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Suppression of lymphocyte proliferation by a nonspecific factor produced by the burkitt lymphoma-derived lymphoblast cell line

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Summary

The DAUDI lymphoblast cell line derived from a patient with Burkitt lymphoma was obtained from two different sources. One of these (DAUDI-I) produced a factor that inhibited lymphocyte proliferation in both human and mouse regardless of the stimulator, i.e. allogeneic lymphocytes or mitogens. Glutaraldehyde treatment eliminated production of the factor and demonstrated that DAUDI-I was capable of stimulating normal lymphocytes in MLR. A second DAUDI cell line (DAUDI-S) did not produce the inhibitory factor and was capable of MLR stimulation.

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Authors and Affiliations

  1. Biochemistry Department, Wayne State University, School of Medicine, 540 E Canfield Street, 48201, Detroit, Michigan

    James J. Lightbody, Ward D. Peterson Jr. & M. D. Poulik

  2. Child Research Center of Michigan, Children's Hospital of Michigan, 48201, Detroit, Michigan

    James J. Lightbody, Ward D. Peterson Jr. & M. D. Poulik

  3. Department of Immunochemistry, William Beaumont Hospital, 48072, Royal Oak, Michigan

    James J. Lightbody, Ward D. Peterson Jr. & M. D. Poulik

Authors
  1. James J. Lightbody
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  2. Ward D. Peterson Jr.
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  3. M. D. Poulik
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Additional information

Supported by the Children's Leukemia Foundation of Michigan, NIH Grants AI 11013 and AI 11335, and the Kidney Foundation of Michigan.

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Lightbody, J.J., Peterson, W.D. & Poulik, M.D. Suppression of lymphocyte proliferation by a nonspecific factor produced by the burkitt lymphoma-derived lymphoblast cell line. In Vitro 14, 465–468 (1978). https://doi.org/10.1007/BF02616109

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