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A serological screening test for kidney damage

Spontaneous Tubular Damage in a Rat Discovered by Detection of Kidney Specific Antigens in the Urine

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Research in Experimental Medicine

Summary

Renal antigens were not detected, by immunodiffusion, in over 700 unconcentrated urine specimens, obtained from 119 control rats, when reacted with kidney specific antisera. Three consecutive urine samples of one rat contained renal antigens. Light and electron microscopic examination of the kidneys of this animal revealed proximal tubular damage. Detection of organ specific antigens in unconcentrated urine is a reliable index of tissue damage.

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References

  • Boss, J. H.: Arch. Path.76, 434–445 (1963).

    PubMed  Google Scholar 

  • Boss, J. H., Silber, E., Nelken, D.: Clin. exp. Immunol.2, 191–202 (1967).

    PubMed  Google Scholar 

  • Cruickshank, B., Hill, A. G. S.: J. Path. Bact.66, 283–289 (1953).

    PubMed  Google Scholar 

  • Dinh, B. L., Tremblay, A., Dufour, D.: J. Immunol.95, 574–582 (1965).

    PubMed  Google Scholar 

  • Dishon, T., Rosenmann, E., Durst, A., Boss, J. H.: Exp. molec. Path.15, 126–135 (1971).

    PubMed  Google Scholar 

  • Dishon, T., Durst, A., Rosenmann, E., Boss, J. H.: Invest. Urol.9, 438–442 (1972).

    PubMed  Google Scholar 

  • Durand, A. M. A., Disher, M., Adams, M.: Arch. Path.77, 268–277 (1964).

    PubMed  Google Scholar 

  • Elema, J. D., Koudstall, L., Lamberts, H. B., Arends, A.: Arch. Path.91, 418–425 (1971).

    PubMed  Google Scholar 

  • Laufer, A., Rosenmann, E., Davies, A. M.: Brit. J. exp. Path.47, 605–611 (1966).

    PubMed  Google Scholar 

  • Nairn, R. C., Ghose, T., Fothergill, J. E., McEntegart, M. G.: Nature (Lond.)196, 385–387 (1962).

    Google Scholar 

  • Perry, S. W.: J. Path. Bact.89, 729–733 (1965).

    PubMed  Google Scholar 

  • Rosenmann, E., Dishon, T., Boss, J. H.: J. Lab. clin. Med.74, 31–36 (1969).

    PubMed  Google Scholar 

  • Rosenmann, E., Dishon, T., Durst, A., Boss, J. H.: Brit. J. exp. Path.52, 388–394 (1971).

    PubMed  Google Scholar 

  • Rosenmann, E., Durst, A., Dishon, T., Boss, J. H.: Brit. J. Anaesth.44, 465–468 (1972).

    PubMed  Google Scholar 

  • Wexler, B. C., Kittinger, G. W.: J. Path. Bact.94, 231–246 (1967).

    Google Scholar 

  • Zbinden, G.: Experimental Renal Toxicity. In: Kidney-Morphology, Biochemistry, Physiology, Ed. by C. Rouiller and A. F. Muller, Vol. 2, pp. 401–475. New York-London: Academic Press 1969.

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology and Laboratory of Immunology (Faculty of Dental Medicine), Hebrew University Hadassah Medical School, B.o.B. 1172, Jerusalem, Israel

    E. Rosenmann, T. Dishon & J. H. Boss

Authors
  1. E. Rosenmann
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  2. T. Dishon
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  3. J. H. Boss
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Additional information

This investigation was supported by a grant from Nessim David Gaon from Geneva.

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Rosenmann, E., Dishon, T. & Boss, J.H. A serological screening test for kidney damage. Res. Exp. Med. 159, 35–43 (1972). https://doi.org/10.1007/BF01852139

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  • DOI: https://doi.org/10.1007/BF01852139

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