Abstract
Evidence for the role of sleep on metabolic and endocrine function has been reported more than four decades ago. In the past 30 years, the prevalence of obesity and diabetes has greatly increased in industrialized countries, and self-imposed sleep curtailment, now very common, is starting to be recognized as a contributing factor, alongside with increased caloric intake and decreased physical activity. Furthermore, obstructive sleep apnea, a chronic condition characterized by recurrent upper airway obstruction leading to intermittent hypoxemia and sleep fragmentation, has also become highly prevalent as a consequence of the epidemic of obesity and has been shown to contribute, in a vicious circle, to the metabolic disturbances observed in obese patients. In this article, we summarize the current data supporting the role of sleep in the regulation of glucose homeostasis and the hormones involved in the regulation of appetite. We also review the results of the epidemiologic and laboratory studies that investigated the impact of sleep duration and quality on the risk of developing diabetes and obesity, as well as the mechanisms underlying this increased risk. Finally, we discuss how obstructive sleep apnea affects glucose metabolism and the beneficial impact of its treatment, the continuous positive airway pressure. In conclusion, the data available in the literature highlight the importance of getting enough good sleep for metabolic health.
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References
Ahima RS, Saper CB, Flier JS, Elmquist JK (2000) Leptin regulation of neuroendocrine systems. Front Neuroendocrinol 21:263–307
Aronsohn RS, Whitmore H, Van Cauter E, Tasali E (2010) Impact of untreated obstructive sleep apnea on glucose control in type 2 diabetes. Am J Respir Crit Care Med 181:507–513
Avram AM, Jaffe CA, Symons KV, Barkan AL (2005) Endogenous circulating ghrelin does not mediate growth hormone rhythmicity or response to fasting. J Clin Endocrinol Metabol 90:2982–2987
Babu AR, Herdegen J, Fogelfeld L, Shott S, Mazzone T (2005) Type 2 diabetes, glycemic control, and continuous positive airway pressure in obstructive sleep apnea. Arch Intern Med 165:447–452
Benedict C et al (2011) Acute sleep deprivation reduces energy expenditure in healthy men. Am J Clin Nutr 93:1229–1236
Bergman RN (1989) Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach. Diabetes 38:1512–1527
Bergman RN (2005) Minimal model: perspective from 2005. Horm Res 64(Suppl 3):8–15
Bo S et al (2011) Contributors to the obesity and hyperglycemia epidemics. A prospective study in a population-based cohort. Int J Obes. doi:10.1038/ijo.2011.5
Bodosi B et al (2004) Rhythms of ghrelin, leptin, and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation. Am J Physiol 287:R1071–R1079
Bonnet MH, Berry RB, Arand DL (1991) Metabolism during normal, fragmented, and recovery sleep. J Appl Physiol 71:1112–1118
Bosy-Westphal A et al (2008) Influence of partial sleep deprivation on energy balance and insulin sensitivity in healthy women. Obes Facts 1:266–273
Boyle PJ et al (1994) Diminished brain glucose metabolism is a significant determinant for falling rates of systemic glucose utilization during sleep in normal humans. J Clin Invest 93:529–535
Briones B et al (1996) Relationship between sleepiness and general health status. Sleep 19:583–588
Brondel L, Romer MA, Nougues PM, Touyarou P, Davenne D (2010) Acute partial sleep deprivation increases food intake in healthy men. Am J Clin Nutr 91:1550–1559
Brooks B et al (1994) Obstructive sleep apnea in obese noninsulin-dependent diabetic patients: effects of continuous positive airway pressure treatment on insulin responsiveness. J Clin Endocrinol Metabol 79:1681–1685
Buxton OM et al (2010) Sleep restriction for 1 week reduces insulin sensitivity in healthy men. Diabetes 59:2126–2133
Callahan HS et al (2004) Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humans. J Clin Endocrinol Metabol 89:1319–1324
Cappuccio FP et al (2008) Meta-analysis of short sleep duration and obesity in children and adults. Sleep 31:619–626
Cappuccio FP, D’Elia L, Strazzullo P, Miller MA (2010) Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care 33:414–420
