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Immunochemical Diagnosis of Multiple Myeloma

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Bulletin of Experimental Biology and Medicine Aims and scope

The diagnostic potentialities of complex immunochemical analysis of the serum and daily urine were evaluated in 118 patients with multiple myeloma. In 95 patients, we observed secretion of monoclonal intact immunoglobulins with heavy chains G (N=69), A (N=19), and M (N=4) and biclonal secretion of paraproteins G and A (N=3). Bence-Jones protein was detected in the sera and daily urine of 16 patients and Bence-Jones proteinuria alone was detected in 3 patients. The diagnostic sensitivity of serum immunoelectrophoresis in multiple myeloma is 94.1%. Analysis of paraproteinuria is particularly important in Bence-Jones myeloma, when paraprotein excretion may be not associated with paraproteinemia. Complex study by immunoelectrophoretic and immunoturbidimetric methods in multiple myeloma increases the diagnostic sensitivity to 99.2%.

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Authors and Affiliations

  1. N. N. Blokhin National Research Medical Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia

    N. V. Lyubimova, Yu. S. Timofeev, V. M. Abaev, O. M. Votyakova & N. E. Kushlinskii

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  1. N. V. Lyubimova
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  2. Yu. S. Timofeev
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  3. V. M. Abaev
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  4. O. M. Votyakova
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  5. N. E. Kushlinskii
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Correspondence to N. V. Lyubimova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 1, pp. 99-103, January, 2018

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Lyubimova, N.V., Timofeev, Y.S., Abaev, V.M. et al. Immunochemical Diagnosis of Multiple Myeloma. Bull Exp Biol Med 165, 84–87 (2018). https://doi.org/10.1007/s10517-018-4105-y

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  • DOI: https://doi.org/10.1007/s10517-018-4105-y

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