Abstract
Paranasal sinus cancer is a very rare disease. The literature contains numerous small retrospective reports describing the treatment and outcome of these patients. The comparison of patient outcome both within and between these reports is hampered by patient heterogeneity. We have outlined some of the caveats to be kept in mind when interpreting this literature and described some of the resultant controversies. The failure to achieve local control of advanced disease remains a major problem. Strategies for improvement of local control will include advanced surgical techniques with radiation dose escalation using state-of-the-art, high-precision delivery techniques accompanied by concurrent cytotoxic and/or biologic therapies. The ideal integration of surgery and radiation remains to be defined in the context of contemporary treatment approaches designed to achieve optimum local control and organ preservation.
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References
M Kondo K Ogawa Y Inuyama et al. (1985) ArticleTitlePrognostic factors influencing relapse of squamous cell carcinoma of the maxillary sinus Cancer 55 190–196 Occurrence Handle1:STN:280:BiqD2szps1M%3D Occurrence Handle3965080
SP Giri EK Reddy LS Gemer et al. (1992) ArticleTitleManagement of advanced squamous cell carcinomas of the maxillary sinus Cancer 69 657–661 Occurrence Handle1:STN:280:By2C3M%2FntFw%3D Occurrence Handle1730116
I Alvarez C Suarez JP Rodrigo et al. (1995) ArticleTitlePrognostic factors in paranasal sinus cancer Am. J. Otolaryngol. 16 109–114
J Waldron B O’Sullivan B Cummings et al. (1996) ArticleTitleParanasal sinus cancer: a retrospective analysis of 180 cases managed at a single institution. 10th Annual Scientific Meeting, Canadian Association of Radiation Oncologists Clin. Invest. Med. 19 S83
QT Le KK Fu M Kaplan et al. (1999) ArticleTitleTreatment of maxillary sinus carcinoma: a comparison of the 1997 and 1977 American Joint Committee on cancer staging systems Cancer 86 1700–1711 Occurrence Handle10.1002/(SICI)1097-0142(19991101)86:9<1700::AID-CNCR11>3.3.CO;2-W Occurrence Handle1:STN:280:DC%2BD3c%2Fhs1aqtQ%3D%3D Occurrence Handle10547542
LG Ohngren (1933) ArticleTitleMalignant tumours of the maxillo-ethmoidal region Acta Otolaryngol. Suppl. 19 101–106
M Lederman (1970) ArticleTitleTumours of the upper jaw: natural history and treatment J. Laryngol. Otol. 84 369–401 Occurrence Handle1:STN:280:CS%2BC28rotlw%3D Occurrence Handle5440664
S Sakai Y Hamasaki (1967) ArticleTitleProposal for the classification of carcinoma of the paranasal sinuses Acta Otolaryngol. (Stockh). 63 42–48 Occurrence Handle1:STN:280:CCiB3c7ms1Y%3D
F Carinci A Farina E Padula et al. (1997) ArticleTitlePrimary malignancies of the nasal fossa and paranasal sinuses: comparison between UICC classification and a new staging system J. Craniofac. Surg. 8 405–412 Occurrence Handle1:STN:280:DyaK1c7ktlSrsA%3D%3D Occurrence Handle9482083
G Cantu CL Solero L Mariani et al. (1999) ArticleTitleA new classification for malignant tumors involving the anterior skull base Arch. Otolaryngol. Head Neck Surg. 125 1252–1257 Occurrence Handle1:STN:280:DC%2BD3c%2Fit1Khtg%3D%3D Occurrence Handle10555698
ID Flemming JS Cooper DE Henson (Eds) et al. (1997) Cancer Staging Manual AJCC EditionNumber5th edition Lippincott Philadelphia
LH Sobin C Wittekind (1997) UICC TNM Classification of Malignant Tumours EditionNumber5th edition Lippincott Philadelphia
JR Chandler OM Guillamondegui GA Sisson et al. (1976) ArticleTitleClinical staging of cancer of the head and neck: a new “new” system Am. J. Surg. 132 525–528 Occurrence Handle1:STN:280:CSiC3cblt1E%3D Occurrence Handle1015544
