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Cerebral amyloid angiopathy in aged Chinese: a clinico-neuropathological study

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Abstract

To investigate the prevalence and clinico-neuropathological characteristics of cerebral amyloid angiopathy (CAA) in aged Chinese and its relationship to dementia and cerebrovascular lesions, we examined 362 archived brains of elderly with immunohistochemical staining for β-amyloid peptide and Congo red, Bodian and Luxol fast blue stains. We found that: (1) CAA appeared in 31.7% examined brains without sexual preponderance, and the incidence increased with age; (2) the frontal lobe was most frequently involved in CAA, followed by occipital and parietal lobe; (3) subcortical white matter and cerebellum dentate nucleus areas may also be affected by CAA; (4) CAA has a close relationship to Alzheimer's disease and multiple cerebrovascular lesions; (5) CAA alone may result in dementia.

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Acknowledgement

This work was supported by a grant from the Major State Basic Research Development Program of China (973 Program) (No. G2000057005)

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Authors and Affiliations

  1. Department of Geriatric Neurology, Chinese PLA General Hospital, 28 Fuxing Road, 100853, Beijing, P.R. China

    Dan Xu, Chunhui Yang & Luning Wang

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  1. Dan Xu
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  2. Chunhui Yang
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  3. Luning Wang
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Correspondence to Luning Wang.

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Xu, D., Yang, C. & Wang, L. Cerebral amyloid angiopathy in aged Chinese: a clinico-neuropathological study. Acta Neuropathol 106, 89–91 (2003). https://doi.org/10.1007/s00401-003-0706-1

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  • DOI: https://doi.org/10.1007/s00401-003-0706-1

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