Carneiro G et al (2009) Continuous positive airway pressure therapy improves hypoadiponectinemia in severe obese men with obstructive sleep apnea without changes in insulin resistance. Metab Syndr Relat Disord 7:537–542
Carter PJ, Taylor BJ, Williams SM, Taylor RW (2011) Longitudinal analysis of sleep in relation to BMI and body fat in children: the FLAME study. BMJ 342:d2712
Chaput JP, Despres JP, Bouchard C, Tremblay A (2007) Short sleep duration is associated with reduced leptin levels and increased adiposity: results from the Quebec family study. Obesity (Silver Spring, Md) 15:253–261
Chen X, Beydoun MA, Wang Y (2008) Is sleep duration associated with childhood obesity? A systematic review and meta-analysis. Obesity (Silver Spring, Md) 16:265–274
Chin K et al (1999) Changes in intra-abdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy. Circulation 100:706–712
Chin-Chance C, Polonsky KS, Schoeller DA (2000) Twenty-four-hour leptin levels respond to cumulative short-term energy imbalance and predict subsequent intake. J Clin Endocrinol Metabol 85:2685–2691
Chung S, Yoon IY, Lee CH, Kim JW (2011) The effects of nasal continuous positive airway pressure on vascular functions and serum cardiovascular risk factors in obstructive sleep apnea syndrome. Sleep Breath 15:71–76
Cizza G et al (2010) Treatment of obesity with extension of sleep duration: a randomized, prospective, controlled trial. Clin Trials 7:274–285
Colditz GA, Willett WC, Rotnitzky A, Manson JE (1995) Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med 122:481–486
Comondore VR et al (2009) The impact of CPAP on cardiovascular biomarkers in minimally symptomatic patients with obstructive sleep apnea: a pilot feasibility randomized crossover trial. Lung 187:17–22
Coughlin SR, Mawdsley L, Mugarza JA, Wilding JP, Calverley PM (2007) Cardiovascular and metabolic effects of CPAP in obese males with OSA. Eur Respir J 29:720–727
Cuhadaroglu C, Utkusavas A, Ozturk L, Salman S, Ece T (2009) Effects of nasal CPAP treatment on insulin resistance, lipid profile, and plasma leptin in sleep apnea. Lung 187:75–81
Cummings DE et al (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50:1714–1719
Cummings DE, Frayo RS, Marmonier C, Aubert R, Chapelot D (2004) Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues. Am J Physiol Endocrinol Metab 287:E297–E304
Danaei G et al (2011) National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet 378:31–40
Danguir J, Nicolaidis S (1979) Dependence of sleep on nutrients’ availability. Physiol Behav 22:735–740
de Lima AMJ et al (2010) Effects of nasal continuous positive airway pressure treatment on oxidative stress and adiponectin levels in obese patients with obstructive sleep apnea. Respiration 79:370–376
DeFronzo RA (2004) Pathogenesis of type 2 diabetes mellitus. Med Clin North Am 88:787–835, ix
Diethelm K, Bolzenius K, Cheng G, Remer T, Buyken AE (2011) Longitudinal associations between reported sleep duration in early childhood and the development of body mass index, fat mass index and fat free mass index until age 7. Int J Pediatr Obes 6:e114–e123
Dimaraki EV, Jaffe CA (2006) Role of endogenous ghrelin in growth hormone secretion, appetite regulation and metabolism. Rev Endocr Metab Disord 7:237–249
Dinges DF, Chugh DK (1997) Physiological correlates of sleep deprivation. In: Kinney JM, Tucker HN (eds) Physiology, stress, and malnutrition: functional correlates, nutritional intervention. Lippincott-Raven, Philadelphia
Donga E et al (2010) A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects. J Clin Endocrinol Metabol 95:2963–2968
Dorkova Z, Petrasova D, Molcanyiova A, Popovnakova M, Tkacova R (2008) Effects of continuous positive airway pressure on cardiovascular risk profile in patients with severe obstructive sleep apnea and metabolic syndrome. Chest 134:686
Dworak M, McCarley RW, Kim T, Kalinchuk AV, Basheer R (2010) Sleep and brain energy levels: ATP changes during sleep. J Neurosci 30:9007–9016
Dzaja A et al (2004) Sleep enhances nocturnal plasma ghrelin levels in healthy subjects. Am J Physiol Endocrinol Metab 286:E963–E967
Einhorn D et al (2007) Prevalence of sleep apnea in a population of adults with type 2 diabetes mellitus. Endocr Pract 13:355–362
Eliassen AH, Colditz GA, Rosner B, Willett WC, Hankinson SE (2006) Adult weight change and risk of postmenopausal breast cancer. JAMA 296:193–201