JN Waldron B Os P Warde et al. (1998) ArticleTitleEthmoid sinus cancer: twenty-nine cases managed with primary radiation therapy Int. J. Radiat. Oncol. Biol. Phys. 41 361–369 Occurrence Handle10.1016/S0360-3016(98)00018-2 Occurrence Handle1:STN:280:DyaK1c3mvVelug%3D%3D Occurrence Handle9607352
PJ Gullane J Conley (1983) ArticleTitleCarcinoma of the maxillary sinus. A correlation of the clinical course with orbital involvement, pterygoid erosion or pterygopalatine invasion and cervical metastases J. Otolaryngol. 12 141–145
PE Robin DJ Powell (1980) ArticleTitleRegional node involvement and distant metastases in carcinoma of the nasal cavity and paranasal sinuses J. Laryngol. Otol. 94 301–309 Occurrence Handle1:STN:280:Bi%2BC1czmvFE%3D Occurrence Handle7373133
AJ Neal F Habib HF Hope-Stone (1992) ArticleTitleCarcinoma of the maxillary antrum treated by pre-operative radiotherapy or radical radiotherapy alone J. Laryngol. Otol. 106 1063–1066 Occurrence Handle1:STN:280:ByyC3sbmsFU%3D Occurrence Handle1487661
AR Feinstein DM Sosin CK Wells (1985) ArticleTitleThe Will Rogers phenomenon. Stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer N. Engl. J. Med. 312 1604–1608 Occurrence Handle1:STN:280:BiqB3MzntVE%3D Occurrence Handle4000199
M Kondo Y Ando Y Inuyama et al. (1986) ArticleTitleMaxillary squamous cell carcinomas staged by computed tomography Int. J. Radiat. Oncol. Biol. Phys. 12 111–116 Occurrence Handle1:STN:280:BimC3M7itlY%3D Occurrence Handle3943982
R Maroldi D Farina G Battaglia et al. (1997) ArticleTitleMR of malignant nasosinusal neoplasms. Frequently asked questions Eur. J. Radiol. 24 181–190 Occurrence Handle10.1016/S0720-048X(97)01183-2 Occurrence Handle1:STN:280:ByiA2snisFc%3D Occurrence Handle9232389
G Harbo C Grau T Bundgaard et al. (1997) ArticleTitleCancer of the nasal cavity and paranasal sinuses. A clinico- pathological study of 277 patients Acta Oncol. 36 45–50 Occurrence Handle1:STN:280:ByiB38jptFA%3D Occurrence Handle9090965
NJ Slevin CD Collins DL Hastings et al. (1999) ArticleTitleThe diagnostic value of positron emission tomography (PET) with radiolabelled fluorodeoxyglucose (18F-FDG) in head and neck cancer J. Laryngol. Otol. 113 548–554 Occurrence Handle1:STN:280:DC%2BD3c%2FntlGiuw%3D%3D Occurrence Handle10605586
PE Robin DJ Powell (1981) ArticleTitleDiagnostic errors in cancers of the nasal cavity and paranasal sinuses. The essential role of surgery Arch. Otolaryngol. 107 138–140 Occurrence Handle1:STN:280:Bi6C3szgslE%3D Occurrence Handle7469899
JP Logue NJ Slevin (1991) ArticleTitleCarcinoma of the nasal cavity and paranasal sinuses: an analysis of radical radiotherapy Clin. Oncol. 3 84–89 Occurrence Handle1:STN:280:By6B3svmslw%3D
JT Parsons FC Kimsey WM Mendenhall et al. (1995) ArticleTitleRadiation therapy for sinus malignancies Otolaryngol. Clin. North Am. 28 1259–1268 Occurrence Handle1:STN:280:BymH3c3hsFM%3D Occurrence Handle8927396
TO Truitt LL Gleich GP Huntress et al. (1999) ArticleTitleSurgical management of hard palate malignancies Otolaryngol. Head Neck Surg. 121 548–552 Occurrence Handle1:STN:280:DC%2BD3c%2Fhs1Cksg%3D%3D Occurrence Handle10547468
AL Weber AC Stanton (1984) ArticleTitleMalignant tumors of the paranasal sinuses: radiologic, clinical, and histopathologic evaluation of 200 cases Head Neck Surg. 6 761–776 Occurrence Handle1:STN:280:BiuC3M7gt1I%3D Occurrence Handle6319335
EH Hadfield RG Macbeth (1971) ArticleTitleAdenocarcinoma of ethmoids in furniture workers Ann. Otol. Rhinol. Laryngol. 80 699–703 Occurrence Handle1:STN:280:CS2D38%2FhtVM%3D Occurrence Handle5110879
