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Comorbidity and mortality after hip fracture in nineteen thousand six hundred and eighty two patients aged eighteen to sixty five years in Denmark from 1996 to 2012

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Abstract

Purpose

This nationwide study assessed associations between comorbidity and mortality after hip fracture in young and middle-aged patients.

Methods

Data on 19,682 patients aged 18 to 65 years were extracted from Danish registries out of 154,047 patients who experienced a hip fracture between 1996 and 2012. Mortality and comorbidity were assessed using information on vital status, hospital admissions, and prescriptions.

Results

Of the 19,682 patients 17,722 (90.0%) were middle-aged (40–65 years) and 1960 (10.0%) were young (18–39 years). The 30-day mortality rates were 3.2% (n = 570) and 1.6% (n = 32), respectively. Indicators of multi-trauma (hazard ratio (HR), 3.5 95% confidence interval (CI) [1.6–7.8], n = 2056) and having diabetes (HR, 4.4 [1.2–11.3], n = 59) and heart disease (HR, 4.4[1.3–14.8], n = 57) increased 30-day mortality in the young patients, while having cancer (HR, 5.0 [4.2–5.9], n = 1958) increased 30-day mortality in the middle-aged patients.

Conclusion

Heart disease and diabetes were associated with high mortality in the young patients while having cancer was associated with high mortality in the middle-aged patients.

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Abbreviations

HR:

Hazard ratio

CI:

Confidence interval

ICD-10:

International classification of diseases

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Author information

Authors and Affiliations

  1. Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark

    Adam Omari

  2. Department of Clinical Biochemistry, Herlev & Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

    Christian Medom Madsen

  3. Department of Orthopedic Surgery, Bispebjerg Frederiksberg Hospital, Copenhagen, Denmark

    Jes Bruun Lauritzen

  4. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

    Jes Bruun Lauritzen & Henrik Løvendahl Jørgensen

  5. Department of Clinical Biochemistry, Hvidovre Hospital, Hvidovre, Denmark

    Henrik Løvendahl Jørgensen

  6. Department of Clinical Biochemistry, Bispebjerg Frederiksberg Hospital, Copenhagen, Denmark

    Fie Juhl Vojdeman

Authors
  1. Adam Omari
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  2. Christian Medom Madsen
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  3. Jes Bruun Lauritzen
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  4. Henrik Løvendahl Jørgensen
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  5. Fie Juhl Vojdeman
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Corresponding author

Correspondence to Fie Juhl Vojdeman.

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Conflict of interests

The authors declare that they have no conflict of interest.

Ethical approval

According to Danish law, ethical committee approval is not required for this type of observational study. The data were obtained through secure remote access to Statistics Denmark (ref. 704670). The study was approved by the Danish Data Protection Agency (2012-58-0004)/local number BBH-2014-050.

Informed consent

For observational register-based studies, formal consent from patients is not required.

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Omari, A., Madsen, C.M., Lauritzen, J.B. et al. Comorbidity and mortality after hip fracture in nineteen thousand six hundred and eighty two patients aged eighteen to sixty five years in Denmark from 1996 to 2012. International Orthopaedics (SICOT) 43, 2621–2627 (2019). https://doi.org/10.1007/s00264-019-04323-z

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  • DOI: https://doi.org/10.1007/s00264-019-04323-z

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