Eskelinen V, Uibu T, Himanen SL (2007) nCPAP treatment of obstructive sleep apnea increases slow wave sleep in prefrontal EEG. Clin EEG Neurosci 38:148
Espelund U et al (2005) Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects. J Clin Endocrinol Metabol 90:741–746
Estabrooke IV et al (2001) Fos expression in orexin neurons varies with behavioral state. J Neurosci 21:1656–1662
Feng DD et al (2011) Ghrelin and obestatin modulate growth hormone-releasing hormone release and synaptic inputs onto growth hormone-releasing hormone neurons. Eur J Neurosci 34:732–744
Fietze I, Quispe Bravo S, Hänsch T, Röttig J, Baumann C (1997) Arousals and sleep stages in patients with obstructive sleep apnoea syndrome: changes under nCPAP treatment. J Sleep Res 6:128–133
Foster GD et al (2009) Obstructive sleep apnea among obese patients with type 2 diabetes. Diabetes Care 32:1017–1019
Fraser G, Trinder J, Colrain IM, Montgomery I (1989) Effect of sleep and circadian cycle on sleep period energy expenditure. J Appl Physiol 66:830–836
Garcia G et al (1997) Glucose metabolism in older adults: a study including subjects more than 80 years of age. J Am Geriatr Soc 45:813–817
Garcia JM, Sharafkaneh H, Hirshkowitz M, Elkhatib R, Sharafkhaneh H (2011) Weight and metabolic effects of CPAP in obstructive sleep apnea patients with obesity. Respir Res 12:80–88
Gasco V et al (2010) Endocrine and metabolic actions of ghrelin. Endocr Dev 17:86–95
Gonzalez-Ortiz M, Martinez-Abundis E, Balcazar-Munoz BR, Pascoe-Gonzalez S (2000) Effect of sleep deprivation on insulin sensitivity and cortisol concentration in healthy subjects. Diabetes Nutr Metab 13:80–83
Granata R, Baragli A, Settanni F, Scarlatti F, Ghigo E (2010) Unraveling the role of the ghrelin gene peptides in the endocrine pancreas. J Mol Endocrinol 45:107–118
Gronfier C, Brandenberger G (1998) Ultradian rhythms in pituitary and adrenal hormones: their relations to sleep. Sleep Med Rev 2:17–29
Gross TM, Mastrototaro JJ (2000) Efficacy and reliability of the continuous glucose monitoring system. Diabetes Technol Ther 2:19–26
Guilleminault C et al (2001) Sleep and daytime sleepiness in upper airway resistance syndrome compared to obstructive sleep apnoea syndrome. Eur Respir J 17:838
Guilleminault C et al (2003) Preliminary observations on the effects of sleep time in a sleep restriction paradigm. Sleep Med 4:177–184
Gupta NK, Mueller WH, Chan W, Meininger JC (2002) Is obesity associated with poor sleep quality in adolescents? Am J Hum Biol 14:762–768
Haddad GG (2011) Does the brain gain back energy during sleep? But what does it mean? Sleep 34:835–836, author reply 841–833
Harsch IA et al (2004) Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome. Am J Respir Crit Care Med 169:156–162
Harsch IA et al (2004) The effect of continuous positive airway pressure treatment on insulin sensitivity in patients with obstructive sleep apnoea syndrome and type 2 diabetes. Respiration 71:252–259
Hasler G et al (2004) The association between short sleep duration and obesity in young adults: a 13-year prospective study. Sleep 27:661–666
Hassaballa HA, Tulaimat A, Herdegen JJ, Mokhlesi B (2005) The effect of continuous positive airway pressure on glucose control in diabetic patients with severe obstructive sleep apnea. Sleep & breathing = Schlaf & Atmung 9:176–180
Heinzer R et al (2001) Slow-wave activity in sleep apnea patients before and after continuous positive airway pressure treatment*. Chest 119:1807
Heller HC (2011) Repeatability is not the same as accuracy. Sleep 34:839, author reply 841–833
Henley DE et al (2009) Plasma apelin levels in obstructive sleep apnea and the effect of continuous positive airway pressure therapy. J Endocrinol 203:181–188
Henley DE et al (2009) Hypothalamic–pituitary–adrenal axis activation in obstructive sleep apnea: the effect of continuous positive airway pressure therapy. J Clin Endocrinol Metabol 94:4234
Hill JO, Wyatt HR, Reed GW, Peters JC (2003) Obesity and the environment: where do we go from here? Science (New York, NY) 299:853–855
Horne J (2011) Obesity and short sleep: unlikely bedfellows? Obes Rev 12:e84–e94
Institut National de Prévention et d’Education pour la Santé. Les français et leur sommeil. http://www.inpes.sante.fr/70000/dp/08/dp080310.pdf. 1–45.
