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Transient Receptor Potential (TRP) channels in T cells

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Abstract

The transient receptor potential (TRP) family of ion channels is widely expressed in many cell types and plays various physiological roles. Growing evidence suggests that certain TRP channels are functionally expressed in the immune system. Indeed, an increasing number of reports have demonstrated the functional expression of several TRP channels in innate and adaptive immune cells and have highlighted their critical role in the activation and function of these cells. However, very few reviews have been entirely dedicated to this subject. Here, we will summarize the recent findings with regards to TRP channel expression in T cells and discuss their emerging role as regulators of T cell activation and functions. Moreover, these studies suggest that beyond their pharmaceutical interest in pain management, certain TRP channels may represent potential novel therapeutic targets for various immune-related diseases.

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Acknowledgments

We apologize to the colleagues whose work could not be cited due to space limitations or may have been omitted. We thank Hannah Federman for proofreading the manuscript. This work was supported by a grant from the NIH (U01 AI095623), an award to E.R. from the Crohn’s and Colitis Foundation of America (CCFA) (SRA#330251), and a research fellowship to S.B. from the CCFA (RFA#3574).

Authors’ contribution

S.B. and E.R. wrote this review.

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  1. Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0663, USA

    Samuel Bertin & Eyal Raz

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  1. Samuel Bertin
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  2. Eyal Raz
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Correspondence to Samuel Bertin.

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This article is a contribution to the special issue on the Role of TRP Ion Channels in Physiology and Pathology - Guest Editor: Armen Akopian

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Bertin, S., Raz, E. Transient Receptor Potential (TRP) channels in T cells. Semin Immunopathol 38, 309–319 (2016). https://doi.org/10.1007/s00281-015-0535-z

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