Abstract
A total of 22 female patients under age 60 who showed a decrease in bone mineral density (BMD) after menopause and/or bilateral oophorectomy received 600 mg/day ipriflavone (IP) for 1 year, and the effects on bone metabolism and BMD were observed. Although estrogen levels were low in these patients, a significant rise in serum calcitonin and a decrease in serum calcium were observed. Osteocalcin, a bone formation indicator, also showed a significant increase. These findings suggest IP both inhibits bone resorption and promtes bone formation not only in vitro but also in vivo. BMD of cancellous bone was measured using quantitative computed tomography (QCT). Cancellous bone is believed to most sensitively reflect changes in bone metabolism because of its high rate of metabolic turnover [1]. The patients who had not received IP showed a significant decrease in BMD, while those who had received IP showed only a slight decrease. These observations suggest that IP can be used successfully to reduce the rapid decrease in bone density associated with menopause and/or bilateral oophorectomy.
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Ohta, H., Komukai, S., Ikeda, T. et al. The influence of ipriflavone on bone metabolism and reduction of bone mineral density decrease by ipriflavone following menopause or bilateral oophorectomy. J Bone Miner Metab 11 (Suppl 1), S40–S45 (1993). https://doi.org/10.1007/BF02378749
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DOI: https://doi.org/10.1007/BF02378749