Ip MS, Lam KS, Ho C, Tsang KW, Lam W (2000) Serum leptin and vascular risk factors in obstructive sleep apnea. Chest 118:580–586
Ip MSM et al (2002) Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med 165:670
Jung CM et al (2011) Energy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in adult humans. J Physiol 589:235–244
Kahn SE (2003) The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46:3–19
Knutson KL (2010) Sleep duration and cardiometabolic risk: a review of the epidemiologic evidence. Best Pract Res Clin Endocrinol Metab 24:731–743
Knutson KL, Leproult R (2010) Apples to oranges: comparing long sleep to short sleep. J Sleep Res 19:118
Knutson KL, Van Cauter E (2008) Associations between sleep loss and increased risk of obesity and diabetes. Ann N Y Acad Sci 1129:287–304
Knutson KL, Galli G, Zhao X, Mattingly M, Cizza G (2011) No association between leptin levels and sleep duration or quality in obese adults. Obesity (Silver Spring). doi:10.1038/oby.2011.248
Kolaczynski JW et al (1996) Responses of leptin to short-term fasting and refeeding in humans: a link with ketogenesis but not ketones themselves. Diabetes 45:1511–1515
Koutkia P, Canavan B, Breu J, Johnson ML, Grinspoon SK (2004) Nocturnal ghrelin pulsatility and response to growth hormone secretagogues in healthy men. Am J Physiol Endocrinol Metab 287:E506–E512
Kuhn E, Brodan V, Brodanova M, Rysanek K (1969) Metabolic reflection of sleep deprivation. Act Nerv Super (Praha) 11:165–174
Kumor M, Bielicki P, Pzybylowski T, Rubinsztajn R, Zielinski J (2011) Three-month continuous positive airway pressure (CPAP) treatmetn decreases total LDL-cholesterol levels but does not affect serum homocysteine and leptin levels in patients with obstructive sleep apnea syndrome (OSAS) without co-existent ischaemic heart disease (IHD). Pol Pneumonol Allergol 79:173–183
Lam JC et al (2010) A randomised controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnoea. Eur Respir J 35:138–145
Landhuis CE, Poulton R, Welch D, Hancox RJ (2008) Childhood sleep time and long-term risk for obesity: a 32-year prospective birth cohort study. Pediatrics 122:955–960
Laposky AD et al (2006) Altered sleep regulation in leptin-deficient mice. Am J Physiol 290:R894–R903
Leproult R, Van Cauter E (2006) Marked decreased insulin sensitivity and increased evening cortisol levels following one week of partial sleep deprivation. In 12th meeting of the European NeuroEndocrine Association (ENEA), Athens, Greece
Lim CT, Kola B, Korbonits M, Grossman AB (2010) Ghrelin’s role as a major regulator of appetite and its other functions in neuroendocrinology. Prog Brain Res 182:189–205
Lindberg E, Berne C, Elmasry A, Hedner J, Janson C (2006) CPAP treatment of a population-based sample—what are the benefits and the treatment compliance? Sleep Med 7:553–560
Littman AJ et al (2007) Sleep, ghrelin, leptin and changes in body weight during a 1-year moderate-intensity physical activity intervention. Int J Obes 31:466–475
Liu J et al (2008) Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men. J Clin Endocrinol Metabol 93:1980–1987
Lyssenko V et al (2005) Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes. Diabetes 54:166–174
Lyytikainen P, Rahkonen O, Lahelma E, Lallukka T (2011) Association of sleep duration with weight and weight gain: a prospective follow-up study. J Sleep Res 20:298–302
Magee L, Hale L (2011) Longitudinal associations between sleep duration and subsequent weight gain: a systematic review. Sleep Med Rev. doi:10.1016/j.smrv.2011.05.005
Magee CA, Huang X-F, Iverson DC, Caputi P (2009) Acute sleep restriction alters neuroendocrine hormones and appetite in healthy male adults. Sleep Biol Rhythms 7:125–127
Marshall NS, Glozier N, Grunstein RR (2008) Is sleep duration related to obesity? A critical review of the epidemiological evidence. Sleep Med Rev 12:289–298
Marshall NS et al (2010) Changes in sleep duration and changes in weight in obese patients: the Swedish obese subjects study. Sleep Biol Rhythms 8:63–71
McAllister EJ et al (2009) Ten putative contributors to the obesity epidemic. Crit Rev Food Sci Nutr 49:868–913
Møller N et al (1990) Effects of a growth hormone pulse on total and forearm substrate fluxes in humans. Am J Physiol 258:E86–E91
Morselli L, Balbo M, Van Cauter E, Guyon A, Spiegel K (2011) Impact of sleep restriction on the regulation of appetite in middle-aged obese subjects. In 4th International World Sleep Congress, Quebec City, Québec
