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MR-Spektroskopie bei Demenz

MR spectroscopy in dementia

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Zusammenfassung

Angesichts einer immer älter werdenden Bevölkerung sind wir mit dem Problem einer zunehmenden Zahl an Demenzerkrankungen konfrontiert. Neben klinischen, neuropsychologischen und laborchemischen Verfahren spielt die MRT zur Frühdiagnostik einer Demenz eine wichtige Rolle. Morphologische Veränderungen wie auch verschiedene funktionelle Verfahren helfen bei der Diagnostik und Differenzialdiagnostik einer Demenz. Insgesamt kann mittels MR-spektroskopischer Parameter die Diagnostik einer Demenz verbessert werden. In diesem Artikel soll auf MR-spektroskopische Veränderungen im Rahmen des physiologischen Alterungsprozesses eingegangen werden. Ferner werden speziell Veränderungen bei leichter kognitiver Beeinträchtigung, einer Vorform der Alzheimer-Demenz, bei Alzheimer-, frontotemporaler, vaskulärer und Lewy-Körper-Demenz erörtert.

Abstract

With an increasingly aging population we are faced with the problem of an increasing number of dementia patients. In addition to clinical, neuropsychological and laboratory procedures, MRI plays an important role in the early diagnosis of dementia. In addition to various morphological changes functional changes can also help in the diagnosis and differential diagnosis of dementia. Overall the diagnosis of dementia can be improved by using parameters from MR spectroscopy. This article focuses on MR spectroscopic changes in the physiological aging process as well as on changes in mild cognitive impairment a precursor of Alzheimer’s dementia, in Alzheimer’s dementia, frontotemporal dementia, vascular dementia and Lewy body dementia.

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Authors and Affiliations

  1. Abteilung E010, Radiologie, Deutsches Krebsforschungszentrum (DKFZ) Heidelberg , Im Neuenheimer Feld 280, 69120, Heidelberg, Deutschland

    T. Hauser, L. Gerigk, F. Giesel, L. Schuster & M. Essig

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  1. T. Hauser
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  2. L. Gerigk
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  3. F. Giesel
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  4. L. Schuster
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  5. M. Essig
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Correspondence to T. Hauser.

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Hauser, T., Gerigk, L., Giesel, F. et al. MR-Spektroskopie bei Demenz. Radiologe 50, 791–798 (2010). https://doi.org/10.1007/s00117-009-1947-3

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  • DOI: https://doi.org/10.1007/s00117-009-1947-3

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