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Efficacy and Safety of Emodepside 2.1 %/Praziquantel 8.6% Spot-on Formulation in the Treatment of Feline Aelurostrongylosis

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Abstract

The objective of the present study was to evaluate the efficacy and safety of the antiparasitic spot-on formulation containing emodepside 2.1 %/praziquantel 8.6% (Profender®, Bayer) in the treatment of natural feline infection with the lungworm Aelurostrongylus abstrusus (Nematoda, Strongylida). Efficacy of Profender® given once at the licensed dose was tested in comparison to a control oral formulation containing fenbendazole 18.75 % (Panacur®, Intervet) given over three consecutive days at the licensed dose. Efficacy assessment was based on larvae per gramme of faeces (LPG) counts, measured on days 28 ± 2 following treatment and compared to counts on days –6 to –2. In total 24 cats treated either with Profender® (n = 12) or with Panacur (n = 12) were included in the assessment of efficacy and safety. Mean LPG post-baseline counts (days 28 ± 2) were 1.3 LPG for both Profender® and Panacur®, demonstrating similar efficacy of 99.38 % for Profender® and 99.29 % for the control product. No treated animals showed adverse events. This trial demonstrated that both Profender® spot-on formulation and oral paste Panacur® are safe and effective in the treatment of aelurotrongylosis in cats. Future practical perspectives in feline medicine and the major advantages of the spot-on product compared to the oral paste are discussed.

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Authors and Affiliations

  1. Department of Comparative Biomedical Sciences, Faculty of Veterinary Medicine, Teramo, Italy

    Donato Traversa, Piermarino Milillo, Angela Di Cesare, Raffaella Iorio & Roberto Bartolini

  2. Klifovet, Munich, Germany

    Beate Lohr

  3. Bayer Animal Health, Milano, Italy

    Fabrizio Pampurini

  4. Bayer Animal Health GmbH, Leverkusen, Germany

    Roland Schaper & Josef Heine

Authors
  1. Donato Traversa
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  2. Piermarino Milillo
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  3. Angela Di Cesare
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  4. Beate Lohr
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  5. Raffaella Iorio
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  6. Fabrizio Pampurini
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  7. Roland Schaper
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  8. Roberto Bartolini
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  9. Josef Heine
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Correspondence to Donato Traversa.

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Traversa, D., Milillo, P., Di Cesare, A. et al. Efficacy and Safety of Emodepside 2.1 %/Praziquantel 8.6% Spot-on Formulation in the Treatment of Feline Aelurostrongylosis. Parasitol Res 105 (Suppl 1), 83–90 (2009). https://doi.org/10.1007/s00436-009-1499-5

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  • DOI: https://doi.org/10.1007/s00436-009-1499-5

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