Mozaffarian D, Hao T, Rimm EB, Willett WC, Hu FB (2011) Changes in diet and lifestyle and long-term weight gain in women and men. N Engl J Med 364:2392–2404
Muller AF et al (2002) Ghrelin drives GH secretion during fasting in man. Eur J Endocrinol 146:203–207
Mullington JM et al (2003) Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men. J Neuroendocrinol 15:851–854
Muniyappa R, Lee S, Chen H, Quon MJ (2008) Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab 294:E15
Murri M et al (2009) Oxidative stress and metabolic changes after continuous positive airway pressure treatment according to previous metabolic disorders in sleep apnea–hypopnea syndrome patients. Transl Res 154:111–121
Nakra N, Bhargava S, Dzuira J, Caprio S, Bazzy-Asaad A (2008) Sleep-disordered breathing in children with metabolic syndrome: the role of leptin and sympathetic nervous system activity and the effect of continuous positive airway pressure. Pediatrics 122:e634–e642
Narkiewicz K, Somers V (2003) Sympathetic nerve activity in obstructive sleep apnoea. Acta Physiol Scand 177:385–390
Nass R et al (2008) Evidence for acyl-ghrelin modulation of growth hormone release in the fed state. J Clin Endocrinol Metabol 93:1988–1994
Natalucci G, Riedl S, Gleiss A, Zidek T, Frisch H (2005) Spontaneous 24-h ghrelin secretion pattern in fasting subjects: maintenance of a meal-related pattern. Eur J Endocrinol 152:845–850
National Sleep Foundation (2008) “Sleep in America” Poll. http://www.sleepfoundation.org./sites/default/files/2008%20POLL%20SOF.PDF. 1–45
Nedeltcheva AV, Kessler L, Imperial J, Penev PD (2009) Exposure to recurrent sleep restriction in the setting of high caloric intake and physical inactivity results in increased insulin resistance and reduced glucose tolerance. J Clin Endocrinol Metabol 94:3242–3250
Nedeltcheva AV et al (2009) Sleep curtailment is accompanied by increased intake of calories from snacks. Am J Clin Nutr 89:126–133
Nedeltcheva AV, Kilkus JM, Imperial J, Schoeller DA, Penev PD (2010) Insufficient sleep undermines dietary efforts to reduce adiposity. Ann Intern Med 153:435–441
Nena E et al (2010) Reduction of serum retinol-binding protein-4 levels in nondiabetic obstructive sleep apnea patients under continuous positive airway pressure treatment. Respiration 80:517–523
Nielsen LS, Danielsen KV, Sorensen TI (2011) Short sleep duration as a possible cause of obesity: critical analysis of the epidemiological evidence. Obes Rev 12:78–92
Nishiura C, Hashimoto H (2010) A 4-year study of the association between short sleep duration and change in body mass index in Japanese male workers. J Epidemiol 20:385–390
Oktay B, Akbal E, Firat H, Ardiç S, Kizilgun M (2009) CPAP treatment in the coexistence of obstructive sleep apnea syndrome and metabolic syndrome, results of one year follow up. Acta Clin Belg 64:329–334
Omisade A, Buxton OM, Rusak B (2010) Impact of acute sleep restriction on cortisol and leptin levels in young women. Physiol Behav 99:651–656
Palmer ND et al (2006) Genetic mapping of disposition index and acute insulin response loci on chromosome 11q. The Insulin Resistance Atherosclerosis Study (IRAS) Family Study. Diabetes 55:911–918
Patel SR, Hu FB (2008) Short sleep duration and weight gain: a systematic review. Obesity (Silver Spring, Md) 16:643–653
Patel SR et al (2008) The association between sleep duration and obesity in older adults. Int J Obes 32:1825–1834
Pejovic S et al (2010) Leptin and hunger levels in young healthy adults after one night of sleep loss. J Sleep Res 19:552–558
Peters A (2011) The selfish brain: competition for energy resources. Am J Hum Biol 23:29–34
Petrie JR, Pearson ER, Sutherland C (2011) Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology. Biochem Pharmacol 81:471–477
Plat L et al (1996) Effects of morning cortisol elevation on insulin secretion and glucose regulation in humans. Am J Physiol 270:E36–E42
Plat L et al (1999) Metabolic effects of short-term elevations of plasma cortisol are more pronounced in the evening than in the morning. J Clin Endocrinol Metabol 84:3082–3092
Punjabi NM et al (2004) Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. Am J Epidemiol 160:521–530
Raynor HA, Wing RR (2007) Package unit size and amount of food: do both influence intake? Obesity (Silver Spring Md) 15:2311–2319
Rechtschaffen A, Bergmann BM (1995) Sleep deprivation in the rat by the disk-over-water method. Behav Brain Res 69:55–63
Resnick HE et al (2003) Diabetes and sleep disturbances: findings from the Sleep Heart Health Study. Diabetes Care 26:702–709
