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A prospective comparison between auto-registration and manual registration of real-time ultrasound with MR images for percutaneous ablation or biopsy of hepatic lesions

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Abstract

Purpose

To compare the accuracy and required time for image fusion of real-time ultrasound (US) with pre-procedural magnetic resonance (MR) images between positioning auto-registration and manual registration for percutaneous radiofrequency ablation or biopsy of hepatic lesions.

Methods

This prospective study was approved by the institutional review board, and all patients gave written informed consent. Twenty-two patients (male/female, n = 18/n = 4; age, 61.0 ± 7.7 years) who were referred for planning US to assess the feasibility of radiofrequency ablation (n = 21) or biopsy (n = 1) for focal hepatic lesions were included. One experienced radiologist performed the two types of image fusion methods in each patient. The performance of auto-registration and manual registration was evaluated. The accuracy of the two methods, based on measuring registration error, and the time required for image fusion for both methods were recorded using in-house software and respectively compared using the Wilcoxon signed rank test.

Results

Image fusion was successful in all patients. The registration error was not significantly different between the two methods (auto-registration: median, 3.75 mm; range, 1.0–15.8 mm vs. manual registration: median, 2.95 mm; range, 1.2–12.5 mm, p = 0.242). The time required for image fusion was significantly shorter with auto-registration than with manual registration (median, 28.5 s; range, 18–47 s, vs. median, 36.5 s; range, 14–105 s, p = 0.026).

Conclusion

Positioning auto-registration showed promising results compared with manual registration, with similar accuracy and even shorter registration time.

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Authors and Affiliations

  1. Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro Gangnam-gu, Seoul, 06351, South Korea

    Dong Ik Cha, Min Woo Lee & Kyoung Doo Song

  2. Medical Imaging R&D Group, Health & Medical Equipment Business, Samsung Electronics Co., Ltd., Seoul, South Korea

    Young-Taek Oh, Ja-Yeon Jeong, Jung-Woo Chang, Jiwon Ryu, Kyong Joon Lee, Jaeil Kim & Won-Chul Bang

  3. Infrastructure Technology Lab, R&D Center, Samsung Medison, Seoul, South Korea

    Dong Kuk Shin, Sung Jin Choi, Dalkwon Koh & Bong Koo Seo

  4. Biostatistics and Clinical Epidemiology Center, Samsung Medical Center, Seoul, South Korea

    Kyunga Kim

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  1. Dong Ik Cha
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Corresponding author

Correspondence to Min Woo Lee.

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Funding

This study was supported by Samsung Medison (Grant #PHO0132251).

Conflict of interest

Dong Kuk Shin, Sung Jin Choi, and Dalkwon Koh received support in the form of salaries from Samsung Medison. Min Woo Lee is a consultant for Samsung Medison. All other authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Electronic supplementary material

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Supplementary material 1 (DOCX 15 kb)

261_2017_1075_MOESM2_ESM.wmv

Supplementary Movie Positioning auto-registration between real-time US and pre-acquired MR images in a patient with hepatocellular carcinoma (same patient as in Fig. 4) (WMV 18247 kb)

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Cha, D.I., Lee, M.W., Song, K.D. et al. A prospective comparison between auto-registration and manual registration of real-time ultrasound with MR images for percutaneous ablation or biopsy of hepatic lesions. Abdom Radiol 42, 1799–1808 (2017). https://doi.org/10.1007/s00261-017-1075-x

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