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Risk factor of bleeding after endoscopic sphincterotomy in average risk patients

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Abstract

Background

For therapeutic endoscopic retrograde cholangiopancreatography (ERCP), endoscopic sphincterotomy (ES) is necessary but it can lead to complications such as bleeding. Thus, we investigated the risk factors of post-ES bleeding in average risk patients.

Methods

We retrospectively reviewed the medical records of patients who had been treated for ERCP between April 2006 and March 2013. The length of the ES incision was defined as minimal (up to proximal hooding fold), medium (between minimal and full length), and full (up to superior margin of sphincter opening). Exclusion criteria were as follows: if performed precut sphincterotomy or balloon dilatation, patients having altered anatomy or anticoagulant medications.

Results

A total of 3620 patients underwent ERCP and 1121 patients who underwent biliary ES were enrolled. Post-ES bleeding occurred in 108 of 1121 patients (9.6%) and mostly minor bleeding (94 patients, 87%). Length of ES was the only risk factor for post-ES bleeding in multivariate analysis. Complete hemostasis was achieved by endoscopic modalities and no serious complication developed after hemostasis.

Conclusions

In average risk patients, length of ES was independent risk factor for post-ES bleeding and endoscopic hemostasis was safe and effective.

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References

  1. Kaltenthaler EC, Walters SJ, Chilcott J, Blakeborough A, Vergel YB, Thomas S (2006) MRCP compared to diagnostic ERCP for diagnosis when biliary obstruction is suspected: a systematic review. BMC Med Imaging 14:9

    Article  Google Scholar 

  2. Giefer MJ, Kozarek RA (2015) Technical outcomes and complications of pediatric ERCP. Surg Endosc 29(12):3543–3550

    Article  Google Scholar 

  3. Boujaoudé J, Pelletier G, Fritsch J, Choury A, Lefebvre JF, Roche A, Frouge C, Liguory C, Etienne JP (1994) Management of clinically relevant bleeding following endoscopic sphincterotomy. Endoscopy 26(2):217–221

    Article  Google Scholar 

  4. Wilcox CM, Canakis J, Mönkemüller KE, Bondora AW, Geels W (2004) Patterns of bleeding after endoscopic sphincterotomy, the subsequent risk of bleeding, and the role of epinephrine injection. Am J Gastroenterol 99(2):244–248

    Article  Google Scholar 

  5. Nelson D, Freeman ML (1994) Major hemorrhage from endoscopic sphincterotomy: risk factor analysis. J Clin Gastroenterol 19(4):283–287

    Article  CAS  Google Scholar 

  6. Leung JW, Chan FK, Sung JJ, Chung S (1995) Endoscopic sphincterotomy-induced hemorrhage: a study of risk factors and the role of epinephrine injection. Gastrointest Endosc 42(6):550–554

    Article  CAS  Google Scholar 

  7. Hui CK, Lai KC, Yuen MF, Wong WM, Lam SK, Lai CL (2002) Does withholding aspirin for one week reduce the risk of post-sphincterotomy bleeding? Aliment Pharmacol Ther 16(5):929–936

    Article  CAS  Google Scholar 

  8. Rabenstein T, Schneider HT, Hahn EG, Ell C (1998) 25 years of endoscopic sphincterotomy in Erlangen: assessment of the experience in 3498 patients. Endoscopy 30(9):194–201

    Google Scholar 

  9. Christensen M, Matzen P, Schulze S, Rosenberg J (2004) Complications of ERCP: a prospective study. Gastrointest Endosc 60(5):721–731

    Article  Google Scholar 

  10. Freeman ML, Nelson DB, Sherman S, Haber GB, Herman ME, Dorsher PJ, Moore JP, Fennerty MB, Ryan ME, Shaw MJ, Lande JD, Pheley AM (1996) Complications of endoscopic biliary sphincterotomy. N Engl J Med 335(13):909–918