C Klintenberg J Olofsson H Hellquist et al. (1984) ArticleTitleAdenocarcinoma of the ethmoid sinuses. A review of 28 cases with special reference to wood dust exposure Cancer 54 482–488 Occurrence Handle6733678
SH Saunders T Ruff (1976) ArticleTitleAdenocarcinoma of the para-nasal sinuses J. Laryngol. Otol. 90 157–166 Occurrence Handle1:STN:280:CSmC387ls1I%3D Occurrence Handle1249494
PP Knegt PC Jong Particlede JG Andel Particlevan et al. (1985) ArticleTitleCarcinoma of the paranasal sinuses. Results of a prospective pilot study Cancer 56 57–62 Occurrence Handle1:STN:280:BiqB38josFU%3D Occurrence Handle4005793
AS Jones JW Hamilton H Rowley et al. (1997) ArticleTitleAdenoid cystic carcinoma of the head and neck Clin. Otolaryngol. 22 434–443 Occurrence Handle1:STN:280:DyaK1c%2FjvFGhtg%3D%3D Occurrence Handle9372255
GE Kim HC Park KC Keum et al. (1999) ArticleTitleAdenoid cystic carcinoma of the maxillary antrum Am. J. Otolaryngol. 20 77–84
S Naficy MJ Disher RM Esclamado (1999) ArticleTitleAdenoid cystic carcinoma of the paranasal sinuses Am. J. Rhinol. 13 311–314 Occurrence Handle1:STN:280:DyaK1MvhsVKktw%3D%3D Occurrence Handle10485019
PA Levine H Frierson SuffixJr FM Stewart et al. (1987) ArticleTitleSinonasal undifferentiated carcinoma: a distinctive and highly aggressive neoplasm Laryngoscope 97 905–908
GD Houston E Gillies (1999) ArticleTitleSinonasal undifferentiated carcinoma: a distinctive clinicopathologic entity Adv. Anat. Pathol. 6 317–323 Occurrence Handle1:STN:280:DC%2BD3c%2FivVKgsQ%3D%3D Occurrence Handle10562893
P Lavertu JK Roberts DH Kraus et al. (1989) ArticleTitleSquamous cell carcinoma of the paranasal sinuses: the Cleveland Clinic experience 1977-1986 Laryngoscope 99 1130–1136
MH Jakobsen SK Larsen J Kirkegaard et al. (1997) ArticleTitleCancer of the nasal cavity and paranasal sinuses. Prognosis and outcome of treatment Acta Oncol. 36 27–31 Occurrence Handle1:STN:280:ByiB38jptFQ%3D Occurrence Handle9090960
AJ Curran PJ Gullane J Waldron et al. (1998) ArticleTitleSurgical salvage after failed radiation for paranasal sinus malignancy Laryngoscope 108 1618–1622
BJ Haylock DG John IC Paterson (1991) ArticleTitleThe treatment of squamous cell carcinoma of the paranasal sinuses Clin. Oncol. 3 17–21 Occurrence Handle1:STN:280:By6C2MbitVI%3D
AW Pearlman R Abadir (1974) ArticleTitleCarcinoma of maxillary antrum: the role of pre-operative irradiation Laryngoscope 84 400–409
JA Purdy (1999) ArticleTitle3D treatment planning and intensity-modulated radiation therapy Oncology Huntingt. 13 155–168 Occurrence Handle1:STN:280:DC%2BD3c%2FhvVGjtg%3D%3D Occurrence Handle10550841
TR Mackie J Balog K Ruchala et al. (1999) ArticleTitleTomotherapy Semin. Radiat. Oncol. 9 108–117 Occurrence Handle1:STN:280:DyaK1M3hsVKnug%3D%3D
G Sisson SuffixSr DM Toriumi RA Atiyah (1989) ArticleTitleParanasal sinus malignancy: a comprehensive update Laryngoscope 99 143–150
JD Osguthorpe (1994) ArticleTitleSinus neoplasia Arch. Otolaryngol. Head Neck Surg. 120 19–25 Occurrence Handle1:STN:280:ByuD1Mbpt1c%3D Occurrence Handle8274251
S Yoza H Gunji I Ono (1997) ArticleTitlePrimary maxillary reconstruction after radical maxillectomy using a combined free flap and secondary dynamic suspension J. Craniofac. Surg. 8 65–73 Occurrence Handle1:STN:280:DyaK1M3msVOjtA%3D%3D Occurrence Handle10332302
S Kyutoku H Tsuji T Inoue et al. (1999) ArticleTitleExperience with the rectus abdominis myocutaneous flap with vascularized hard tissue for immediate orbitofacial reconstruction Plast. Reconstr. Surg. 103 395–402 Occurrence Handle1:STN:280:DyaK1M7jsVSmug%3D%3D Occurrence Handle9950524
M Hochman (1995) ArticleTitleReconstruction of midfacial and anterior skull-base defects Otolaryngol. Clin. North Am. 28 1269–1277 Occurrence Handle1:STN:280:BymH3c3hsFw%3D Occurrence Handle8927397
