Zusammenfassung
Bei einem Patienten mit malignem Phäochromocytom führte die Behandlung mit α-methyl-p-Tyrosin zu einer fast vollständigen Normalisierung des Blutdrucks. Propranolol und Phenoxy-benzamin waren vorher ohne großen Erfolg angewendet worden. Das Allgemeinbefinden des Patienten besserte sich beträchtlich. Während der Behandlung fielen die Ausscheidungsraten von Catecholaminen und ihren Metaboliten auf ca. 50% der Werte vor Behandlung ab. Der Nachweis von α-Methyldopa und α-Methylnormetanephrin bewies die Möglichkeit der o-Hydroxylierung von α-methyl-p-Tyrosin. Nach Beendigung der Behandlung stiegen Blutdruckwerte und Ausscheidung von Catecholaminen innerhalb von 2 Tagen wieder in die vor Behandlung gefundenen hochpathologischen Bereiche an.
Summary
In a patient with malignant pheochromocytoma treated unsuccessfully with propranolol and phenoxybenzamine the additional therapy with α-methyl-p-tyrosine resulted in a substantial decrease of the blood pressure to almost normal values. His general condition improved considerably. During therapy the urinary excretion rates of catecholamines and all their metabolites dropped to about 50% of control values. O-Hydroxylation of α-methyl-p-tyrosine could be demonstrated by the isolation of α-methyldopa and α-methylnormetanephrine. After discontinuation of treatment with α-methyl-p-tyrosine blood pressure and catecholamines returned to control values within two days.
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Hengstmann, J.H., Gugler, R. & Dengler, H.J. Malignant pheochromocytoma. Effect of oral α-methyl-p-tyrosine upon catecholamine metabolism. Klin Wochenschr 57, 351–355 (1979). https://doi.org/10.1007/BF01476565
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DOI: https://doi.org/10.1007/BF01476565