleComparison of efficacy and immunogenicity of original versus current botulinum toxin in cervical dystonia Neurology 60 1186–1188 Occurrence Handle12682332 Occurrence Handle1:STN:280:DC%2BD3s7msFSgtw%3D%3D
S Jitpimolmard S Tiamkao M Laopaiboon (1998) ArticleTitleLong term results of botulinum toxin type A (Dysport) in the treatment of hemifacial spasm: a report of 175 cases J Neurol Neurosurg Psychiatry 64 751–757 Occurrence Handle9647304 Occurrence Handle1:STN:280:DyaK1czgvFGiuw%3D%3D
WH Jost A Kohl (2001) ArticleTitleBotulinum toxin: evidence-based medicine criteria in blepharospasm and hemifacial spasm J Neurol 248 IssueIDSuppl 1 21–24 Occurrence Handle11357234 Occurrence Handle10.1007/PL00007813 Occurrence Handle1:CAS:528:DC%2BD3MXosVenur4%3D
L Kowal (1997) ArticleTitlePretarsal injections of botulinum toxin improve blepharospasm in previously unresponsive patients J Neurol Neurosurg Psychiatry 63 556 Occurrence Handle9343154 Occurrence Handle1:STN:280:DyaK1c%2FgtFeiuw%3D%3D
RL Levy D Berman M Parikh NR Miller (2006) ArticleTitleSupramaximal doses of botulinum toxin for refractory blepharospasm Ophthalmology 113 1665–1668 Occurrence Handle16828511 Occurrence Handle10.1016/j.ophtha.2006.03.055
JD Loeser J Chen (1983) ArticleTitleHemifacial spasm: treatment by microsurgical facial nerve decompression Neurosurgery 13 141–146 Occurrence Handle6888693 Occurrence Handle10.1097/00006123-198308000-00006 Occurrence Handle1:STN:280:DyaL3s3pvVShsA%3D%3D
K MacAndie E Kemp (2004) ArticleTitleImpact on quality of life of botulinum toxin treatments for essential blepharospasm Orbit 23 207–210 Occurrence Handle15590520 Occurrence Handle10.1080/01676830490506041
JA Mauriello SuffixJr R Keswani M Franklin (1999) ArticleTitleLong-term enhancement of botulinum toxin injections by upper-eyelid surgery in 14 patients with facial dyskinesias Arch Otolaryngol Head Neck Surg 125 627–631 Occurrence Handle10367918
F Micheli MC Scorticati E Gatto G Cersosimo J Adi (1994) ArticleTitleFamilial hemifacial spasm Mov Disord 9 330–332 Occurrence Handle8041374 Occurrence Handle10.1002/mds.870090310 Occurrence Handle1:STN:280:DyaK2czhs1ajug%3D%3D
SA Novis JP De Mattos AL De Rosso (1995) ArticleTitleBotulinum toxin in blepharospasm, in hemifacial spasm, and in cervical dystonia: results in 33 patients Arq Neuropsiquiatr 53 403–410 Occurrence Handle8540813 Occurrence Handle1:STN:280:DyaK28%2FosFGqsg%3D%3D
JG Nutt MD Muenter A Aronson LT Kurland LJ Melton Suffix3rd (1988) ArticleTitleEpidemiology of focal and generalized dystonia in Rochester, Minnesota Mov Disord 3 188–194 Occurrence Handle3264051 Occurrence Handle10.1002/mds.870030302 Occurrence Handle1:STN:280:DyaL1M%2Fls12rug%3D%3D
AL Pang J O’Day (2006) ArticleTitleUse of high-dose botulinum A toxin in benign essential blepharospasm: is too high too much? Clin Experiment Ophthalmol 34 441–444 Occurrence Handle16872340 Occurrence Handle10.1111/j.1442-9071.2006.01236.x
YC Park JK Lim DK Lee SD Yi (1993) ArticleTitleBotulinum a toxin treatment of hemifacial spasm and blepharospasm J Korean Med Sci 8 334–340 Occurrence Handle8305141 Occurrence Handle1:STN:280:DyaK2c7jslersg%3D%3D
JH Piatt SuffixJr RH Wilkins (1984) ArticleTitleTreatment of tic douloureux and hemifacial spasm by posterior fossa exploration: therapeutic implications of various neurovascular relationships Neurosurgery 14 462–471 Occurrence Handle6728149 Occurrence Handle10.1097/00006123-198404000-00012
J Reimer K Gilg A Karow J Esser GH Franke (2005) ArticleTitleHealth-related quality of life in blepharospasm or hemifacial spasm Acta Neurol Scand 111 64–70 Occurrence Handle15595940 Occurrence Handle10.1111/j.1600-0404.2004.00357.x Occurrence Handle1:STN:280:DC%2BD2cnitVKktA%3D%3D
CR Rieder P Schestatsky MP Socal TL Monte D Fricke J Costa PD Picon (2007) ArticleTitleA double-blind, randomized, crossover study of prosigne versus botox in patients with blepharospasm and hemifacial spasm Clin Neuropharmacol 30 39–42 Occurrence Handle17272968 Occurrence Handle10.1097/01.WNF.0000236771.77021.3C
