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Prediction of histology and invasive depth of colorectal neoplasia based on morphology of surface depression using magnifying chromocolonoscopy

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Background and study aims

Estimation of histology and depth of invasion in early colorectal neoplasia is essential for patient treatment. We therefore conducted a prospective study to examine whether the morphology of depression area contained at the surface of colorectal neoplasia can be used for predicting the histology and invasive depth.

Methods

A series of 228 consecutive patients with 296 colorectal lesions were studied. All lesions were evaluated by magnifying chromocolonoscopy. Surface depression contained in the lesions was noted and the depressive morphology was further divided into two subgroups of type I and type II. All of the lesions were resected endoscopically or surgically and examined histologically for comparison.

Results

A total of 296 lesions were evaluated, of which 66 (22.3%) contained an area of central depression, including 43 in nonpolypoid (flat and depressed) lesions (66%) and 23 in polypoid (10%). The overall accuracy of depressive morphology for distinction between low-grade dysplasia and high-grade dysplasia/invasive cancer, and between m-sm1 and sm2-sm3 was 86.4% and 84.8%, respectively.

Conclusions

Depression was predominantly contained in nonpolypoid colorectal neoplasia. Morphology of depression observed by magnifying chromocolonoscopy could be used as a complementary method to assess the degree of atypia and invasive depth in colorectal neoplasia.

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Authors and Affiliations

  1. Department of Gastroenterology, Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Disease, 145 Shan-dong zhong Rd., Shanghai, 200001, China

    Xiaobo Li, Huimin Chen, Yunjie Gao, Xiaoyu Chen & Zhizheng Ge

Authors
  1. Xiaobo Li
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  2. Huimin Chen
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  3. Yunjie Gao
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  4. Xiaoyu Chen
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  5. Zhizheng Ge
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Corresponding author

Correspondence to Zhizheng Ge.

Additional information

This work was supported by a grant from the Shanghai Leading Academic Discipline Project (No. Y0205). All doctors have no potential conflicts of interest.

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Li, X., Chen, H., Gao, Y. et al. Prediction of histology and invasive depth of colorectal neoplasia based on morphology of surface depression using magnifying chromocolonoscopy. Int J Colorectal Dis 25, 79–85 (2010). https://doi.org/10.1007/s00384-009-0821-0

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  • DOI: https://doi.org/10.1007/s00384-009-0821-0

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