IP Janecka C Sen L Sekhar et al. (1994) ArticleTitleTreatment of paranasal sinus cancer with cranial base surgery: results Laryngoscope 104 553–555
A Blokmanis (1994) ArticleTitleEndoscopic diagnosis, treatment, and follow-up of tumours of the nose and sinuses J. Otolaryngol. 23 366–369
M Jorissen (1995) ArticleTitleThe role of endoscopy in the management of paranasal sinus tumours Acta Otorhinolaryngol. Belg. 49 225–228 Occurrence Handle1:STN:280:BymD2c3mslw%3D Occurrence Handle7484140
K Ikeda H Suzuki T Oshima et al. (1998) ArticleTitleMidfacial degloving approach facilitated by endoscope to the sinonasal malignancy Auris. Nasus. Larynx 25 289–293
HF Sailer PE Haers KW Gratz (1999) ArticleTitleThe Le Fort I osteotomy as a surgical approach for removal of tumours of the midface J. Craniomaxillofac. Surg. 27 1–6 Occurrence Handle1:STN:280:DyaK1M3gtl2gtw%3D%3D Occurrence Handle10188120
J Raveh K Laedrach M Speiser et al. (1993) ArticleTitleThe subcranial approach for fronto-orbital and anteroposterior skull-base tumors Arch. Otolaryngol. Head Neck Surg. 119 385–393 Occurrence Handle1:STN:280:ByyB3cjntVY%3D Occurrence Handle8457302
IE McCutcheon JB Blacklock RS Weber et al. (1996) ArticleTitleAnterior transcranial (craniofacial) resection of tumors of the paranasal sinuses: surgical technique and results Neurosurgery 38 471–479 Occurrence Handle1:STN:280:BymH3svptFY%3D Occurrence Handle8837798
JP Shah DH Kraus (1992) ArticleTitleArbit Eea. Craniofacial resection for tumors involving the anterior skull base Otolaryngol. Head Neck Surg. 106 386–393
G Cantu CL Solero L Mariani et al. (1999) ArticleTitleAnterior craniofacial resection for malignant ethmoid tumors—a series of 91 patients Head Neck 21 185–191 Occurrence Handle10.1002/(SICI)1097-0347(199905)21:3<185::AID-HED1>3.3.CO;2-# Occurrence Handle1:STN:280:DyaK1M3itlemug%3D%3D Occurrence Handle10208659
MJ Rutter CE Furneaux RP Morton (1998) ArticleTitleCraniofacial resection of anterior skull base tumours: factors contributing to success Aust. N. Z. J. Surg. 68 350–353 Occurrence Handle1:STN:280:DyaK1c3ptlKluw%3D%3D Occurrence Handle9631908
MK Wax KJ Yun SJ Wetmore et al. (1995) ArticleTitleAdenocarcinoma of the ethmoid sinus Head Neck 17 303–311 Occurrence Handle1:STN:280:ByqH3czhsVQ%3D Occurrence Handle7672971
F Mouriaux V Martinot P Pellerin et al. (1999) ArticleTitleSurvival after malignant tumors of the orbit and periorbit treated by exenteration Acta Ophthalmol. Scand. 77 326–330 Occurrence Handle1:STN:280:DyaK1Mzjt1Orug%3D%3D Occurrence Handle10406155
SD Stavrianos IG Camilleri NR McLean et al. (1998) ArticleTitleMalignant tumours of the maxillary complex: an 18-year review Br. J. Plast. Surg. 51 584–588 Occurrence Handle10.1054/bjps.1998.0298 Occurrence Handle1:STN:280:DyaK1M3isF2gtg%3D%3D Occurrence Handle10209459
KT Pitman EP Prokopakis B Aydogan et al. (1999) ArticleTitleThe role of skull base surgery for the treatment of adenoid cystic carcinoma of the sinonasal tract Head Neck 21 402–407 Occurrence Handle10.1002/(SICI)1097-0347(199908)21:5<402::AID-HED4>3.0.CO;2-Z Occurrence Handle1:STN:280:DyaK1Mzjt1akuw%3D%3D Occurrence Handle10402519
MH Bilsky DH Kraus EW Strong et al. (1997) ArticleTitleExtended anterior craniofacial resection for intracranial extension of malignant tumors Am. J. Surg. 174 565–568 Occurrence Handle10.1016/S0002-9610(97)00172-4 Occurrence Handle1:STN:280:DyaK1c%2FktVeqtw%3D%3D Occurrence Handle9374239
