Skip to main content

Advertisement

Log in

Duodenal histological features in suspected non-celiac gluten sensitivity: new insights into a still undefined condition

  • Brief Report
  • Published:
Virchows Archiv Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

References

  1. Molina-Infante J, Carroccio A (2017) Suspected nonceliac gluten sensitivity confirmed in few patients after gluten challenge in double-blind, placebo-controlled trials. Clin Gastroenterol Hepatol 15:339–348

    Article  PubMed  Google Scholar 

  2. Catassi C, Elli L, Bonaz B, Bouma C, Carroccio A, Castilllejo G et al (2015) Diagnosis of non-celiac gluten sensitivity (NCGS): the Salerno Experts’ criteria. Nutrients 7:4966–4977

    Article  PubMed  PubMed Central  Google Scholar 

  3. Gibson P, Skodje GI, Lundin KEA (2017) Non-coeliac gluten sensitivity. J Gastroenterol Hepatol 32(Suppl 1):86–89

    Article  PubMed  CAS  Google Scholar 

  4. Uhde M, Ajamian M, Caio G, De Giorgio R, Indart A, Green PH et al (2016) Markers of intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of celiac disease. Gut 63(11):1930–1937

    Article  CAS  Google Scholar 

  5. Talley NJ, Walker MM (2017) Celiac disease and nonceliac gluten or wheat sensitivity. The Risks and Benefits of Diagnosis JAMA 177(5):615–616

    Google Scholar 

  6. Lanzini A, Lanzarotto F, Villanacci V, Mora A, Bertolazzi S, Turini D et al (2009) Complete recovery of intestinal mucosa occurs very rarely in adult celiac patients despite adherence to gluten free diet. Aliment Pharmacol Ther 29(12):1299–1308

    Article  PubMed  CAS  Google Scholar 

  7. Zanini B, Baschè R, Ferraresi A, Ricci C, Lanzarotto F, Marullo M, Villanacci V, Hidalgo A, Lanzini A (2015) A randomised clinical study: gluten challenge induces symptom recurrence in only a minority of patients who meet clinical criteria for non-coeliac gluten sensitivity. Aliment Pharmacol Ther 42:968–976

    Article  PubMed  CAS  Google Scholar 

  8. Ravelli A, Villanacci V (2012) Tricks of the trade: how to avoid histological pitfalls in celiac disease. Pathol Res Pract 208(4):197–202

    Article  PubMed  Google Scholar 

  9. Villanacci V, Ceppa P, Tavani E, Vindigni C, Volta U (2011) Coeliac disease: the histology report. Dig Liver Dis 43(Suppl 4):S385–S395

    Article  PubMed  Google Scholar 

  10. Walker MM, Murray JA, Ronkainen J, Aro P, Storskrubb T, D’Amato M et al (2010) Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study. Gastroenterology 139(1):112–119

    Article  PubMed  PubMed Central  Google Scholar 

  11. Hayat M, Cairns A, Dixon MF, O’Mahony S (2002) Quantitation of intraepithelial lymphocytes in human duodenum: what is normal? J Clin Pathol 55(5):393–394

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. Hurrell JM, Genta RM, Meltin SD (2011) Histopathologic diagnosis of eosinophilic conditions in the gastrointestinal tract. Adv Anat Pathol 18(5):335–348

    Article  PubMed  CAS  Google Scholar 

  13. Corazza GR, Villanacci V, Zambelli C, Milione M, Luinetti O, Vindigni C, Chioda C, Albarello L, Bartolini D, Donato F (2007) Comparison of the interobserver reproducibility with different histologic criteria used in celiac disease. Clin Gastroenterol Hepatol 5:838–843

    Article  PubMed  Google Scholar 

  14. Oberhuber G, Granditsch G, Vogelsang H (1999) The histopathology of coeliac disease: time for a standardized report scheme of pathologists. Eur J Gastro Hepatol 11:1185–1194

    Article  CAS  Google Scholar 

  15. Bardella MT, Elli L, Ferretti F (2016) Non celiac gluten sensitivity. Curr Gastroenterol Rep 18(12):63

    Article  PubMed  Google Scholar 

  16. Molina-Infante J, Santolaria S, Sanders DS, Fernández-Bañares F (2015) Systematic review: nonceliac gluten sensitivity. Aliment Pharmacol Ther 41:807–820

    Article  PubMed  CAS  Google Scholar 

  17. Watkins RD, Zawahir S (2017) Celiac disease and nonceliac gluten sensitivity. Pediatr Clin N Am 64:563–576

    Article  Google Scholar 

  18. Rothenberg ME, Hogan SP (2006) The eosinophil. Annu Rev Immunol 24:147–174

    Article  PubMed  CAS  Google Scholar 

  19. Villanacci V, Lanzini A, Lanzarotto F, Ricci C (2013) Observations on the paper of Carroccio et al. “non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity”. Am J Gastroenterol 108:619–620

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Barbara Zanini.

Ethics declarations

The authors declare that the study has been done according to ethical standards.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical responsibilities of authors section

All the authors are qualified for the following criteria:

• Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work;

• Drafting the work or revising it critically for important intellectual content;

• Final approval of the version to be published; and

• Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zanini, B., Villanacci, V., Marullo, M. et al. Duodenal histological features in suspected non-celiac gluten sensitivity: new insights into a still undefined condition. Virchows Arch 473, 229–234 (2018). https://doi.org/10.1007/s00428-018-2346-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-018-2346-9

Navigation