Rexrode KM et al (1997) A prospective study of body mass index, weight change, and risk of stroke in women. JAMA 277:1539–1545
Rolls A, Schaich Borg J, De Lecea L (2010) Sleep and metabolism: role of hypothalamic neuronal circuitry. Best Pract Res Clin Endocrinol Metab 24:817–828
Ryden L et al (2007) Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur Heart J 28:88–136
Saarelainen S, Lahtela J, Kallonen E (1997) Effect of nasal CPAP treatment on insulin sensitivity and plasma leptin. J Sleep Res 6:146–147
Sakurai T (2007) The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nat Rev Neurosci 8:171–181
Samuel VT, Petersen KF, Shulman GI (2010) Lipid-induced insulin resistance: unravelling the mechanism. Lancet 375:2267–2277
Sanders M (2005) Sleep breathing disorders. In: Kryger M, Roth T, Dement WC (eds) Principles and practice of sleep medicine. Saunders, Philadelphia, pp 969–1157
Schahin SP et al (2008) Long-term improvement of insulin sensitivity during CPAP therapy in the obstructive sleep apnoea syndrome. Med Sci Mon 14:CR117–CR121
Schmid SM et al (2007) Sleep loss alters basal metabolic hormone secretion and modulates the dynamic counterregulatory response to hypoglycemia. J Clin Endocrinol Metabol 92:3044–3051
Schmid SM, Hallschmid M, Jauch-Chara K, Born J, Schultes B (2008) A single night of sleep deprivation increases ghrelin levels and feelings of hunger in normal-weight healthy men. J Sleep Res 17:331–334
Schmid SM, Jauch-Chara K, Hallschmid M, Schultes B (2009) Mild sleep restriction acutely reduces plasma glucagon levels in healthy men. J Clin Endocrinol Metabol 94:5169–5173
Schmid SM et al (2009) Short-term sleep loss decreases physical activity under free-living conditions but does not increase food intake under time-deprived laboratory conditions in healthy men. Am J Clin Nutr 90:1476–1482
Schmid SM et al (2011) Disturbed glucoregulatory response to food intake after moderate sleep restriction. Sleep 34:371–377
Schoeller DA, Cella LK, Sinha MK, Caro JF (1997) Entrainment of the diurnal rhythm of plasma leptin to meal timing. J Clin Invest 100:1882–1887
Schuessler P et al (2005) Nocturnal ghrelin levels—relationship to sleep EEG, the levels of growth hormone, ACTH and cortisol—and gender differences. J Sleep Res 14:329–336
Seegers V et al (2011) Short sleep duration and body mass index: a prospective longitudinal study in preadolescence. Am J Epidemiol 173:621–629
Simon C, Brandenberger G, Follenius M (1987) Ultradian oscillations of plasma glucose, insulin, and C-peptide in man during continuous enteral nutrition. J Clin Endocrinol Metabol 64:669–674
Simon C, Brandenberger G, Saini J, Ehrhart J, Follenius M (1994) Slow oscillations of plasma glucose and insulin secretion rate are amplified during sleep in humans under continuous enteral nutrition. Sleep 17:333–338
Simon C, Gronfier C, Schlienger JL, Brandenberger G (1998) Circadian and ultradian variations of leptin in normal man under continuous enteral nutrition: relationship to sleep and body temperature. J Clin Endocrinol Metabol 83:1893–1899
Simpson NS, Banks S, Dinges DF (2010) Sleep restriction is associated with increased morning plasma leptin concentrations, especially in women. Biol Res Nurs 12:47–53
Sinton CM, Fitch TE, Gershenfeld HK (1999) The effects of leptin on REM sleep and slow wave delta in rats are reversed by food deprivation. J Sleep Res 8:197–203
Smurra M et al (2001) CPAP treatment does not affect glucose-insulin metabolism in sleep apneic patients. Sleep Med 2:207–213
Somers VK, Dyken ME, Clary MP, Abboud FM (1995) Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 96:1897
Sorensen TI (2009) Conference on “Multidisciplinary approaches to nutritional problems”. Symposium on “Diabetes and health”. Challenges in the study of causation of obesity. Proc Nutr Soc 68:43–54
Spiegel K, Leproult R, Van Cauter E (1999) Impact of sleep debt on metabolic and endocrine function. Lancet 354:1435–1439
Spiegel K et al (2000) Adaptation of the 24-h growth hormone profile to a state of sleep debt. Am J Physiol 279:R874–R883
Spiegel K et al (2004) Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J Clin Endocrinol Metabol 89:5762–5771
Spiegel K, Tasali E, Penev P, Van Cauter E (2004) Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med 141:846–850
Spiegel K et al (2005) The 24-hour profile of plasma PYY levels in normal adults: relationships with sleep, meal intake and ghrelin levels. In: The Endocrine Society’s 87th Annual Meeting Abstract number OR8-3, San Diego, CA, USA, June 2005, pp. 82–83