P Roggenkamper WH Jost K Bihari G Comes S Grafe (2006) ArticleTitleEfficacy and safety of a new Botulinum Toxin Type A free of complexing proteins in the treatment of blepharospasm J Neural Transm 113 303–312 Occurrence Handle15959841 Occurrence Handle10.1007/s00702-005-0323-3 Occurrence Handle1:CAS:528:DC%2BD28XhtVajt7s%3D
C Sampaio JJ Ferreira F Simoes MJ Rosas M Magalhaes AP Correia A Bastos-Lima R Martins A Castro-Caldas (1997) ArticleTitleDYSBOT: a single-blind, randomized parallel study to determine whether any differences can be detected in the efficacy and tolerability of two formulations of botulinum toxin type A – Dysport and Botox-assuming a ratio of 4:1 Mov Disord 12 1013–1018 Occurrence Handle9399229 Occurrence Handle10.1002/mds.870120627 Occurrence Handle1:STN:280:DyaK1c%2FmtFKhtQ%3D%3D
DI Sandberg MM Souweidane (1999) ArticleTitleHemifacial spasm caused by a pilocytic astrocytoma of the fourth ventricle Pediatr Neurol 21 754–756 Occurrence Handle10580892 Occurrence Handle10.1016/S0887-8994(99)00077-6 Occurrence Handle1:STN:280:DC%2BD3c%2Fks1ymuw%3D%3D
P Schnider P Birner E Moraru E Auff (1999) ArticleTitleLong-term treatment with botulinum toxin: dosage, treatment schedules and costs Wien Klin Wochenschr 111 59–65 Occurrence Handle10081123 Occurrence Handle1:STN:280:DyaK1M7otV2ltg%3D%3D
AB Scott RA Kennedy HA Stubbs (1985) ArticleTitleBotulinum A toxin injection as a treatment for blepharospasm Arch Ophthalmol 103 347–350 Occurrence Handle3977705 Occurrence Handle1:STN:280:DyaL2M7kvVOitg%3D%3D
EK Tan LL Chan SH Lim WE Lim JB Khoo KP Tan (1999) ArticleTitleRole of magnetic resonance imaging and magnetic resonance angiography in patients with hemifacial spasm Ann Acad Med Singapore 28 169–173 Occurrence Handle10497660 Occurrence Handle1:STN:280:DyaK1Mvisleisg%3D%3D
EK Tan S Fook-Chong SY Lum E Lim (2004) ArticleTitleBotulinum toxin improves quality of life in hemifacial spasm: validation of a questionnaire (HFS-30) J Neurol Sci 219 151–155 Occurrence Handle15050451 Occurrence Handle10.1016/j.jns.2004.01.010 Occurrence Handle1:CAS:528:DC%2BD2cXisF2gur0%3D
EK Tan J Jankovic (1999) ArticleTitleBilateral hemifacial spasm: a report of five cases and a literature review Mov Disord 14 345–349 Occurrence Handle10091632 Occurrence Handle10.1002/1531-8257(199903)14:2<345::AID-MDS1023>3.0.CO;2-1 Occurrence Handle1:STN:280:DyaK1M7ptVSmsQ%3D%3D
NC Tan LL Chan EK Tan (2002) ArticleTitleHemifacial spasm and involuntary facial movements QJM 95 493–500 Occurrence Handle12145388 Occurrence Handle10.1093/qjmed/95.8.493
DD Truong WH Jost (2006) ArticleTitleBotulinum toxin: clinical use Parkinsonism Relat Disord 12 331–355 Occurrence Handle16870487 Occurrence Handle10.1016/j.parkreldis.2006.06.002
O Tucha M Naumann D Berg GL Alders KW Lange (2001) ArticleTitleQuality of life in patients with blepharospasm Acta Neurol Scand 103 49–52 Occurrence Handle11153888 Occurrence Handle10.1034/j.1600-0404.2001.00109.x Occurrence Handle1:STN:280:DC%2BD3M7ptFSrtQ%3D%3D
PP Urban (2006) ArticleTitlePregabalin as add-on treatment to botulinum toxin in idiopathic hemifacial spasm Neurology 66 1781 Occurrence Handle16769969 Occurrence Handle10.1212/01.wnl.0000218209.59228.67
A Wang J Jankovic (1998) ArticleTitleHemifacial spasm: clinical findings and treatment Muscle Nerve 21 1740–1747 Occurrence Handle9843077 Occurrence Handle10.1002/(SICI)1097-4598(199812)21:12<1740::AID-MUS17>3.0.CO;2-V Occurrence Handle1:STN:280:DyaK1M%2Flslaisw%3D%3D
DM Yoshimura MJ Aminoff TA Tami AB Scott (1992) ArticleTitleTreatment of hemifacial spasm with botulinum toxin Muscle Nerve 15 1045–1049 Occurrence Handle1518513 Occurrence Handle10.1002/mus.880150909 Occurrence Handle1:STN:280:DyaK38zovF2ksg%3D%3D
Author information
Authors and Affiliations
Corresponding author
Additional information
Correspondence: Christopher Kenney, Parkinson’s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, Texas 77030, USA
Rights and permissions
About this article
Cite this article
Kenney, C., Jankovic, J. Botulinum toxin in the treatment of blepharospasm and hemifacial spasm. J Neural Transm 115, 585–591 (2008). https://doi.org/10.1007/s00702-007-0768-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00702-007-0768-7