VJ Lund DJ Howard WI Wei et al. (1998) ArticleTitleCraniofacial resection for tumors of the nasal cavity and paranasal sinuses—a 17-year experience Head Neck 20 97–105 Occurrence Handle10.1002/(SICI)1097-0347(199803)20:2<97::AID-HED1>3.0.CO;2-Y Occurrence Handle1:STN:280:DyaK1c7ktlCksg%3D%3D Occurrence Handle9484939
HD Curtin JD Rabinov (1998) ArticleTitleExtension to the orbit from paraorbital disease. The sinuses Radiol. Clin. North Am. 36 1201–1213 Occurrence Handle1:STN:280:DyaK1M7gtVCgtw%3D%3D Occurrence Handle9884697
C Perry PA Levine BR Williamson et al. (1988) ArticleTitlePreservation of the eye in paranasal sinus cancer surgery Arch. Otolaryngol. Head Neck Surg. 114 632–634 Occurrence Handle1:STN:280:BieB3cbjtFc%3D Occurrence Handle2835065
ML Som (1974) ArticleTitleSurgical managment of carcinoma of the maxilla Arch. Otolaryngol. 99 270–273 Occurrence Handle1:STN:280:CSuC38jms1w%3D Occurrence Handle4206382
W Xuexi T Pingzhang Q Yongfa (1995) ArticleTitleManagment of the orbital contents in radical surgery for squamous cell carcinoma of the maxillary sinus Chin. Med. J. (Engl). 108 123–125
R Carrau E Myers (1998) Neoplasms of the nose and paranasal sinuses B Bailey K Calhoun (Eds) Head and Neck Surgery―Otolaryngology EditionNumber2nd edition Lippincott-Raven Philadelphia 1445–1469
R Tiwari J Wal Particlevan der I Waal Particlevan der et al. (1998) ArticleTitleStudies of the anatomy and pathology of the orbit in carcinoma of the maxillary sinus and their impact on preservation of the eye in maxillectomy Head Neck 20 193–196 Occurrence Handle10.1002/(SICI)1097-0347(199805)20:3<193::AID-HED2>3.3.CO;2-5 Occurrence Handle1:STN:280:DyaK1c3jtVGmsg%3D%3D Occurrence Handle9570623
WS McCary PA Levine RW Cantrell (1996) ArticleTitlePreservation of the eye in the treatment of sinonasal malignant neoplasms with orbital involvement. A confirmation of the original treatise Arch. Otolaryngol. Head Neck Surg. 122 657–659 Occurrence Handle1:STN:280:BymB2c%2Fis1c%3D Occurrence Handle8639299
SJ Stern H Goepfert G Clayman et al. (1993) ArticleTitleSquamous cell carcinoma of the maxillary sinus Arch. Otolaryngol. Head Neck Surg. 119 964–969 Occurrence Handle1:STN:280:ByyA28zjt1Q%3D Occurrence Handle8357597
GL Jiang KK Ang LJ Peters et al. (1991) ArticleTitleMaxillary sinus carcinomas: natural history and results of postoperative radiotherapy Radiother. Oncol. 21 193–200 Occurrence Handle1:STN:280:By2D387ls10%3D Occurrence Handle1924855
AC Paulino SG Fisher JE Marks (1997) ArticleTitleIs prophylactic neck irradiation indicated in patients with squamous cell carcinoma of the maxillary sinus? Int. J. Radiat. Oncol. Biol. Phys. 39 283–289 Occurrence Handle10.1016/S0360-3016(97)00293-9 Occurrence Handle1:STN:280:ByiH2M3ltFE%3D Occurrence Handle9308929
H Tsujii T Kamada T Arimoto et al. (1986) ArticleTitleThe role of radiotherapy in the management of maxillary sinus carcinoma Cancer 57 2261–2266 Occurrence Handle1:STN:280:BimC1cbktlA%3D Occurrence Handle3697928
KT Robbins P Kumar WF Regine et al. (1997) ArticleTitleEfficacy of targeted supradose cisplatin and concomitant radiation therapy for advanced head and neck cancer: the Memphis experience Int. J. Radiat. Oncol. Biol. Phys. 38 263–271 Occurrence Handle10.1016/S0360-3016(97)00092-8 Occurrence Handle1:CAS:528:DyaK2sXltFKhu7c%3D Occurrence Handle9226312
J Bourhis JP Pignon (1999) ArticleTitleMetaanalyses in head and neck squamous cell carcinoma. What is the role of chemotherapy? Hematol. Oncol. Clin. North Am. 13 769–775
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Waldron, J., Witterick, I. Paranasal Sinus Cancer: Caveats and Controversies. World J. Surg. 27, 849–855 (2003). https://doi.org/10.1007/s00268-003-7111-8
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DOI: https://doi.org/10.1007/s00268-003-7111-8