    Article  CAS  Google Scholar 

  11. Loperfido S, Angelini G, Benedetti G, Chilovi F, Costan F, De Berardinis F, De Bernardin M, Ederle A, Fina P, Fratton A (1998) Major early complications from diagnostic and therapeutic ERCP: a prospective multicenter study. Gastrointest Endosc 48(1):1–10

    Article  CAS  Google Scholar 

  12. Tsou YK, Lin CH, Liu NJ, Tang JH, Sung KF, Cheng CL, Lee CS (2009) Treating delayed endoscopic sphincterotomy-induced bleeding: epinephrine injection with or without thermotherapy. World J Gastroenterol 15(38):4823–4828

    Article  CAS  Google Scholar 

  13. Baron TH, Norton ID, Herman L (2000) Endoscopic hemoclip placement for post-sphincterotomy bleeding. Gastrointest Endosc 52(5):662

    Article  CAS  Google Scholar 

  14. Mosca S, Galasso G (1999) Immediate and late bleeding after endoscopic sphincterotomy. Endoscopy 31(3):278–279

    CAS  PubMed  Google Scholar 

  15. Kang MH, Jeong JW, Han JH (2014) Successful hemostasis by using endoscopic band ligation for uncontrolled postendoscopic sphincterotomy bleeding. Gastrointest Endosc 79(2):336–337

    Article  Google Scholar 

  16. Kuran S, Parlak E, Oguz D, Cicek B, Disibeyaz S, Sahin B (2006) Endoscopic sphincterotomy-induced hemorrhage: treatment with heat probe. Gastrointest Endosc 63(3):506–511

    Article  Google Scholar 

  17. Asge Technology Committee, Conway JD, Adler DG, Diehl DL, Farraye FA, Kantsevoy SV, Kaul V, Kethu SR, Kwon RS, Mamula P, Rodriguez SA, Tierney WM (2009) Endoscopic hemostatic devices. Gastrointest Endosc 69(6):987–996

    Article  Google Scholar 

  18. Hori Y, Naitoh I, Nakazawa T, Hayashi K, Miyabe K, Shimizu S, Kondo H, Yoshida M, Yamashita H, Umemura S, Ban T, Okumura F, Sano H, Takada H, Joh T (2014) Feasibility of endoscopic retrograde cholangiopancreatography-related procedures in hemodialysis patients. J Gastroenterol Hepatol 29(3):648–652

    Article  Google Scholar 

  19. Boustière C, Veitch A, Vanbiervliet G, Bulois P, Deprez P, Laquiere A, Laugier R, Lesur G, Mosler P, Nalet B, Napoleon B, Rembacken B, Ajzenberg N, Collet JP, Baron T, Dumonceau JM, European Society of Gastrointestinal Endoscopy (2011) Endoscopy and antiplatelet agents. European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy 43(5):445–461

    Article  Google Scholar 

  20. ASGE Standards of Practice Committee, Anderson MA, Ben-Menachem T, Gan SI, Appalaneni V, Banerjee S, Cash BD, Fisher L, Harrison ME, Fanelli RD, Fukami N, Ikenberry SO, Jain R, Khan K, Krinsky ML, Lichtenstein DR, Maple JT, Shen B, Strohmeyer L, Baron T, Dominitz JA (2009) Management of antithrombotic agents for endoscopic procedures. Gastrointest Endosc 70(6):1060–1070

    Article  Google Scholar 

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Correspondence to Dong Wook Lee.

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Disclosures

Sang Soo Bae, Dong Wook Lee, Jimin Han, and Ho Gak Kim have no conflicts of interest or financial ties to disclosure.

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Bae, S.S., Lee, D.W., Han, J. et al. Risk factor of bleeding after endoscopic sphincterotomy in average risk patients. Surg Endosc 33, 3334–3340 (2019). https://doi.org/10.1007/s00464-018-06623-8

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  • DOI: https://doi.org/10.1007/s00464-018-06623-8

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