Spiegel K, Knutson K, Leproult R, Tasali E, Van Cauter E (2005) Sleep loss: a novel risk factor for insulin resistance and type 2 diabetes. J Appl Physiol 99:2008–2019
Spiegel K, Tasali E, Leproult R, Van Cauter E (2009) Effects of poor and short sleep on glucose metabolism and obesity risk. Nat Rev 5:253–261
Spiegel K, Tasali E, Leproult R, Scherberg N, Van Cauter E (2011) Twenty-four-hour profiles of acylated and total ghrelin: relationship with glucose levels and impact of time of day and sleep. J Clin Endocrinol Metabol 96:486–493
Stamatakis KA, Punjabi NM (2010) Effects of sleep fragmentation on glucose metabolism in normal subjects. Chest 137:95–101
Steiger A (2003) Sleep and endocrinology. J Intern Med 254:13–22
Steiropoulos P et al (2009) Markers of glycemic control and insulin resistance in non-diabetic patients with obstructive sleep apnea hypopnea syndrome: does adherence to CPAP treatment improve glycemic control? Sleep Med 10:887–891
St-Onge MP et al (2011) Short sleep duration increases energy intakes but does not change energy expenditure in normal-weight individuals. Am J Clin Nutr 94:410–416
Stoohs RA, Facchini FS, Philip P, Valencia-Flores M, Guilleminault C (1993) Selected cardiovascular risk factors in patients with obstructive sleep apnea: effect of nasal continuous positive airway pressure (n-CPAP). Sleep 16:S141–S142
Szentirmai E, Hajdu I, Obal F Jr, Krueger JM (2006) Ghrelin-induced sleep responses in ad libitum fed and food-restricted rats. Brain Res 1088:131–140
Szentirmai E, Kapas L, Krueger JM (2007) Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats. Am J Physiol 292:R575–R585
Taheri S, Lin L, Austin D, Young T, Mignot E (2004) Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med 1:e62
Tasali E, Ip MS (2008) Obstructive sleep apnea and metabolic syndrome: alterations in glucose metabolism and inflammation. Proc Am Thorac Soc 5:207–217
Tasali E, Leproult R, Ehrmann DA, Van Cauter E (2008) Slow-wave sleep and the risk of type 2 diabetes in humans. Proc Natl Acad Sci USA 105:1044–1049
Tasali E, Mokhlesi B, Van Cauter E (2008) Obstructive sleep apnea and type 2 diabetes: interacting epidemics. Chest 133:496–506
Tasali E, Leproult R, Spiegel K (2009) Reduced sleep duration or quality: relationships with insulin resistance and type 2 diabetes. Prog Cardiovasc Dis 51:381–391
Tasali E, Broussard J, Day A, Kilkus J, Van Cauter E (2009) Sleep curtailment in healthy young adults is associated with increased ad lib food intake. In: 23rd Annual Meeting of the Associated Professional Sleep Societies, Vol. Sleep 32 Suppl. S Abstract 394 A131–A131, Seattle, WA, USA
Tasali E, Chapotot F, Leproult R, Whitmore H, Ehrmann DA (2011) Treatment of obstructive sleep apnea improves cardiometabolic function in young obese women with polycystic ovary syndrome. J Clin Endocrinol Metabol 96:365
Teramoto S et al (2008) Cardiovascular and metabolic effects of CPAP in obese obstructive sleep apnoea patients. Eur Respir J 31:223
Theorell-Haglow J, Berne C, Janson C, Sahlin C, Lindberg E (2010) Associations between short sleep duration and central obesity in women. Sleep 33:593–598
Thomas M et al (2000) Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity. J Sleep Res 9:335–352
Tomfohr LM, Edwards KM, Dimsdale JE (2011) Is obstructive sleep apnea associated with cortisol levels? A systematic review of the research evidence. Sleep Med Rev. doi:10.1016/j.smrv.2011.05.003
Trenell MI et al (2007) Influence of constant positive airway pressure therapy on lipid storage, muscle metabolism and insulin action in obese patients with severe obstructive sleep apnoea syndrome. Diabetes Obes Metab 9:679–687
Van Cauter E (2005) Endocrine physiology. In: Kryger M, Roth T, Dement WC (eds) Principles and practice of sleep medicine, 4th edn. Elsevier-Saunders, Philadelphia
Van Cauter E et al (1991) Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep. J Clin Invest 88:934–942
Van Cauter E et al (1992) A quantitative estimation of growth hormone secretion in normal man: reproducibility and relation to sleep and time of day. J Clin Endocrinol Metabol 74:1441–1450
Van Cauter E, Polonsky KS, Scheen AJ (1997) Roles of circadian rhythmicity and sleep in human glucose regulation. Endocr Rev 18:716–738
van den Berg JF et al (2008) Actigraphic sleep duration and fragmentation are related to obesity in the elderly: the Rotterdam Study. Int J Obes 32:1083–1090
van der Lely AJ (2009) Ghrelin and new metabolic frontiers. Horm Res 71(Suppl 1):129–133
van der Lely AJ, Tschop M, Heiman ML, Ghigo E (2004) Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25:426–457
van Dijk G (2001) The role of leptin in the regulation of energy balance and adiposity. J Neuroendocrinol 13:913–921
van Leeuwen WM et al (2010) Prolonged sleep restriction affects glucose metabolism in healthy young men. Int J Endocrinol 2010:108641
VanHelder T, Symons JD, Radomski MW (1993) Effects of sleep deprivation and exercise on glucose tolerance. Aviat Space Environ Med 64:487–492
Vgontzas AN, Bixler EO (2008) Short sleep and obesity: are poor sleep, chronic stress, and unhealthy behaviors the link? Sleep 31:1203
Vgontzas A et al (2007) Hypothalamic–pituitary–adrenal axis activity in obese men with and without sleep apnea: effects of continuous positive airway pressure therapy. J Clin Endocrinol Metabol 92:4199
Vgontzas AN et al (2008) Short sleep duration and obesity: the role of emotional stress and sleep disturbances. Int J Obes 32:801–809
Vgontzas A, Zoumakis E, Bixler E, Lin H (2008) Selective effects of CPAP on sleep apnoea associated manifestations. Eur J Clin Invest 38:585–595
Vondra K et al (1981) Effects of sleep deprivation on the activity of selected metabolic enzymes in skeletal muscle. Eur J Appl Physiol Occup Physiol 47:41–46
Wallace TM, Levy JC, Matthews DR (2004) Use and abuse of HOMA modeling. Diabetes Care 27:1487
Watanabe M, Kikuchi H, Tanaka K, Takahashi M (2010) Association of short sleep duration with weight gain and obesity at 1-year follow-up: a large-scale prospective study. Sleep 33:161–167
Weaver TE et al (1997) An instrument to measure functional status outcomes for disorders of excessive sleepiness. Sleep 20:835–843
Wehrens SM, Hampton SM, Finn RE, Skene DJ (2010) Effect of total sleep deprivation on postprandial metabolic and insulin responses in shift workers and non-shift workers. J Endocrinol 206:205–215
Wei CY et al (2009) Effects of continuous positive airway pressure upon 24 h changes of blood glucose level in patients with obstructive sleep apnea hypopnea syndrome and type 2 diabetes. Zonghua Yi Xue Yi Chuan Xue Za Zi 89:2686–2689
West SD, Nicoll DJ, Wallace TM, Matthews DR, Stradling JR (2007) Effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes. Thorax 62:969
White DP, Weil JV, Zwillich CW (1985) Metabolic rate and breathing during sleep. J Appl Physiol 59:384–391
Willett WC et al (1995) Weight, weight change, and coronary heart disease in women. Risk within the ‘normal’ weight range. JAMA 273:461–465
Williams CJ, Hu FB, Patel SR, Mantzoros CS (2007) Sleep duration and snoring in relation to biomarkers of cardiovascular disease risk among women with type 2 diabetes. Diabetes Care 30:1233–1240
Wilson DF (2011) Measuring in vivo metabolite levels in brain. Sleep 34:837, author reply 841–833
Wong-Riley M (2011) What is the meaning of the ATP surge during sleep? Sleep 34:833–834, author reply 841–833
Wu MF, John J, Maidment N, Lam HA, Siegel JM (2002) Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement. Am J Physiol 283:R1079–R1086
Xiang AH et al (2006) Effect of pioglitazone on pancreatic beta-cell function and diabetes risk in Hispanic women with prior gestational diabetes. Diabetes 55:517–522
Yki-Järvinen H (2004) Thiazolidinediones. N Eng J Med 351:1106–1118
Young T, Peppard PE, Taheri S (2005) Excess weight and sleep-disordered breathing. J Appl Physiol 99:1592–1599
Zeitzer JM, Buckmaster CL, Lyons DM, Mignot E (2007) Increasing length of wakefulness and modulation of hypocretin-1 in the wake-consolidated squirrel monkey. Am J Physiol 293:R1736–R1742
Zielinski MR, Kline CE, Kripke DF, Bogan RK, Youngstedt SD (2008) No effect of 8-week time in bed restriction on glucose tolerance in older long sleepers. J Sleep Res 17:412–419
Acknowledgments
Some of the research described in this article was supported by US National Institute of Health grants P01 AG-11412, R01 HL-075079, P60 DK-20595, R01 DK-0716960, R01 HL-075025, and M01 RR000055, by US Department of Defense award W81XWH-07-2-0071, by Belgian “Fonds de la Recherche Scientifique Médicale” (FRSM-3.4583.02), “Fonds National de la Recherche Scientifique” (FNRS) and “CARE Foundation” grants, by INSERM U628, and by Claude Bernard University of Lyon, France.
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Morselli, L.L., Guyon, A. & Spiegel, K. Sleep and metabolic function. Pflugers Arch - Eur J Physiol 463, 139–160 (2012). https://doi.org/10.1007/s00424-011-1053-z
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DOI: https://doi.org/10.1007/s00424-011-1053-z